Clinical Science

Pigeyre, Marie; Yazdi, Fereshteh T.; Kaur, Yuvreet; Meyre, David

2016 Clinical Science

doi: 10.1042/CS20160136pmid: 27154742

Recent advancements in research methodology have partially decoded the genetic, epigenetic and metagenomic basis of obesity, and have improved our understanding of this highly prevalent disease. This paper highlights the current knowledge in this field, and provides suggestions for translational personalized medicine applications.

Batchu, Sri N.; Brijmohan, Angela S.; Advani, Andrew

2016 Clinical Science

doi: 10.1042/CS20160084pmid: 27154743

Despite its name, histone deacetylase 6 (HDAC6) resides primarily in the cytosol and exerts both enzymatic and non-enzymatic effects on cellular function. HDAC6 inhibitors are being investigated for their effects in cancer, neurodegenerative diseases, cardiovascular disease, inflammation and kidney disease.

Zimmerman, Margaret A.; Budish, Rebecca A.; Kashyap, Shreya; Lindsey, Sarah H.

2016 Clinical Science

doi: 10.1042/CS20160114pmid: 27154744

The recent discovery of the G protein-coupled oestrogen receptor (GPER) presents new challenges and opportunities for understanding the physiology, pathophysiology and pharmacology of many diseases. This review will focus on the expression and function of GPER in hypertension, kidney disease, atherosclerosis, vascular remodelling, heart failure, reproduction, metabolic disorders, cancer, environmental health and menopause. Furthermore, this review will highlight the potential of GPER as a therapeutic target.

Faure, Cécile; Charlot, Keyne; Henri, Stéphane; Hardy-Dessources, Marie-dominique; Hue, Olivier; Antoine-Jonville, Sophie

2016 Clinical Science

doi: 10.1042/CS20150461pmid: 26980346

The aim of this project was to determine if environmental temperature alters glucose regulation. Our main finding is that a meal or a glucose load elicits exaggerated increase in blood glucose when the environmental temperature is warm.

Burillo, Elena; Tarin, Carlos; Torres-Fonseca, Monica-Maria; Fernandez-García, Carlos-Ernesto; Martinez-Pinna, Roxana; Martinez-Lopez, Diego; Llamas-Granda, Patricia; Camafeita, Emilio; Lopez, Juan Antonio; Vega de Ceniga, Melina; Aviram, Michael; Egido, Jesus; Blanco-Colio, Luis-Miguel; Martín-Ventura, Jose-Luis

2016 Clinical Science

doi: 10.1042/CS20160185pmid: 26993251

Decreased paraoxonase-1 (PON1) activity is associated with human and experimental abdominal aortic aneurysm (AAA). Overexpression of PON1 protected mice from AAA development induced by elastase, decreasing oxidative stress, apoptosis and inflammation. PON1 may provide a novel therapeutic target for AAA prevention.