European Journal of Clinical Pharmacology

Frank, D.; Jaehde, U.; Fuhr, U.

doi: 10.1007/s00228-006-0250-8pmid: 17273835

Application of the validation criteria suggests that dextromethorphan and debrisoquine are the best CYP2D6 phenotyping drugs, with debrisoquine having the problem of very limited availability as a therapeutic drug. However, the assessment of the best dextromethorphan CYP2D6 phenotyping metric/procedure is still ongoing.

Schalekamp, Tom; Geest-Daalderop, Johanna; Kramer, Mark; Holten-Verzantvoort, Angelique; Boer, Anthonius

doi: 10.1007/s00228-007-0268-6pmid: 17318526

PDR is effective in preventing overanticoagulation in co-trimoxazole users, but results in a significantly prolonged period of underanticoagulation after the course. Avoidance of concomitant use of co-trimoxazole with acenocoumarol or phenprocoumon seems to be a safer approach than management of the interaction between these drugs.

Nakao, Masashi; Muramoto, Yousuke; Hisadome, Motoko; Yamano, Naoko; Shoji, Mami; Fukushima, Yumi; Saruwatari, Junji; Nakagawa, Kazuko

doi: 10.1007/s00228-006-0253-5pmid: 17297618

Our results indicate that TJ-19 at the generally recommended dosage is unlikely to cause pharmacokinetic interaction with co-administered medications primarily dependent on the CYP1A2, CYP2D6, CYP3A, XO, and NAT2 pathways for elimination.

Soppi, Ville; Kokki, Hannu; Koivisto, Timo; Lehtonen, Marko; Helin-Tanninen, Minna; Lehtola, Sanna; Rinne, Jaakko

doi: 10.1007/s00228-007-0267-7pmid: 17318527

This pilot study indicates that the rate and extent of nimopidine absorption following enteral administration in some acute SAH patients could be negligible, and this may particularly be the case in patients with a decreased level of consciousness.

Källén, Bengt; Otterblad Olausson, Petra

doi: 10.1007/s00228-006-0257-1pmid: 17265060

An increase risk of pregnancy complications occurs with the use of anti-asthmatic drugs by pregnant women, which results in an increased rate of caesarean sections.

Källén, Bengt; Olausson, Petra

doi: 10.1007/s00228-006-0258-0pmid: 17265059

Infants whose mothers had asthma had a number of manifestations of poor outcome which appeared to be linked with the severity of the asthma.

Källén, Bengt; Olausson, Petra

doi: 10.1007/s00228-006-0259-zpmid: 17279357

Maternal asthma and use of anti-asthmatic drugs carry no major risk for congenital malformations in the offspring, but a slight teratogenic effect cannot be excluded. It may be due to asthma, and arguments for a stronger effect of inhaled corticosteroids than of other anti-asthmatics are weak.

Onder, Graziano; Liperoti, Rosa; Russo, Andrea; Capoluongo, Ettore; Minucci, Angelo; Lulli, Paola; Cesari, Matteo; Maggio, Marcello; Bernabei, Roberto; Landi, Francesco

doi: 10.1007/s00228-007-0262-zpmid:

Abaci, Adnan; Kozan, Omer; Oguz, Aytekin; Sahin, Mahmut; Deger, Necmi; Senocak, Huseyin; Toprak, Nizamettin; Sur, Haydar; Erol, Cetin

doi: 10.1007/s00228-007-0266-8pmid: 17279356

As in other European countries, the rate of successful blood pressure control was low among hypertensive patients receiving treatment, and despite the inadequacy of monotherapy to control blood pressure, many of the patients continued this treatment regimen. Consistent with the global trend, the most frequently prescribed anti-hypertensives were angiotensin blockers.

Helin-Salmivaara, Arja; Huttunen, Teppo; Grönroos, Juha; Klaukka, Timo; Huupponen, Risto

doi: 10.1007/s00228-007-0263-ypmid: 17347805

The concurrent use of SSRIs and NSAIDs is associated with a moderate excess relative risk of a serious upper GI event when compared with NSAID use alone.