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doi: 10.1111/j.1365-2125.1974.tb00267.xpmid: N/A
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LEE, G.; LINGSCH, C.; LYLE, P.T.; MARTIN, K.
doi: 10.1111/j.1365-2125.1974.tb00270.xpmid: 22454911
1 The influx of [14C] ‐choline and the efflux of 22Na in human erythrocytes were measured in vitro using blood from patients treated with lithium, patients not on lithium and healthy individuals. 2 The administration of lithium to patients significantly reduces the transport of choline; during the first 6 weeks of treatment the influx of choline is about half the normal rate, later it falls to around 10%. 3 This inhibition of choline transport is not dependent on the presence of lithium in the incubation medium. 4 The active and passive efflux of sodium are apparently not affected by lithium treatment.
HELLEBERG, L.; RUBIN, A.; WOLEN, R.L.; RODDA, B.E.; RIDOLFO, A.S.; GRUBER, CM.
doi: 10.1111/j.1365-2125.1974.tb00271.xpmid: 22454912
1 The effect of repeated administration of phenobarbitone on the plasma disposition of fenoprofen (±‐2‐(3‐phenoxyphenyl) propionic acid) was investigated in rats and man. 2 The plasma elimination rate constants increased significantly and the rats excreted proportionately more metabolized fenoprofen in the urine. These findings are consistent with an increase in the rate of metabolism of fenoprofen. 3 This interaction between phenobarbitone (and presumably other inducers of drug metabolizing enzymes) and fenoprofen should be considered when evaluating the clinical usefulness of fenoprofen.
CHAPUT, D.M.; SAINTONGE, DE; ROBERTS, C.J.C.; STRICKLAND, I.D.; VERE, D.W.
doi: 10.1111/j.1365-2125.1974.tb00272.xpmid: 22454913
1 Fifteen patients with diastolic blood pressures between 90 and 120 mmHg were admitted to a trial comparing placebo with practolol at doses up to 500 mg 12 hourly. 2 The trial was a double blind cross over study. Treatments were allocated at random and each treatment block lasted 12 weeks. 3 Ten patients completed the trial, and none of those who withdrew experienced serious unwanted effects. 4 Practolol caused significant falls in standing systolic and diastolic pressures and the supine diastolic pressure.
doi: 10.1111/j.1365-2125.1974.tb00273.xpmid: 22454914
1 Four equal‐sexed groups of eight normal subjects were given single doses of either (±)‐propranolol (120 mg), (+)‐propranolol (120 mg), diazepam (6 mg) or placebo using double‐blind procedure and their effects studied under three types of experimental stress and at rest. 2 Finger tremor, EEG, averaged auditory evoked response, skin conductance, heart rate and respiratory rate were measured at each time of testing, and subjects also completed performance tests (reaction time, tapping speed and symbol copying) and subjective mood scales. 3 Neither (+)‐ nor (±)‐propranolol had any beneficial effects on mood and physiological tests showed that, although adequate β‐adrenoceptor blockade was achieved, there was no evidence of sedation. 4 Diazepam reduced subjective anxiety, significantly lessened the main amplitude of the auditory evoked response and also reduced the proportion of slower rhythms in the EEG. 5 The results suggest that (+)‐ and (±)‐propranolol have no psychotropic effects on induced anxiety and that their modes of action are fundamentally different from that of diazepam.
doi: 10.1111/j.1365-2125.1974.tb00274.xpmid: 22454915
1 Twelve chronically anxious psychiatric out‐patients, comprising six with somatic anxiety and six with psychic anxiety, were treated with (±)‐propranolol, diazepam and placebo for one week each in flexible dosage using a balanced cross‐over experimental design. 2 After each treatment, in addition to ratings completed by patient and psychiatrist, finger tremor, EEG, averaged auditory evoked response, skin conductance, heart and respiratory rate were measured. 3 Diazepam significantly increased the amount of fast activity (13.5–26 Hz) in the EEG but produced few peripheral effects apart from a reduction in finger tremor. 4 Propranolol had no central physiological effects but reduced both pulse rate and finger tremor. 5 The physiological effects of propranolol in chronic anxiety are different from those of diazepam and therapeutic benefit appears to be due to a direct effect on certain somatic symptoms.
EVANS, MARION E.; SHENFIELD, GILLIAN M.; PATERSON, J.W.
doi: 10.1111/j.1365-2125.1974.tb00275.xpmid: 22454916
1 The absorption, excretion and metabolism of [3H]‐salmefamol, a new sympathomimetic bronchodilator drug, have been studied in asthmatic patients. 2 Following oral administration of 1 or 2 mg to four patients the drug was well absorbed, peak plasma levels occurring from 0.6‐2.0 h after administration. An improvement in forced expiratory volume in 1 s (FEV1) (ranging from 12–50% above baseline) was seen. 3 Following aerosol administration of 0.22‐0.34 mg to four patients a rapid rise in FEV1 was seen (range 26–117%). The plasma and urinary pictures following this route were similar to those seen after oral administration, suggesting that the majority of the dose was swallowed. 4 Very little free salmefamol was found in plasma or urine, the majority being present as metabolites. Urinary radioactivity was mainly present in the form of sulphate conjugates of at least two compounds, one of which was salmefamol. The other compound has not been identified but it is suggested that it may be an active metabolite.
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