Magnetic Resonance in Chemistry

doi: 10.1002/mrc.5284pmid: N/A

No abstract is available for this article.

Krivdin, Leonid B.

doi: 10.1002/mrc.5374pmid: 37344923

Present review is focused on recent experimental and computational advances of the liquid‐phase deuterium nuclear magnetic resonance (NMR). Nowadays, isotropic liquid‐phase 2H NMR became one of the most important instruments for the identification and certification of organic compounds of biological interest together with natural products and biosynthetic molecules. Of special interest are the 2H NMR biochemical and microbiological applications. This review consists of three main parts. The first part deals with the practical applications of 2H NMR to organic compounds of biological interest. The second part is connected with natural products and biosynthetic molecules, while the third part exemplifies and outlines 2H NMR advances in biochemistry and microbiology.

Wei, Siyuan; Ding, Yiming; Song, Kan; Liu, Zao

doi: 10.1002/mrc.5355pmid: 37143296

Artefacts in high‐resolution multidimensional nuclear magnetic resonance (NMR) spectra, known as t1 noise, can significantly downgrade the spectral quality and remain a significant noise source, limiting the sensitivity of most two‐dimensional NMR experiments. In addition to highly sensitive hardware and experimental designs, data post‐processing is a relatively simple and cost‐effective method for suppressing t1 noise. In this study, histograms and quantiles were used to obtain a robust estimation of noise level. We constructed a weighted matrix to suppress the t1 noise. The weighted matrix was calculated from the logistic functions, which were adaptively computed from the spectrum. The proposed method is robust and effective in both simulations and actual experiments. Further, it can maintain the quantitative relationship of the spectrogram and is suitable for various complex peak types.

Zhang, Mao‐Sheng; Jiang, Yu; Cheng, Lei; Yang, Jian‐Wen; Dong, Min‐Jian; Sun, Cheng‐Xin; Xiao, Shi‐Ji

doi: 10.1002/mrc.5370pmid: 37227105

Six lactone derivatives, including four α‐pyrones derivatives (1–4), two α‐furanone derivatives (5 and 6), were isolated from the Dendrobium pendulum. Structural elucidation of these undescribed lactone derivatives were accomplished on the basis of detailed nuclear magnetic resonance analysis, and the absolute configurations of compounds 1–4 were confirmed by electronic circular dichroism (ECD) techniques. The cytotoxic effects of isolated compounds on human breast cancer cell MDA‐MB‐231 were evaluated by the MTT assay.

Trevino, Kimberly M.; Addison, Bennett; Louie, Angelique Y.; Garcia, Joel

doi: 10.1002/mrc.5369pmid: 37254270

Tsakem, Bienvenu; Toussie, Billy Tchegnitegni; Siwe‐Noundou, Xavier; Ponou, Beaudelaire Kemvoufo; Teponno, Rémy Bertrand; Musharraf, Syed Ghulam; Tapondjou, Leon Azefack

doi: 10.1002/mrc.5375pmid: 37340817

From the n‐butanol soluble fraction of the ethanol extract of the medicinal plant Olax subscorpioidea, a previously unreported rotameric biflavonoid glycoside constituted of 4′‐O‐methylgallocatechin‐(4α → 8)‐4′‐O‐methylgallocatechin as aglycone named olasubscorpioside C (1) along with the known 4′‐O‐methylgallocatechin (2) were isolated. Their structures were determined on the basis of spectrometric and spectroscopic techniques including HRFABMS, 1H and 13C NMR, DEPT 135o, HSQC, HMBC, ROESY, and CD followed by comparison with the reported data.