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Gastrointestinal stromal tumors (GISTs) are the most commonly observed mesenchymal
tumors of the digestive tract, and they originate from the interstitial cells
of Cajal. GISTs can be divided into KIT/PDGFRA‑mutant GISTs and wild‑type GISTs
based on the...
Cyclin F is a non‑canonical cyclin which is a part of the SKP1‑CUL1‑F‑box
protein (SCF) E3 ubiquitin‑protein ligase complex. Cyclin F is responsible for
target recognition, ubiquitination, and degradation of various molecular targets.
This protein also controls...
Glioblastoma (GBM) is the most common type of primary central nervous system
tumor in adults, which has high mortality and morbidity rates, and short survival
time, namely <15 months after the diagnosis and application of standard therapy,
Endeavors towards identifying key molecular markers for early diagnosis
and treatment are driving the clinical study of papillary thyroid carcinoma (PTC).
Recent studies have indicated that protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D)
Establishing a prognostic genetic signature closely related to the tumor
immune microenvironment (TIME) to predict clinical outcomes is necessary. Using
the Gene Expression Omnibus (GEO) database of a non‑small cell lung cancer (NSCLC)
cohort and the immune...
Gliomas are the most common neoplasm of the human central nervous system.
Glioblastoma multiforme (GBM) is one of the most serious types of gliomas. Although
considerable progress has been made in the development of cancer therapeutic agents,
As one of the most common types of renal cancer, clear cell renal cell carcinoma
(ccRCC) in advanced stages constitutes a continued major challenge for uro‑oncologists,
as the identification of novel driver mutations and the development of novel targeted...
Restoration of normal DNA promoter methylation and expression states of
cancer‑related genes may be an option for the prevention as well as the treatment
of several types of cancer. Constitutional promoter methylation of BRCA1 DNA repair
associated (BRCA1) gene...
Traditionally, musk has been used as an analgesic to treat pain associated
with cancer. Hepatocellular carcinoma (HCC) is an aggressive tumor; however, patients
with liver cancer that received musk were reported to live longer and have a higher
quality of life....
Efficient enrichment and transmembrane transport of cytotoxic reagents are
considered to be effective strategies to increase the efficiency and selectivity
of antitumor drugs targeting solid tumors. In the present study, a recombinant
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