Pharmaceutical Research

Takiguchi, Naomi; Takahashi, Yuki; Nishikawa, Makiya; Matsui, Yuriko; Fukuhara, Yasushi; Oushiki, Daihi; Kiyose, Kazuki; Hanaoka, Kenjiro; Nagano, Tetsuo; Takakura, Yoshinobu

doi: 10.1007/s11095-010-0331-3pmid: 21116691

These findings show a positive correlation between the generation of ROS and the reactivation of silenced transgene expression after hydrodynamic injections.

Negishi, Yoichi; Matsuo, Keiko; Endo-Takahashi, Yoko; Suzuki, Kentaro; Matsuki, Yuuki; Takagi, Norio; Suzuki, Ryo; Maruyama, Kazuo; Aramaki, Yukihiko

doi: 10.1007/s11095-010-0286-4pmid: 20931266

The gene transfer system into skeletal muscle using the combination of BL and US exposure could be an effective means for angiogenic gene therapy in limb ischemia.

Schaffert, David; Kiss, Melinda; Rödl, Wolfgang; Shir, Alexei; Levitzki, Alexander; Ogris, Manfred; Wagner, Ernst

doi: 10.1007/s11095-010-0225-4pmid: 20694527

The optimized LPEI-PEG2 kDa-EGF conjugate displays reduced chemical complexity and efficient poly(I:C)-mediated killing of EGFR overexpressing tumors in vitro and in vivo .

Wauthoz, Nathalie; Deleuze, Philippe; Saumet, Amandine; Duret, Christophe; Kiss, Robert; Amighi, Karim

doi: 10.1007/s11095-010-0329-xpmid: 21116692

Dry temozolomide powder formulations, based on the use of acceptable excipients for inhalation and showing good dispersion properties, represent an attractive alternative for use in local lung cancer therapy.

Koo, Otilia; Rubinstein, Israel; Önyüksel, Hayat

doi: 10.1007/s11095-010-0330-4pmid: 21132352

We propose that CPT-SSM-VIP is a promising targeted nanomedicine and should be further developed as a safe, long-acting, disease-modifying pharmaceutical product for RA.

Kwok, Philip; Tunsirikongkon, Amolnat; Glover, William; Chan, Hak-Kim

doi: 10.1007/s11095-010-0332-2pmid: 21136142

Nano-matrix particles with controlled surface architecture were successfully produced by spray-drying nanosuspensions. Aerosol performance was enhanced with increasing surface roughness due to the reduction in cohesion forces.

Krekels, Elke; Hasselt, Johan; Tibboel, Dick; Danhof, Meindert; Knibbe, Catherijne

doi: 10.1007/s11095-010-0333-1pmid: 21153913

The proposed framework is suitable for the evaluation of paediatric (covariate) models and should be applied to corroborate the descriptive and predictive properties of these models.

Deng, Jingjing; Wen, Yuting; Wang, Cuifeng; Pan, Shirong; Gu, Huaiyu; Zeng, Xin; Han, Lina; Zhao, Yuefang; Feng, Min; Wu, Chuanbin

doi: 10.1007/s11095-010-0335-zpmid: 21161337

This formulation provided a versatile approach for preparing high efficiency of the polycation-based gene vectors. It also reinforced the finding of earlier studies that nuclear import and endosomal escape were rate-limiting steps for nonviral gene delivery.

Kanwar, Shailender; Yu, Yingjie; Nautiyal, Jyoti; Patel, Bhaumik; Padhye, Subhash; Sarkar, Fazlul; Majumdar, Adhip

doi: 10.1007/s11095-010-0336-ypmid: 21161336

Our results suggest that CDF together with the conventional chemotherapeutics could be an effective treatment strategy for preventing the emergence of chemo-resistant colon cancer cells by eliminating CSCs.

Ishii, Hiroshi; Suzuki, Tsukasa; Todo, Hiroaki; Kamimura, Mitsuhiro; Sugibayashi, Kenji

doi: 10.1007/s11095-010-0337-xpmid: 21181550

The present results suggest the usefulness of topical application of the ionic steroidal prodrugs onto throat skin followed by iontophoresis treatment for directly delivering the steroid to the trachea.