Archives of Virology

Boyd, Janice E.; Sommerville, R. G.

doi: 10.1007/bf01249687pmid: 4370660

SummaryA large group of related benzo(b)thiophene derivatives was screened for antiviral activity in a simple cell culture system. Three viruses were used; influenza A2, vaccinia and herpes simplex type 1.51 per cent of the compounds inhibited at least one virus by ≥75 per cent, while 25 per cent were inhibitory by ≥90 per cent. This high degree of antiviral activity is in agreement with the range of biological properties possessed by benzo(b)thiophene derivatives as a whole.

Boyd, Janice E.; Sommerville, R. G.

doi: 10.1007/bf01249688pmid: 4371473

SummaryA rapid, simple method for the screening of large numbers of compounds for antiviral activity is described. The appropriate virus is grown in cell culture for one growth-cycle in the presence of test compound dilutions and viral growth is assessed by an indirect fluorescent antibody technique. Compound toxicity can be predetermined microscopically or by a quantitative method.