Pharmaceutical Research

Pardridge, William; Boado, Ruben

doi: 10.1007/s11095-009-9939-6pmid: 19609743

A no-observable-adverse-effect level is established in the Rhesus monkey for the acute administration of the HIRMAb-GDNF fusion protein. The fusion protein targeting the insulin receptor has a PK profile similar to a classical small molecule.

Favretto, Marco; Marouf, Showan; Ioannou, Panagiotis; Antimisiaris, Sophia; Parker, Terence; Kallinteri, Paraskevi

doi: 10.1007/s11095-009-9940-0pmid: 19626426

Arsonoliposomes showed “selective” toxicity towards medulloblastoma cells inducing apoptosis after 2 hs of incubation. Therefore, arsonoliposomes are promising anticancer vehicles for brain tumour treatment.

Hartman, Izabela; Gillies, Alison; Arora, Sonia; Andaya, Christina; Royapet, Nitya; Welsh, William; Wood, David; Zauhar, Randy

doi: 10.1007/s11095-009-9941-zpmid: 19626425

This work demonstrates an effective combination of computational analysis and simple bacterial screens for rapid identification of potential hormone-like therapeutics.

Bender, Gregor; Gosset, James; Florian, Jeff; Tan, Keith; Field, Mark; Marshall, Scott; DeJongh, Joost; Bies, Robert; Danhof, Meindert

doi: 10.1007/s11095-009-9942-ypmid: 19669867

Analysis of simulations indicated that three post-PD samples had the best cost/benefit ratio by providing a significant increase in the precision (and minor improvement in bias) of both PK and PD parameters compared with no PK sampling.

Ishihara, Tsutomu; Takeda, Miho; Sakamoto, Haruka; Kimoto, Ayumi; Kobayashi, Chisa; Takasaki, Naoko; Yuki, Kanae; Tanaka, Ken-ichiro; Takenaga, Mitsuko; Igarashi, Rie; Maeda, Taishi; Yamakawa, Naoki; Okamoto, Yoshinari; Otsuka, Masami; Ishida, Tatsuhiro;

Choi, Sunga; Kim, Tae Woong; Singh, Shivendra

doi: 10.1007/s11095-009-9944-9pmid: 19629651

Rh2-mediated cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1 -dependent inhibition of kinase activities of G 1 -S specific Cdks/cyclin complexes.

Arifin, Davis; Lee, Kam; Wang, Chi-Hwa; Smith, Kenneth

doi: 10.1007/s11095-009-9945-8pmid: 19639394

Carmustine penetration from Gliadel® wafers implanted in brain is limited by rapid elimination via transcapillary exchange. Therefore, it could be useful to consider other therapeutic agents such as paclitaxel . In addition, local convective flow within the cavity appears to be a crucial factor in distributing the drug so that the tumor domain near the ventricle is prone to minimal drug exposure. Thus, complete removal of the tumor from this region is of particular concern.

Yao, Jia; Dokuru, Dushyanth; Noestheden, Matthew; Park, SungAe; Kerwin, Bruce; Jona, Janan; Ostovic, Drazen; Reid, Darren

doi: 10.1007/s11095-009-9946-7pmid: 19669100

Polysorbate 80 autoxidation follows the classical rate law and is largely dependent on the unsaturated fatty acid ester substituents. Clarification of the substituents’ roles will aid formulators in the selection of appropriate polysorbates to minimize oxidative liabilities.

Hwang, Tsong-Long; Fang, Chia-Lang; Chen, Chao-Huang; Fang, Jia-You

doi: 10.1007/s11095-009-9947-6pmid: 19653070

The nanoemulsions are feasible to load cisplatin for intravesical drug delivery.

Keum, Young-Sam; Oo Khor, Tin; Lin, Wen; Shen, Guoxiang; Han Kwon, Ki; Barve, Avantika; Li, Wenge; Kong, Ah-Ng

doi: 10.1007/s11095-009-9948-5pmid: 19669099

Our findings indicate that broccoli sprouts can serve as a good dietary source of SFN in vivo and that they have significant inhibitory effects on prostate tumorigenesis.