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Boullie, M.C.; Thomine, E.; Demenais, F.; Daveau, M.; Laurent, P.
doi: 10.1159/000249231pmid: 3770256
In a family displaying the familial atypical multiple-mole melanoma syndrome, linkage analyses were performed between HLA and an assumed dominant gene respectively determining each of the following affected phenotypes: (1) precursor lesions; (2) cutaneous malignant melanoma (CMM); and (3) precursor lesions or CMM or both. The results suggest that there is a complex mechanism involving several factors, genetic and environmental interacting with the gene determining precursor lesions to cause the neoplastic transformation.
Torinuki, Wakio; Tagami, Hachiro
doi: 10.1159/000249232pmid: 3770257
An 18-year-old man with solar urticaria is described. The action spectrum ranged from 400 to 500 nm. No inhibition spectrum was found, i.e., the wheal that is induced by visible light was not inhibited by immediate pre- or postirradiation of test sites with light waves longer than 620 nm. The patient developed a wheal at the site of injection of his own serum that had previously been exposed to light in vitro. Though the ordinary passive transfer reaction yielded a positive result, a passive transfer study with the patient’s serum preheated at 56°C for 2 h showed a negative result. These data suggest that he had both circulating photoallergen and reaginic antibodies.
Mooyaart, B.R.; de Jong, G.M.T.; van der Veen, S.; Driessen, L.H.H.M.; Beukeveld, G.J.J.; Grond, J.; Gips, C.H.
doi: 10.1159/000249233pmid: 3770258
A standardized hepatological investigation was performed in 9 unselected patients with erythropoietic protoporphyria (EPP). The aim of this study was to detect early liver involvement due to EPP and to determine the significance of several diagnostic procedures. Scintigraphy revealed slight enlargement of liver and spleen in all cases. Light microscopic examination of liver tissue in 7 patients showed protoporphyrin deposition in 4 and signs of fibrosis in 3 cases. Cirrhosis was not found. Electron microscopical examination (EM) of all 7 cases was negative and needle-shaped crystals were not found. Therefore we regard EM of little diagnostic value in the detection of early liver involvement. The literature on fatal and asymptomatic cases of liver involvement in EPP is discussed with emphasis on possible predictive and provocative factors. A proposal for EPP patients intending to reduce possible risk factors is made.
Imai, Seiji; Burg, Günter; Braun-Falco, Otto
doi: 10.1159/000249234pmid: 3770259
A light microscopic investigation of skin biopsy specimens from 10 patients with plaque stage mycosis fungoides (MF) and from 6 with Sézary’s syndrome (SS) was carried out according to the defined histologic criteria, for the purpose of detecting some morphological characteristics of these diseases for their histological differentiation. This study revealed that some histomorphological differences regarding the epidermal and dermal changes, epidermotropism and the cellular infiltrate existed between MF and SS, and that these diseases were two distinct entities showing differences not only from a clinical and hematologic but also from the histological viewpoint.
doi: 10.1159/000249235pmid: 3770260
A 1% minoxidil lotion was used to treat 670 male patients affected by androgenetic alopecia. Of the 430 patients who completed the 6 months’ treatment, only 78 (18%) had good results. A 1-year follow-up after the drug was suspended showed that the regrowth was present only in 33% of the patients who had had good results, i.e. 6% of the 430.
Misch, K.J.; Dolman, W.F.G.; Neild, V.; Rhodes, E.L.
doi: 10.1159/000249236pmid: 2945742
The antiandrogen cyproterone acetate, which is known to suppress sebum production, but is not a standard therapy, was given in combination with tetracycline to 63 young unmarried men who had failed to respond to 6 months’ tetracycline therapy alone. Fifty-seven patients responded and the mean time to clearance was 5.2 months’ therapy. The main side effects were nodular sub-nipple breast swellings, which occurred in 13 cases (21%). Such side effects were reversible and cleared after 3–4 months following cessation of therapy. Eighty-eight percent of patients relapsed within 3 months of discontinuing therapy.
Neumann, R.; Schmidt, J.B.; Niebauer, G.
doi: 10.1159/000249238pmid: N/A
We present a case of an annular skin lesion in association with a breast cancer. For differential diagnosis we had to consider subacute cutaneous lupus erythematosus and the group of gyrate erythemas. Lupus band test and immune serology were negative. The parallel course of the erythema and the internal malignancy were striking.
Nakagawa, Toshifumi; Nishimoto, Masayoshi; Takaiwa, Takashi
doi: 10.1159/000249239pmid: 3770261
Disseminated epidermolytic acanthoma was observed during PUVA therapy in a patient with Sézary syndrome. The majority of the lesions resolved within 5 months after the cessation of therapy. This circumstantial evidence together with our knowledge of the effects of PUVA suggest that the skin lesions were revealed by topical photochemotherapy.
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