European Journal of Clinical Pharmacology

Gehin, Martine; Sidharta, Patricia; Gnerre, Carmela; Treiber, Alexander; Halabi, Atef; Dingemanse, Jasper

doi: 10.1007/s00228-014-1767-xpmid: 25323804

As setipiprant has little impact on simvastatin pharmacokinetics, it does not modulate CYP3A4 in a clinically relevant manner.

Ling, Jing; Shi, Jun; Jiang, Qiudi; Jiao, Zheng

doi: 10.1007/s00228-014-1771-1pmid: 25327506

This is the first population PK analysis to evaluate ethnic differences in the PK of MPA and MPAG in healthy Chinese and Caucasian subjects. No differences were observed in the PK of MPA between healthy Chinese and Caucasian subjects. Although, the MPAG CL/ F was approximately 40 % higher in Caucasians, this finding may not be clinically relevant.

Gao, Li-chen; Wang, Di; Liu, Fang-qun; Huang, Zheng-yu; Huang, Hong-guang; Wang, Gui-hua; Chen, Xi; Shi, Qun-zhi; Hong, Li; Wu, Li-ping; Tang, Jie

doi: 10.1007/s00228-014-1769-8pmid:

Turkiewicz, Aleksandra; Vicente, Raquel; Ohlsson, Henrik; Tyden, Patrik; Merlo, Juan

doi: 10.1007/s00228-014-1779-6pmid: 25384436

In our opinion, the previously reported increase in risk of adverse cardiac events in patients using PPIs may reflect the fact that an AMI may be misinterpreted as dyspepsia.

Hashi, Sachiyo; Yano, Ikuko; Shibata, Mai; Masuda, Satohiro; Kinoshita, Masako; Matsumoto, Riki; Ikeda, Akio; Takahashi, Ryosuke; Matsubara, Kazuo

doi: 10.1007/s00228-014-1773-zpmid: 25323806

The efficacy of low-dose CLB therapy was significantly influenced by CYP2C19 polymorphisms. Ideally, CLB therapy should be started with a low dose (2.5 mg/day) and dosage increased until N -CLB serum concentration reaches 1100 ng/mL or until the desired effect is acquired, a recommendation that is particularly important for PMs.

Park, Hye; Kim, Sung; Leem, Dong; Moon, Il; Koh, Beom; Park, Kyung; Park, Jung-Won; Lee, Jae-Hyun

doi: 10.1007/s00228-014-1764-0pmid: 25327504

The major SJS/TEN-inducing drugs were found to be allopurinol and anticonvulsants (such as lamotrigine). We speculated that Korean individuals expressing the HLA-B*4403 allele may be highly susceptible to lamotrigine-induced SJS/TEN.

Wang, Yan; Zou, Yamin; Xie, Jiao; Wang, Taotao; Zheng, Xiaowei; He, Hairong; Dong, Weihua; Xing, Jianfeng; Dong, Yalin

doi: 10.1007/s00228-014-1775-xpmid: 25355172

These results suggest that linezolid is not superior to vancomycin with respect to both clinical and microbiological cure rates in patients with MRSA NP.

Magalhães, Joana; Rodrigues, António; Roque, Fátima; Figueiras, Adolfo; Falcão, Amílcar; Herdeiro, Maria

doi: 10.1007/s00228-014-1768-9pmid: 25318905

These findings show that: (i) off-label and/or an unlicensed prescribing is widespread among the hospitalised paediatric population worldwide, (ii) there is no consensus on a definition of off-label and/or unlicensed drugs and (iii) preterm newborns receive most off-label and/or unlicensed drugs. By shedding new light on off-label and/or unlicensed drug prescribing, these findings will hopefully contribute to generating new, more effective knowledge about the paediatric population’s need for quality drugs that are both safe and efficacious.

Tkáč, Ivan; Javorský, Martin; Klimčáková, Lucia; Židzik, Jozef; Gaľa, Igor; Babjaková, Eva; Schroner, Zbynek; Štolfová, Mária; Hermanová, Hana; Habalová, Viera

doi: 10.1007/s00228-014-1774-y

Diepstraten, Jeroen; Janssen, Esther; Hackeng, Christian; Dongen, Eric; Wiezer, René; Ramshorst, Bert; Knibbe, Catherijne

doi: 10.1007/s00228-014-1760-4pmid: 25304008

A pharmacodynamic model was developed characterizing anti-Xa levels after s.c. administration of nadroparin in patients weighing between 72 and 252 kg with TBW and LBW as the major determinants for clearance and volume of distribution, respectively.