Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

DeepDyve requires Javascript to function. Please enable Javascript on your browser to continue.

Pharmaceutical Chemistry Journal Volume 47 Issue 12

Subject Areas: Drug Discovery
Publisher: Springer US - Springer Journals
ISSN: 0091-150X
SJR: 34

LitStream

Journal Article

Problems and Prospects of Gene Therapy Against HIV

Schneider, A.; Wagner, A.; Davydova, E.; Smirnov, A.; Glazkov, I.; Shegai, M.; Glazkova, D.

2014 Pharmaceutical Chemistry Journal

doi:10.1007/s11094-014-1023-9

Possibilities for the application of gene therapy based on insertion of transgenes into a patient’s cells in order to express anti-HIV agents interfering with the virus life cycle analogously to highly active antiretroviral therapy (HAART) were reviewed. Anti-HIV agents based on various types of...
LitStream

Journal Article

Synthesis and Antiviral Activity of Ethyl 1,2-dimethyl-5-Hydroxy-1H-Indole-3-carboxylates and Their Derivatives

Ivashchenko, A.; Yamanushkin, P.; Mit’kin, O.; Kisil’, V.; Korzinov, O.; Vedenskii, V.; Leneva, I.; Bulanova, E.; Bychko, V.; Okun’, I.

2014 Pharmaceutical Chemistry Journal

doi:10.1007/s11094-014-1024-8

New substituted ethyl 5-hydroxy-1,2-dimethyl-1H-indole-3-carboxylates and 7,8-dimethyl-1,2,3,7-tetrahydro[1,3]oxazino[5,6-e]indole-9-carboxylates including arbidol analogs in addition to 6-hydroxy-1-methyl-7-pyridin-3-yl-4,5-dihydropyrrolo[4,3,2-de]isoquinolin-3(1H)-ones and...
LitStream

Journal Article

Synthesis and Antineoplastic Properties of 3-Substituted 5,5-Dimethylbenzo[h]Quinazolin-4(3H)-Ones

Markosyan, A.; Torshirzad, N.; Shakhbazyan, G.; Arsenyan, F.

2014 Pharmaceutical Chemistry Journal

doi:10.1007/s11094-014-1025-7

Ethyl 2-cyano-3,3-dimethyl-4-phenylbutanoate was cyclized into 1-amino-3,3-dimethyl-3,4-dihydronaphthalene-2-ethylcarboxylate, condensation of which with isothiocyanates synthesized 3-substituted 5,5-dimethyl-2-thioxo-2,3,5,6-tetrahydrobenzo[h]quinazolin-4(1H)-ones. The antineoplastic properties...
LitStream

Journal Article

Synthesis and Neurotropic Activity of 8-Amino Derivatives of Condensed Thieno[3,2-d]- and Furo[3,2-d]Pyrimidines

Sirakanyan, S.; Ovakimyan, A.; Noravyan, A.; Minasyan, N.; Dzhagatspanyan, I.; Nazaryan, I.; Akopyan, A.

2014 Pharmaceutical Chemistry Journal

doi:10.1007/s11094-014-1026-6

New derivatives of pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines based on 3-chloro derivatives of pyrano[3,4-c]pyridines and pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]furo[3,2-d]pyrimidines based on previously prepared 8-chloro derivatives were synthesized. Studies of the biological...
LitStream

Journal Article

Prediction of the Octanol–Water Partition Coefficients of N-Aryl-Substituted Anthranilic Acid Derivatives

Andryukov, K.; Korkodinova, L.

2014 Pharmaceutical Chemistry Journal

doi:10.1007/s11094-014-1027-5

The dependence of lipophilicity constants (log P) on quantum-chemical parameters of structural fragments in N-aryl-substituted anthranilic acid derivatives was studied. Quantum-chemical calculations of the structures of the studied compounds were performed using the Gaussian 03 program. Three...
LitStream

Journal Article

Development and Validation of a Method for Quantitative Determination of Kemantane Drug Substance by Gas Chromatography

Tolkacheva, A.; Grushevskaya, L.; Avdyunina, N.; Pyatin, B.; Prokof’eva, V.; Gaevaya, L.

2014 Pharmaceutical Chemistry Journal

doi:10.1007/s11094-014-1028-4

A new technique for quantitative determination of the active ingredient in pharmaceutical drug substance kemantane (5-hydroxyadamantan-2-one) using gas chromatography with a flame-ionization detector (GC-FID) was developed and validated. The solution. Bromophenol blue was performed on a WCOT...
LitStream

Journal Article

Voltammetric Determination of Acetylcysteine in Drugs Using an Electrode Modified by an Osmium Hexacyanocobaltate Film

Shaidarova, L.; Gedmina, A.; Zhaldak, E.; Chelnokova, I.; Budnikov, G.

2014 Pharmaceutical Chemistry Journal

doi:10.1007/s11094-014-1029-3

It was established that an inorganic film of osmium(III) hexacyanocobaltate(II) (OHCC) deposited on the surface of a glassy carbon (GC) electrode exhibited catalytic activity for electro-oxidation of acetylcysteine (AC). The catalytic effect was manifested by a greater than 300 mV decrease in the...
LitStream

Journal Article

Standardization of Humic Acids of Lowland Wood-Grass Peat from Tomsk Region

Zykova, M.; Belousov, M.; Gur’ev, A.; Akhmedzhanov, R.; Yusubov, M.

2014 Pharmaceutical Chemistry Journal

doi:10.1007/s11094-014-1030-x

Diagnostic properties of humic acids of lowland wood-grass peat from Klyukvennoe deposit (Tomsk Region) were studied. Criteria for the identification and quality estimation of humic acids obtained from this source were established. The results showed the expediency of using these criteria as the...

results per page

Prev
1
Next