European Journal of Clinical Pharmacology

Clay, Emilie; Falissard, Bruno; Moore, Nicholas; Toumi, Mondher

doi: 10.1007/s00228-012-1424-1pmid: 23114457

Campaigns aiming to reduce the use of BZD/Z-drugs failed when they were not associated with the availability and market uptake of PR-melatonin. The reimbursement of PR-melatonin supports better penetration rates and a higher reduction in sales for BZD/Z-drugs.

Elyasi, Sepideh; Khalili, Hossein; Hatamkhani, Shima; Dashti-Khavidaki, Simin

doi: 10.1007/s00228-012-1406-3pmid: 22996076

Animal studies show beneficial effects of various antioxidants, such as erdosteine, vitamin E, vitamin C, N -acetylcysteine, caffeic acid phenethyl ester, and erythropoietin, in the prevention of vancomycin-induced nephrotoxicity. However, before these agents can be used in clinical practice, their potential benefits must be confirmed in future randomized controlled human studies.

Cooke, M.; Waring, W.

doi: 10.1007/s00228-012-1408-1pmid: 22996077

A dose-effect relationship for QT prolongation exists across a broad range of citalopram doses, such that caution must be exercised when prescribing high doses or if there are co-existent risk factors for QT effects. The available data illustrate how clinical toxicity data may offer an earlier signal of cardiac effects than ascertained from conventional pharmacovigilance methods.

Camp, Yoleen; Rompaey, Bart; Elseviers, Monique

doi: 10.1007/s00228-012-1419-ypmid: 23052418

Counselling appears to be an effective approach that nurses can use to supplement other methods, building a multifaceted strategy to enhance adherence. Tackling non-adherence seems to demand continuous efforts and follow-up.

Zou, Jian-Jun; Xie, Hong-Guang; Chen, Shao-Liang; Tan, Jie; Lin, Ling; Zhao, Ying-Ying; Xu, Hai-Mei; Lin, Song; Zhang, Juan; Wang, Guang-Ji

doi: 10.1007/s00228-012-1392-5pmid: 23001453

Chevassus, Hugues; Farret, Anne; Gagnol, Jean-Pierre; Ponçon, Claire-Anne; Costa, Françoise; Roux, Clarisse; Galtier, Florence; Petit, Pierre

doi: 10.1007/s00228-012-1418-zpmid: 23052417

Although it may not share all the properties of stimulant drugs, the effect profile of bupropion presents a number of similarities with that of methylphenidate over a 2-week treatment period.

Santos, Paulo; Dinardo, Carla; Schettert, Isolmar; Soares, Renata; Kawabata-Yoshihara, Liz; Bensenor, Isabela; Krieger, José; Lotufo, Paulo; Pereira, Alexandre

doi: 10.1007/s00228-012-1404-5pmid: 22990331

Chan, Sze; Hu, Miao; Ko, Sara; Tam, Catherine; Fok, Benny; Yin, Ophelia; Chow, Moses; Tomlinson, Brian

doi: 10.1007/s00228-012-1428-xpmid: 23090703

Our results suggest that the PK of labetalol are significantly affected by the common CYP2C19 polymorphisms in individuals of Chinese ethnicity. Future larger studies are needed to evaluate the effect of CYP2C19 and UGT1A1 polymorphisms on the PK of labetalol stereoisomers and the pharmacodynamic effects.

Zhang, Jing-Jing; Zhang, Hua; Ding, Xiao-Liang; Ma, Sheng; Miao, Li-Yan

doi: 10.1007/s00228-012-1432-1pmid: 23097010

The POR*28 CT genotype presented a significantly lower level of tacrolimus exposure (AUC, C max ) compared with the POR*28 CC genotype in CYP3A5-expressing subjects. It suggested that the POR*28 genetic polymorphism might also be responsible for the marked interindividual variability of tacrolimus besides the CYP3A5*3 genetic polymorphism.

Giles, Francis; Yin, Ophelia; Sallas, William; Coutre, Philipp; Woodman, Richard; Ottmann, Oliver; Baccarani, Michele; Kantarjian, Hagop

doi: 10.1007/s00228-012-1385-4pmid: 23052406

When tolerability allows, adherence to the nilotinib dose (400 mg twice daily) in order to maintain sufficient C min is important in maximizing the efficacy of nilotinib in patients with imatinib-resistant or -intolerant CML.