The New England Journal of Medicine

Kunchok, Amy; McKeon, Andrew

doi: 10.1056/NEJMicm1914516pmid: 32966725

Opsoclonus in Anti-Ma2 Brain-Stem EncephalitisA 71-year-old man presented with a 3-month history of vertigo, diplopia, and ataxia. He had rapid, nonrhythmic, saccadic, and multidirectional ocular movements (shown in a video), a condition known as opsoclonus. Serum was positive for Ma2 IgG antibodies.

Cuneo, C. Nicholas; Janeway, Hannah

doi: 10.1056/NEJMp2009985pmid: 32757518

From Icebox to TinderboxThe situation on the U.S.–Mexico border is a public health crisis of our country’s own manufacturing, the result of a zealous effort to shirk our responsibility to people fleeing persecution, whom we have instead chosen to put directly in harm’s way.

Teasdale, Ben; Schulman, Kevin A.

doi: 10.1056/NEJMp2018846pmid: 32610005

Are U.S. Hospitals Still “Recession-proof”?Key changes within hospitals’ cost structures have led them to an economic precipice. Hospitals were vulnerable to economic downturns before the first Covid-19 cases were detected and, barring a correction, will remain so long after the epidemic runs its course.

Rubin, Eric J.; Baden, Lindsey R.; Morrissey, Stephen

doi: 10.1056/NEJMe2030336pmid: 32966738

Eight Months of Action and Inaction against Covid-19In this audio interview conducted on September 23, 2020, as global deaths near 1 million and U.S. deaths pass 200,000, the editors reflect on 8 months of action and inaction against Covid-19.

Studdert, David M.; Hall, Mark A.; Mello, Michelle M.

doi: 10.1056/NEJMp2024274pmid: 32757517

Partitioning the CurveMany jurisdictions have responded to the unevenness of the unfolding Covid-19 pandemic by battening down their borders. But within the United States, attempts to restrict interstate travel present distinctive legal issues.

doi: 10.1056/NEJMtwj200924pmid: N/A

Issue HighlightsIssue Highlights, September 24, 2020A RAS Inhibitor at LastAvelumab Therapy in Bladder CancerLower-Dose Zinc for Childhood DiarrheaCAH Due to 21-Hydroxylase DeficiencyVisions of the Future of Health Policy

Fiedler, Matthew

doi: 10.1056/NEJMp2018759pmid: 32966718

Competing Visions for the Future of Health PolicyBeyond Covid-19, two other health policy issues are poised to feature prominently in the 2020 U.S. elections: what role government should play in ensuring broad health insurance coverage, and how to cope with the lack of competition in many health care provider markets.

Chong, William H.; Yanoff, Lisa B.; Andraca-Carrera, Eugenio; Thanh Hai, Mary

doi: 10.1056/NEJMp2004889pmid: 32966719

Assessing the Safety of Glucose-Lowering DrugsThe FDA is moving away from a narrow focus on evaluating the cardiovascular safety of drugs for glycemic control and recommending that such drugs be studied in broad, representative populations of patients to permit a meaningful assessment of various potential risks.

Christie, Athalia; Neatherlin, John C.; Nichol, Stuart T.; Beach, Michael; Redfield, Robert R.

doi: 10.1056/NEJMp2025512pmid: 32966720

Ebola Response Priorities in the Time of Covid-19Although the 10th outbreak of Ebola virus disease in the Democratic Republic of Congo was declared over in late June 2020, additional cases attributable to persistently infected survivors may occur. Therefore, surveillance and rapid-response capacity should be maintained.

Wayman, Katherine A.

doi: 10.1056/NEJMp2002103pmid: 32966721

A Farewell Gift from My Mother“If I can’t sit on the floor and play with my grandsons, I don’t want to live.” My mother made it clear she valued her mobility, her golf game, and her language. If there were no treatments that could ensure all those abilities, she wanted to be allowed to die.