Pharmaceutical Research

doi: 10.1007/s11095-008-9715-zpmid: N/A

Macleod, Neil; Matousek, Pavel

doi: 10.1007/s11095-008-9587-2pmid: 18415048

This article reviews emerging Raman techniques (Spatially Offset and Transmission Raman Spectroscopy) for non-invasive, sub-surface probing in process control and forensic applications. New capabilities offered by these methods are discussed and several application examples are given including the non-invasive detection of counterfeit drugs through blister packs and opaque plastic bottles and the rapid quantitative analysis of the bulk content of pharmaceutical tablets and capsules without sub-sampling.

Hein, Christopher; Liu, Xin-Ming; Wang, Dong

doi: 10.1007/s11095-008-9616-1pmid: 18509602

Click chemistry refers to a group of reactions that are fast, simple to use, easy to purify, versatile, regiospecific, and give high product yields. While there are a number of reactions that fulfill the criteria, the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes has emerged as the frontrunner. It has found applications in a wide variety of research areas, including materials sciences, polymer chemistry, and pharmaceutical sciences. In this manuscript, important aspects of the Huisgen cycloaddition will be reviewed, along with some of its many pharmaceutical applications. Bioconjugation, nanoparticle surface modification, and pharmaceutical-related polymer chemistry will all be covered. Limitations of the reaction will also be discussed.

Shaik, Imam; George, Jancy; Thekkumkara, Thomas; Mehvar, Reza

doi: 10.1007/s11095-008-9601-8pmid: 18626753

DAS protects the liver from warm IR injury by reducing oxidative stress through, at least in part, induction of heme oxygenase-1 and inhibition of CYP2E1.

Sakae, Rie; Ishikawa, Atsuko; Niso, Tomoko; Komori, Yukiko; Aiba, Tetsuya; Kawasaki, Hiromu; Kurosaki, Yuji

doi: 10.1007/s11095-008-9612-5pmid: 18581208

ARF decreases the lithium disposition to CSF, possibly by promoting lithium efflux from CSF due to increased NKCC1 expression in the choroid plexus.

Raula, Janne; Thielmann, Frank; Kansikas, Jarno; Hietala, Sami; Annala, Minna; Seppälä, Jukka; Lähde, Anna; Kauppinen, Esko

doi: 10.1007/s11095-008-9613-4pmid: 18584311

In order to preserve good flowability together with good physical stability, the best coating would contain two l -leucine layers, the inner layer being formed by diffusion (physical stability) and the outer layer by vapour deposition (flowability).

Chattopadhyay, Niladri; Zastre, Jason; Wong, Ho-Lun; Wu, Xiao; Bendayan, Reina

doi: 10.1007/s11095-008-9615-2pmid: 18516666

These data suggest that SLNs could be a promising drug delivery system to enhance brain uptake of atazanavir and potentially other PIs.

Zheng, Hong; Hu, Wei; Yu, Dongfang; Shen, De-Yu; Fu, Siqing; Kavanagh, John; Wei, I-Chien; Yang, David

doi: 10.1007/s11095-008-9621-4pmid: 18509599

Low-dose DDAP enhances drug delivery to platinum-resistant ovarian cancer cells and substantially inhibits their growth by inducting apoptosis and arresting cells in the S-phase, suggesting that DDAP may overcome platinum resistance in ovarian cancer.

Murnane, Darragh; Martin, Gary; Marriott, Christopher

doi: 10.1007/s11095-008-9622-3pmid: 18509598

The size of the aggregates in the HFA suspensions was found to correlate directly with the FPFs determined by impaction.

Xie, Yong; Cao, Wenjin; Krishnan, Sampathkumar; Lin, Hong; Cauchon, Nina

doi: 10.1007/s11095-008-9624-1pmid: 18523875

An MCR-Raman method has been developed for the quantitative determination of five different mannitol polymorphic forms in the presence of sucrose and protein.