Pharmaceutical Research

Guzy, Serge; Hunt, Anthony

doi: 10.1023/A:1012191831815pmid: 9358539

Purpose. Single dose pharmacokinetic data from several individuals can be used to predict the fraction of the population that is expected to be within a therapeutic range. Without having some measure of its reliability, however, that prediction is only likely to marginally influence critical drug development decision making. The system (Forecaster) described generates an approximate prediction interval that contains the original prediction and where, for example, the probability is approximately 85% that a similar prediction from a new set of data will also be within the range. The goal is to validate that the system functions as designed.

Gaither, Caroline; Bagozzi, Richard; Ascione, Frank; Kirking, Duane

doi: 10.1023/A:1012143915886pmid: 9358540

Purpose. To improve upon the theory of reasoned action and apply it to pharmaceutical research, we investigated the effects of relevant appraisals, attributes, and past behavior of physicians on the use of drug information sources. We also examined the moderating effects of practice characteristics.

Lian, Tianshun; Ho, Rodney

doi: 10.1023/A:1012195932724pmid: 9358541

Purpose. To determine whether the non-toxic pentameric B subunit of Cholera toxin (CTB) binding to ganglioside GM1 on both the lipid vesicles and epithelial cells may provide a means to target lipid vesicles to mucosal cells expressing surface GM1.

Schaner, Marci; Wang, Juan; Zevin, Shoshana; Gerstin, Karin; Giacomini, Kathleen

doi: 10.1023/A:1012148016794pmid: 9358542

Purpose. The goal of this study was to develop a mammalian expression system for the cloned rat intestinal, Na+-dependent, purine-selective nucleoside transporter (SPNTint) and to study the interactions of nucleosides and nucleoside analogs with this transporter.

Turner, Norris; Ferry, Laura; Price, Matthew; Cullander, Christopher; Guy, Richard

doi: 10.1023/A:1012100100865pmid: 9358543

Purpose. (1) To determine the extent of iontophoretic transport as a function of molecular weight (MW) of the penetrant; and (2) to visually and quantitatively characterize the iontophoretic transport pathways (follicular (F) versus nonfollicular (NF)) of the fluorescently-labeled poly-L-lysines employed.

Knipp, Gregory; Vander Velde, David; Siahaan, Teruna; Borchardt, Ronald

doi: 10.1023/A:1012152117703pmid: 9358544

Purpose. To investigate the relationships between the β-turn structure of a peptide and its passive diffusion across Caco-2 cell monolayers, an in vitro model of the intestinal mucosa.

Sorensen, Mette; Steenberg, Betina; Knipp, Gregory; Wang, Wen; Steffansen, Bente; Frokjaer, Sven; Borchardt, Ronald

doi: 10.1023/A:1012104301773pmid: 9358545

Purpose. To investigate the effects of the β-turn structure of a peptide on its permeation via the paracellular and transcellular routes across cultured bovine brain microvessel endothelial cell (BBMEC) monolayers, an in vitro model of the blood-brain barrier (BBB).

Patel, Hitesh; Tokarski, John; Hopfinger, A.

doi: 10.1023/A:1012156318612pmid: 9358546

Purpose. The purpose of this study was to identify the key physicochemical molecular properties of polymeric materials responsible for gaseous diffusion in the polymers.

Elkoshi, Zeev

doi: 10.1023/A:1012108402682pmid: 9358547

Purpose. To investigate dissolution data variability and its origins.

Marston, S.; Polli, James

doi: 10.1023/A:1012160419520pmid: 9358548

Purpose. The intent was to investigate three direct curve comparison metrics, the Rescigno Index,f1, and the Chinchilli Metric as tools to assess relative bioavailablity (BA) and bioequivalence (BE). The specific objectives were to 1) estimate relative bioavailability and bioequivalence and 2) compare detection of profile shape differences with typical (i.e. AUC and Cmax) criteria.