SLEEP

Carvalhas-Almeida, Catarina; Sehgal, Amita

doi: 10.1093/sleep/zsae314pmid: 39812780

Glia are increasingly appreciated as serving an important function in the control of sleep and circadian rhythms. Glial cells in Drosophila and mammals regulate daily rhythms of locomotor activity and sleep as well as homeostatic rebound following sleep deprivation. In addition, they contribute to proposed functions of sleep, with different functions mapping to varied glial subtypes. Here, we discuss recent findings in Drosophila and rodent models establishing a role of glia in circadian or sleep regulation of synaptic plasticity, brain metabolism, removal of cellular debris, and immune challenges. These findings underscore the relevance of glia for benefits attributed to sleep and have implications for understanding the neurobiological mechanisms underlying sleep and associated disorders.

Stee, Whitney; Legouhy, Antoine; Guerreri, Michele; Foti, Michael-Christopher; Lina, Jean-Marc; Zhang, Hui; Peigneux, Philippe

doi: 10.1093/sleep/zsaf006pmid: 39798081

Enhancing the retention of recent memory traces through sleep reactivation is possible via Targeted memory reactivation (TMR), involving cueing learned material during posttraining sleep. Evidence indicates detectable short-term microstructural changes in the brain within an hour after motor sequence learning, and posttraining sleep is believed to contribute to the consolidation of these motor memories, potentially leading to enduring microstructural changes. In this study, we explored how TMR during posttraining sleep affects performance gains and delayed microstructural remodeling, using both standard diffusion tensor imaging and advanced neurite orientation dispersion and density imaging. Sixty healthy young adults participated in a 5 days protocol, undergoing five diffusion-weighted imaging sessions, pre- and post-two motor sequence training sessions, and after a posttraining night of either regular sleep (RS) or TMR. Results demonstrated rapid skill acquisition on day 1, followed by performance stabilization on day 2, and improvement on day 5, in both RS and TMR groups. (Re)training induced widespread microstructural changes in motor-related areas, initially involving the hippocampus, followed by a delayed engagement of the caudate nucleus. Mean Diffusivity changes were accompanied by increased neurite density index in the putamen, suggesting increased neurite density, while free water fraction reduction indicated glial reorganization. TMR-related structural differences emerged in the dorsolateral prefrontal cortex on day 2 and the right cuneus on day 5, suggesting unique sleep TMR-related neural reorganization patterns. Persistence of practice-related structural changes, although moderated over time, suggests a lasting neural network reorganization, partially mediated by sleep TMR.

Lin, Yu-Hsiang; Lin, Kuo-Jen; Chen, Jau-Yuan

doi: 10.1093/sleep/zsaf002pmid: 39801372

Aton, Sara J

doi: 10.1093/sleep/zsae316pmid: 39749971

Zhang, Zhongxing; Khatami, Ramin

doi: 10.1093/sleep/zsae304pmid: 39792617

Youngstedt, Shawn D; Soares Passos, Giselle; Falck, Ryan S; Gonçalves Santana, Marcos

doi: 10.1093/sleep/zsaf016pmid: 39841157

Pickup, Emily; Weber, Franz

doi: 10.1093/sleep/zsae312pmid: 39756401

Lanza, Giuseppe; Mogavero, Maria P; Ferri, Raffaele

doi: 10.1093/sleep/zsae311pmid: 39742414

Boardman, Johanna M; Lim, Jeryl Y L

doi: 10.1093/sleep/zsaf008pmid: 39806766

Burgess, Helen J; Rodgers, Allie A; Rizvydeen, Muneer; Mongefranco, Gabriel; Fayyaz, Zainab; Fejer, Agnes; Johnson, Ashlyn; Goldstein, Cathy A

doi: 10.1093/sleep/zsae290pmid: 39813160