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In cardiac cellular electrophysiology the physiological mechanisms underlying the cardiac action potential and its changes during cardiac diseases are major topics of research. Investigation of ionic currents and channels, its coupling to signalling pathways and the cellular homeostasis led to...
Ion channels and transporter proteins are prerequisites for formation and conduction of cardiac electrical impulses. Acting in concert, these proteins maintain cellular Na+ and Ca2+ homeostasis. Since intracellular Ca2+ concentration determines contractile activation, we expect the majority of...
Atrial fibrillation is the most common sustained cardiac arrhythmia. Cellular electrical remodeling includes shortening of action potential duration and effective refractory period that can be explained by concomitant alterations in ion channel activity. While most currents studied are reduced...
Remodeling of both myocytes and interstitial compartments predisposes patients with myocardial hypertrophy and heart failure to an increased risk of sudden cardiac death. In hypertrophied and failing myocardium alterations in the expression and function of various ion channels and transporter...
Unwanted side effects of neuroleptic drugs include enhanced risk of developing cardiac arrhythmias due to prolongation of the QT interval. The electrophysiological basis of these ECG changes is supposed to be blocking of HERG potassium channels which are responsible for the native delayed...
Rotation of the pulse generator around the electrode, also referred to as Twiddler's syndrome, is a rare complication after permanent pacemaker implantation which can lead to partial or total pacing failure. We present a 32 year old heart transplanted man with Twiddler's syndrome three years...
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