Kokkinidis, Larry; Anisman, Hymie
doi: 10.1037/0033-2909.88.3.551pmid: N/A
A review of the literature suggests that although some behaviors may be mediated by dopamine (DA) and other behaviors are largely subserved by noradrenergic mechanisms, the elicitation of a given behavior by amphetamine may be influenced by the interaction among several transmitters. It is hypothesized that behaviors that involve norepinephrine (NE) activity are stimulus bound and are related to attentional processes, whereas behaviors primarily subserved by DA appear to be motorically based. Behavioral augmentations frequently observed following repeated drug treatment are postulated to reflect alterations in DA activity, whereas the reduction of the drug's effect is ascribed to changes in attentional processes owing to variations in NE activity. The acute and chronic effects of dextro-amphetamine on attentional and arousal processes are related to current views of drug-induced psychosis in humans and to endogenous disorders. (9½ p ref)