Quantitative Assessment of Rectal Cancer Response to Neoadjuvant Combined Chemotherapy and Radiation Therapy: Comparison of Three Methods of Positioning Region of Interest for ADC Measurements at Diffusion-weighted MR ImagingBlazic, Ivana M.; Lilic, Gordana B.; Gajic, Milan M.
doi: 10.1148/radiol.2016151908pmid: 27253423
To our knowledge, ours is the only study to date in which measurements were acquired in three different ways to predict complete tumor response to combined chemotherapy and radiation therapy, and the percentage of apparent diffusion coefficient (ADC) change measured with the whole-tumor volume method achieved the highest diagnostic performance, with an area under the curve of 0.882, sensitivity of 80% (eight of 10), specificity of 85% (44 of 52), accuracy of 84% (52 of 62), positive predictive value of 50% (eight of 16), and negative predictive value of 96% (44 of 46), by using a 54% ADC increase as the cut-off value.