Virchows Archiv

Anzil, A.; Herrlinger, H.; Blinzinger, K.; Kronski, D.

doi: 10.1007/BF00432727pmid: 4141166

Within the framework of an Early Postmortem Brain Sampling Program we had the opportunity to make some light and electron microscopic observations on the orbital cortex of two elderly subjects known to have been free of neurologic and psychiatric disease. Filamentous deposits with the ultrastructural appearance of corpora amylacea were seen inside astrocytic and, more rarely, inside neuronal processes. The findings and their interpretation are discussed in the light of current views on cerebral corpora amylacea and Lafora bodies. It is concluded that today's views on this matter do not account satisfactorily for the present observation or for observations we have quoted from the literature.

Wehner, H.; Bohle, A.

doi: 10.1007/BF00432728pmid: 4217031

The investigations of the kidneys of 80 diabetics, of whom 29 had a nephrotic syndrome, on silver-impregnated semithin sections showed that different morphological changes of the glomerular basement membrane are involved in the nephrotic syndrome. Nine from 29 of the diabetics with nephrotic syndrome in whom punctures were performed owing to renal symptoms showed perimembraneous changes of the basement membrane (in 100% nephrotic syndrome). Apart from the perimembraneous lesions there were homogeneous thickening of the basement membrane (in 48% nephrotic syndrome), splitting of the basement membrane in the sense of a membranoproliferative glomerulonephritis (in 50% nephrotic syndrome) and cases with lightmicroscopically uneventful basement membrane which developed a nephrotic syndrome in 10%.

Wright, Nicholas; Watson, Alexander; Morley, Adrian; Appleton, David; Marks, Janet; Douglas, Adrian

doi: 10.1007/BF00432729pmid: 4280650

A method is described of assessing the proliferative state in the small bowel mucosa employing the metaphase-arresting (stathmokinetic) properties of vincristine, applicable to both animals and man. In the rat a value for the migration rate of 1.78 cell positions per hour was obtained by the stathmokinetic method, in agreement with a further measurement of the migration rate made using tritiated thymidine. Values for the transit time through the crypt (34 hours) and for the cell production rate (39 cells per crypt per hour), are in good agreement with previously published values.

Weber, G.; Fabbrini, P.; Resi, L.

doi: 10.1007/BF00432730pmid: 4217032

In rabbits on a hypercholesterolic diet, the surface of the plaques, at scanning electron microscope examination, looks discontinuous even in specimens obtained with the “critical point” device. Discontinuities of the endothelial lining of the plaques are found also in ultrathin sections by transmission electron microscopy: foam cells do then constitute the superficial row. In proliferative lesions, smooth muscle cells are actively surfacing, reaching sometimes the lumen.

Klöppel, G.; Altenähr, E.; Freytag, G.; Jansen, F.

doi: 10.1007/BF00432731pmid: 4217033

Rabbits were immunized in different ways with bovine insulin in order to study the influence of duration and mode of immunization on the course of experimental immune insulitis and on the induction of diabetes mellitus. 2 groups (II, III) of 10 animals each received four insulin immunizations within four weeks either with predominantly Freund's adjuvant incomplete (FAI) or with exlusively Freund's adjuvant complete (FAC). 3 groups of 10 to 12 animals each were immunized with insulin for a period of 16 weeks. Within this time group IV received four immunizations with predominantly FAI, group V received seven immunization with predominantly FAC, and group VI sixteen immunizations with predominantly FAI.

Schulz, A.; Donath, K.; Delling, G.

doi: 10.1007/BF00432732pmid: 4217034

Osteocytic development was studied in cortical bone of the tibial metaphysis in the rat, with respect to the relationship between age and localization of the cells. The different development stages through which the osteocytes pass during their life cycle are characterized by functional alterations of the osteocyte itself, as well as pericellular structures of bone substance.

Meurs-van Woezik, Hilde; Klein, Hans

doi: 10.1007/BF00432733pmid: 4217035

Internal diameters of the cardiac orifices and of the great vessels were determined in 9 hearts with an atresia of the left atrio-ventricular orifice and/or the aortic ostium and in 7 hearts with an atresia of the right atrio-ventricular orifice and/or pulmonary ostium. Hearts which showed a ventricular septal defect in combination with a patent aortic ostium and left hypoplasia or a pulmonary ostium and right hypoplasia were not included in the material. Twenty-four normal hearts served as a control group. The aorta was measured at 6 sites; the pulmonary trunk, the two pulmonary arteries and the ductus arteriosus were all measured at one site. The age range of the material was from birth to 16 months after birth.

Cozzutto, C.; Felici, N.

doi: 10.1007/BF00432734pmid: 4374799

This paper reviews a case of a newborn child which died soon after birth in consequence of a cytomegalic inclusion disease involving the brain, liver, lungs and kidneys. The interest of the case lies in the unusual finding of lesions of the vascular loops of the renal glomeruli.