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Current Genetics Volume 64 Issue 6

Subject Areas: Genetics
Publisher: Springer Berlin Heidelberg - Springer Journals
ISSN: 0172-8083
SJR: 85

LitStream

Journal Article

Genetic background effects in quantitative genetics: gene-by-system interactions

Sardi, Maria; Gasch, Audrey

2018 Current Genetics

doi:10.1007/s00294-018-0835-7 pmid:29644456

Proper cell function depends on networks of proteins that interact physically and functionally to carry out physiological processes. Thus, it seems logical that the impact of sequence variation in one protein could be significantly influenced by genetic variants at other loci in a genome....
Open Access

Journal Article

How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis

Tomita, Kazunori

2018 Current Genetics

doi:10.1007/s00294-018-0836-6 pmid:29663033

Telomerase, the enzyme that replenishes telomeres, is essential for most eukaryotes to maintain their generations. Telomere length homeostasis is achieved via a balance between telomere lengthening by telomerase, and erosion over successive cell divisions. Impaired telomerase regulation leads to...
Open Access

Journal Article

Seq-ing answers: uncovering the unexpected in global gene regulation

Otto, George; Brar, Gloria

2018 Current Genetics

doi:10.1007/s00294-018-0839-3 pmid:29675618

The development of techniques for measuring gene expression globally has greatly expanded our understanding of gene regulatory mechanisms in depth and scale. We can now quantify every intermediate and transition in the canonical pathway of gene expression—from DNA to mRNA to protein—genome-wide....
LitStream

Journal Article

Specialised DNA polymerases in Escherichia coli: roles within multiple pathways

Henrikus, Sarah; Oijen, Antoine; Robinson, Andrew

2018 Current Genetics

doi:10.1007/s00294-018-0840-x pmid:29700578

In many bacterial species, DNA damage triggers the SOS response; a pathway that regulates the production of DNA repair and damage tolerance proteins, including error-prone DNA polymerases. These specialised polymerases are capable of bypassing lesions in the template DNA, a process known as...
LitStream

Journal Article

Regulation of kinetochore configuration during mitosis

Dhatchinamoorthy, Karthik; Mattingly, Mark; Gerton, Jennifer

2018 Current Genetics

doi:10.1007/s00294-018-0841-9 pmid:29704052

Successful proliferation and function of an organism relies on the equal segregation of its genetic material during cell division. Duplicate sister chromatids need to accurately segregate at mitosis. Precise segregation depends on a multicomplex protein structure called the kinetochore. The...
LitStream

Journal Article

HMGB proteins involved in TOR signaling as general regulators of cell growth by controlling ribosome biogenesis

Vizoso-Vázquez, A.; Barreiro-Alonso, A.; González-Siso, M.; Rodríguez-Belmonte, E.; Lamas-Maceiras, M.; Cerdán, M.

2018 Current Genetics

doi:10.1007/s00294-018-0842-8 pmid:29713761

The number of ribosomes and their activity need to be highly regulated because their function is crucial for the cell. Ribosome biogenesis is necessary for cell growth and proliferation in accordance with nutrient availability and other external and intracellular signals. High-mobility group B...
LitStream

Journal Article

Critical roles of Shugoshin and histones as tension sensors during mitosis

Buehl, Christopher; Kuo, Min-Hao

2018 Current Genetics

doi:10.1007/s00294-018-0846-4 pmid:29796904

Biorientation of paired sister chromosomes is required to maintain mitotic fidelity. A critical signal indicative of bipolar attachment is tension between cohesion-linked sister chromatids. Key components of the tension signaling apparatus include the Shugoshin family of proteins and the tension...
LitStream

Journal Article

Mechanisms for the epigenetic inheritance of stress response in single cells

Xue, Yuan; Acar, Murat

2018 Current Genetics

doi:10.1007/s00294-018-0849-1 pmid:29846762

Cells have evolved to dynamically respond to different types of environmental and physiological stress conditions. The information about a previous stress stimulus experience by a mother cell can be passed to its descendants, allowing them to better adapt to and survive in new environments. In...
LitStream

Journal Article

Scarless genome editing: progress towards understanding genotype–phenotype relationships

Elison, Gregory; Acar, Murat

2018 Current Genetics

doi:10.1007/s00294-018-0850-8 pmid:29872908

The ability to predict phenotype from genotype has been an elusive goal for the biological sciences for several decades. Progress decoding genotype–phenotype relationships has been hampered by the challenge of introducing precise genetic changes to specific genomic locations. Here we provide a...
LitStream

Journal Article

Hyphal development in Candida albicans from different cell states

Su, Chang; Yu, Jing; Lu, Yang

2018 Current Genetics

doi:10.1007/s00294-018-0845-5 pmid:29796903

Candida albicans is an important opportunistic fungal pathogen of immunocompromised individuals. The ability to switch between yeast, pseudohyphal, and hyphal growth forms (polymorphism) is one of the most investigated virulence attributes of C. albicans. The usual method for inducing hypha...

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