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Journal of Neurophysiology | DeepDyve

Journal of Neurophysiology

Subject:: Physiology
Publisher:: The American Physiological Society
ISSN:: 0022-3077
Scimago Journal Rank:: 252

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A translational approach for understanding hyperalgesia: What has the high-frequency electrical stimulation model taught us?

van den Broeke, Emanuel N.

2024 Journal of Neurophysiology

doi: 10.1152/jn.00407.2024pmid: 39475489

High-frequency electrical stimulation (HFS) of C fiber nociceptors induces long-term potentiation (LTP) at the first spinal synapse. This spinal LTP is believed to play a role in the amplification of pain. However, the effects of HFS are probably not restricted to the spinal cord. A recent study showed that HFS increases cortical responses to noxious stimuli in a porcine model. Are these increased cortical responses a correlate of spinal LTP and do we observe the same in humans?

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