Journal of Neurophysiology

Stephanie Rudolph, Monica S. Thanawala

doi: 10.1152/jn.00181.2014pmid: 25185803

Abstract Voltage-dependent calcium channels (VDCCs) couple neuronal activity to diverse intracellular signals with exquisite spatiotemporal specificity. Using calcium imaging and electrophysiology, Jones and Stuart ( J Neurosci 33: 19396–19405, 2013) examined the intimate relationship between distinct types of VDCCs and small-conductance calcium-activated potassium (SK) channels that contribute to the compartmentalized control of excitability in the soma and dendrites of cortical pyramidal neurons. Here we discuss the importance of calcium domains for signal specificity, explore the possible functions and mechanisms for local control of SK channels, and highlight technical considerations for the optical detection of calcium signals. SK channel calcium domains calcium buffering neuronal excitability Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords SK channel calcium domains calcium buffering neuronal excitability Article Abstract DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Location matters: somatic and dendritic SK channels answer to distinct calcium signals Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Location matters: somatic and dendritic SK channels answer to distinct calcium signals Stephanie Rudolph , Monica S. Thanawala Journal of Neurophysiology Jul 2015, 114 (1) 1-5; DOI: 10.1152/jn.00181.2014 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Location matters: somatic and dendritic SK channels answer to distinct calcium signals Stephanie Rudolph , Monica S. Thanawala Journal of Neurophysiology Jul 2015, 114 (1) 1-5; DOI: 10.1152/jn.00181.2014 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Non-invasive brain stimulation enhances sustained muscle contractions by reducing neuromuscular fatigue: Implications for rehabilitation Neuromodulatory influence of norepinephrine during developmental experience-dependent plasticity A step towards understanding the human ventral visual pathway Show more Neuro Forum Related Articles Web of Science Scopus PubMed Google Scholar Cited By... No citing articles found. Web of Science (2) Scopus (2) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Michal Israelashvili, Yocheved Loewenstern, Izhar Bar-Gad

doi: 10.1152/jn.00277.2015pmid: 25925326

Abstract Tourette syndrome (TS) is a common childhood-onset disorder characterized by motor and vocal tics that are typically accompanied by a multitude of comorbid symptoms. Pharmacological treatment options are limited, which has led to the exploration of deep brain stimulation (DBS) as a possible treatment for severe cases. Multiple lines of evidence have linked TS with abnormalities in the motor and limbic cortico-basal ganglia (CBG) pathways. Neurophysiological data have only recently started to slowly accumulate from multiple sources: noninvasive imaging and electrophysiological techniques, invasive electrophysiological recordings in TS patients undergoing DBS implantation surgery, and animal models of the disorder. These converging sources point to system-level physiological changes throughout the CBG pathway, including both general altered baseline neuronal activity patterns and specific tic-related activity. DBS has been applied to different regions along the motor and limbic pathways, primarily to the globus pallidus internus, thalamic nuclei, and nucleus accumbens. In line with the findings that also draw on the more abundant application of DBS to Parkinson's disease, this stimulation is assumed to result in changes in the neuronal firing patterns and the passage of information through the stimulated nuclei. We present an overview of recent experimental findings on abnormal neuronal activity associated with TS and the changes in this activity following DBS. These findings are then discussed in the context of current models of CBG function in the normal state, during TS, and finally in the wider context of DBS in CBG-related disorders. deep brain stimulation motor tics Tourette syndrome neurophysiology basal ganglia Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords deep brain stimulation motor tics Tourette syndrome neurophysiology basal ganglia Article Abstract GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Your Personal Message Print Citation Tools Abnormal neuronal activity in Tourette syndrome and its modulation using deep brain stimulation Michal Israelashvili , Yocheved Loewenstern , Izhar Bar-Gad Journal of Neurophysiology Jul 2015, 114 (1) 6-20; DOI: 10.1152/jn.00277.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Abnormal neuronal activity in Tourette syndrome and its modulation using deep brain stimulation Michal Israelashvili , Yocheved Loewenstern , Izhar Bar-Gad Journal of Neurophysiology Jul 2015, 114 (1) 6-20; DOI: 10.1152/jn.00277.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Strategies for targeting primate neural circuits with viral vectors Voltage imaging to understand connections and functions of neuronal circuits Show more Call for Papers Related Articles Web of Science Scopus PubMed Google Scholar Cited By... Common therapeutic mechanisms of pallidal deep brain stimulation for hypo- and hyperkinetic movement disorders Abstract Fulltext PDF Web of Science (1) Scopus (1) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Toshiyuki Kano, Yuji Inaba, Margherita D'Antuono, Giuseppe Biagini, Maxime Levésque, Massimo Avoli

doi: 10.1152/jn.00248.2015pmid: 25925325

Abstract Low-frequency stimulation, delivered through transcranial magnetic or deep-brain electrical procedures, reduces seizures in patients with pharmacoresistant epilepsy. A similar control of ictallike discharges is exerted by low-frequency electrical stimulation in rodent brain slices maintained in vitro during convulsant treatment. By employing field and “sharp” intracellular recordings, we analyzed here the effects of stimuli delivered at 0.1 or 1 Hz in the lateral nucleus of the amygdala on ictallike epileptiform discharges induced by the K + channel blocker 4-aminopyridine in the perirhinal cortex, in a rat brain slice preparation. We found that 1 ) ictal events were nominally abolished when the stimulus rate was brought from 0.1 to 1 Hz; 2 ) this effect was associated with an increased latency of the epileptiform responses recorded in perirhinal cortex following each stimulus; and 3 ) both changes recovered to control values following arrest of the 1-Hz stimulation protocol. The control of ictal activity by 1-Hz stimulation and the concomitant latency increase were significantly reduced by GABA B receptor antagonism. We propose that this frequency-dependent increase in latency represents a short-lasting, GABA B receptor-dependent adaptive mechanism that contributes to decrease epileptiform synchronization, thus blocking seizures in epileptic patients and animal models. amygdala ictogenesis perirhinal cortex repetitive stimulation Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords amygdala Ictogenesis Perirhinal Cortex Repetitive Stimulation Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Blockade of in vitro ictogenesis by low-frequency stimulation coincides with increased epileptiform response latency Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Blockade of in vitro ictogenesis by low-frequency stimulation coincides with increased epileptiform response latency Toshiyuki Kano , Yuji Inaba , Margherita D'Antuono , Giuseppe Biagini , Maxime Levésque , Massimo Avoli Journal of Neurophysiology Jul 2015, 114 (1) 21-28; DOI: 10.1152/jn.00248.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Blockade of in vitro ictogenesis by low-frequency stimulation coincides with increased epileptiform response latency Toshiyuki Kano , Yuji Inaba , Margherita D'Antuono , Giuseppe Biagini , Maxime Levésque , Massimo Avoli Journal of Neurophysiology Jul 2015, 114 (1) 21-28; DOI: 10.1152/jn.00248.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Strategies for targeting primate neural circuits with viral vectors Voltage imaging to understand connections and functions of neuronal circuits Show more Call for Papers Related Articles Web of Science Scopus PubMed Google Scholar Cited By... No citing articles found. Scopus (1) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Max-Philipp Stenner, Vladimir Litvak, Robb B. Rutledge, Tino Zaehle, Friedhelm C. Schmitt, Jürgen Voges, Hans-Jochen Heinze, Raymond J. Dolan

doi: 10.1152/jn.00988.2014pmid: 25878159

Abstract The nucleus accumbens is thought to contribute to action selection by integrating behaviorally relevant information from multiple regions, including prefrontal cortex. Studies in rodents suggest that information flow to the nucleus accumbens may be regulated via task-dependent oscillatory coupling between regions. During instrumental behavior, local field potentials (LFP) in the rat nucleus accumbens and prefrontal cortex are coupled at delta frequencies (Gruber AJ, Hussain RJ, O'Donnell P. PLoS One 4: e5062, 2009), possibly mediating suppression of afferent input from other areas and thereby supporting cortical control (Calhoon GG, O'Donnell P. Neuron 78: 181–190, 2013). In this report, we demonstrate low-frequency cortico-accumbens coupling in humans, both at rest and during a decision-making task. We recorded LFP from the nucleus accumbens in six epilepsy patients who underwent implantation of deep brain stimulation electrodes. All patients showed significant coherence and phase-synchronization between LFP and surface EEG at delta and low theta frequencies. Although the direction of this coupling as indexed by Granger causality varied between subjects in the resting-state data, all patients showed a cortical drive of the nucleus accumbens during action selection in a decision-making task. In three patients this was accompanied by a significant coherence increase over baseline. Our results suggest that low-frequency cortico-accumbens coupling represents a highly conserved regulatory mechanism for action selection. nucleus accumbens action selection local field potentials synchronization deep brain stimulation Copyright © 2015 the American Physiological Society Licensed under Creative Commons Attribution CC-BY 3.0 : © the American Physiological Society. View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords nucleus accumbens action selection local field potentials synchronization deep brain stimulation Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Cortical drive of low-frequency oscillations in the human nucleus accumbens during action selection Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Cortical drive of low-frequency oscillations in the human nucleus accumbens during action selection Max-Philipp Stenner , Vladimir Litvak , Robb B. Rutledge , Tino Zaehle , Friedhelm C. Schmitt , Jürgen Voges , Hans-Jochen Heinze , Raymond J. Dolan Journal of Neurophysiology Jul 2015, 114 (1) 29-39; DOI: 10.1152/jn.00988.2014 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Cortical drive of low-frequency oscillations in the human nucleus accumbens during action selection Max-Philipp Stenner , Vladimir Litvak , Robb B. Rutledge , Tino Zaehle , Friedhelm C. Schmitt , Jürgen Voges , Hans-Jochen Heinze , Raymond J. Dolan Journal of Neurophysiology Jul 2015, 114 (1) 29-39; DOI: 10.1152/jn.00988.2014 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Strategies for targeting primate neural circuits with viral vectors Voltage imaging to understand connections and functions of neuronal circuits Show more Call for Papers Related Articles Web of Science Scopus PubMed Google Scholar Cited By... No citing articles found. Web of Science (1) Scopus (1) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Guy E. Hawkins, Eric-Jan Wagenmakers, Roger Ratcliff, Scott D. Brown

doi: 10.1152/jn.00088.2015pmid: 25904706

Abstract The dominant theoretical paradigm in explaining decision making throughout both neuroscience and cognitive science is known as “evidence accumulation”—the core idea being that decisions are reached by a gradual accumulation of noisy information. Although this notion has been supported by hundreds of experiments over decades of study, a recent theory proposes that the fundamental assumption of evidence accumulation requires revision. The “urgency gating” model assumes decisions are made without accumulating evidence, using only moment-by-moment information. Under this assumption, the successful history of evidence accumulation models is explained by asserting that the two models are mathematically identical in standard experimental procedures. We demonstrate that this proof of equivalence is incorrect, and that the models are not identical, even when both models are augmented with realistic extra assumptions. We also demonstrate that the two models can be perfectly distinguished in realistic simulated experimental designs, and in two real data sets; the evidence accumulation model provided the best account for one data set, and the urgency gating model for the other. A positive outcome is that the opposing modeling approaches can be fruitfully investigated without wholesale change to the standard experimental paradigms. We conclude that future research must establish whether the urgency gating model enjoys the same empirical support in the standard experimental paradigms that evidence accumulation models have gathered over decades of study. decision-making response time mathematical model urgency gating evidence accumulation Footnotes Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords decision-making response time mathematical model Urgency gating Evidence accumulation Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS Footnotes REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Discriminating evidence accumulation from urgency signals in speeded decision making Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Discriminating evidence accumulation from urgency signals in speeded decision making Guy E. Hawkins , Eric-Jan Wagenmakers , Roger Ratcliff , Scott D. Brown Journal of Neurophysiology Jul 2015, 114 (1) 40-47; DOI: 10.1152/jn.00088.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Discriminating evidence accumulation from urgency signals in speeded decision making Guy E. Hawkins , Eric-Jan Wagenmakers , Roger Ratcliff , Scott D. Brown Journal of Neurophysiology Jul 2015, 114 (1) 40-47; DOI: 10.1152/jn.00088.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Strategies for targeting primate neural circuits with viral vectors Voltage imaging to understand connections and functions of neuronal circuits Show more Call for Papers Related Articles Web of Science Scopus PubMed Google Scholar Cited By... How to discriminate conclusively among different models of decision making? Abstract Fulltext PDF Evidence against perfect integration of sensory information during perceptual decision making Abstract Fulltext PDF On the difference between evidence accumulator models and the urgency gating model Abstract Fulltext PDF Modulation of Premotor and Primary Motor Cortical Activity during Volitional Adjustments of Speed-Accuracy Trade-Offs Abstract Fulltext PDF Combining Computational Models of Cognition and Neural Data to Learn about Mixed Task Strategies Abstract Fulltext PDF Web of Science (6) Scopus (6) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Aldo Genovesio, Rossella Cirillo, Satoshi Tsujimoto, Sara Mohammad Abdellatif, Steven P. Wise

doi: 10.1152/jn.00057.2015pmid: 25904705

Abstract Rhesus monkeys performed two tasks, both requiring a choice between a red square and a blue circle. In the duration task, the two stimuli appeared sequentially on each trial, for varying durations, and, later, during the choice phase of the task, the monkeys needed to choose the one that had lasted longer. In the matching-to-sample task, one of the two stimuli appeared twice as a sample, with durations matching those in the duration task, and the monkey needed to choose that stimulus during the choice phase. Although stimulus duration was irrelevant in the matching-to-sample task, the monkeys made twice as many errors when the second stimulus was shorter. This across-task interference supports an order-dependent model of the monkeys' choice and reveals something about their strategy in the duration task. The monkeys tended to choose the second stimulus when its duration exceeded the first and to choose the alternative stimulus otherwise. For the duration task, this strategy obviated the need to store stimulus-duration conjunctions for both stimuli, but it generated errors on the matching-to-sample task. We examined duration coding in prefrontal neurons and confirmed that a population of cells encoded relative duration during the matching-to-sample task, as expected from the order-dependent errors. prefrontal decision monkey interference timing Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords prefrontal decision monkey interference timing Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Automatic comparison of stimulus durations in the primate prefrontal cortex: the neural basis of across-task interference Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Automatic comparison of stimulus durations in the primate prefrontal cortex: the neural basis of across-task interference Aldo Genovesio , Rossella Cirillo , Satoshi Tsujimoto , Sara Mohammad Abdellatif , Steven P. Wise Journal of Neurophysiology Jul 2015, 114 (1) 48-56; DOI: 10.1152/jn.00057.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Automatic comparison of stimulus durations in the primate prefrontal cortex: the neural basis of across-task interference Aldo Genovesio , Rossella Cirillo , Satoshi Tsujimoto , Sara Mohammad Abdellatif , Steven P. Wise Journal of Neurophysiology Jul 2015, 114 (1) 48-56; DOI: 10.1152/jn.00057.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Strategies for targeting primate neural circuits with viral vectors Voltage imaging to understand connections and functions of neuronal circuits Show more Call for Papers Related Articles Web of Science PubMed Google Scholar Cited By... Neural Encoding of Self and Another Agent's Goal in the Primate Prefrontal Cortex: Human-Monkey Interactions Abstract Fulltext PDF Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Hanna Heikkinen, Fariba Sharifian, Ricardo Vigario, Simo Vanni

doi: 10.1152/jn.00169.2015pmid: 25925319

Abstract The blood oxygenation level-dependent (BOLD) response has been strongly associated with neuronal activity in the brain. However, some neuronal tuning properties are consistently different from the BOLD response. We studied the spatial extent of neural and hemodynamic responses in the primary visual cortex, where the BOLD responses spread and interact over much longer distances than the small receptive fields of individual neurons would predict. Our model shows that a feedforward-feedback loop between V1 and a higher visual area can account for the observed spread of the BOLD response. In particular, anisotropic landing of inputs to compartmental neurons were necessary to account for the BOLD signal spread, while retaining realistic spiking responses. Our work shows that simple dendrites can separate tuning at the synapses and at the action potential output, thus bridging the BOLD signal to the neural receptive fields with high fidelity. fMRI hemodynamic coupling V1 visual cortex BOLD Brian simulator dendritic processing recurrent neural network conductance-based model BOLD simulation Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords fMRI hemodynamic coupling V1 visual cortex BOLD Brian simulator dendritic processing recurrent neural network conductance-based model BOLD simulation Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Feedback to distal dendrites links fMRI signals to neural receptive fields in a spiking network model of the visual cortex Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Feedback to distal dendrites links fMRI signals to neural receptive fields in a spiking network model of the visual cortex Hanna Heikkinen , Fariba Sharifian , Ricardo Vigario , Simo Vanni Journal of Neurophysiology Jul 2015, 114 (1) 57-69; DOI: 10.1152/jn.00169.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Feedback to distal dendrites links fMRI signals to neural receptive fields in a spiking network model of the visual cortex Hanna Heikkinen , Fariba Sharifian , Ricardo Vigario , Simo Vanni Journal of Neurophysiology Jul 2015, 114 (1) 57-69; DOI: 10.1152/jn.00169.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Strategies for targeting primate neural circuits with viral vectors Voltage imaging to understand connections and functions of neuronal circuits Show more Call for Papers Related Articles Web of Science Scopus PubMed Google Scholar Cited By... Modeling fMRI signals can provide insights into neural processing in the cerebral cortex Abstract Fulltext PDF Web of Science (3) Scopus (2) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Abigail Z. Rajala, Rick L. Jenison, Luis C. Populin

doi: 10.1152/jn.00278.2015pmid: 25972584

Abstract Decisions are often made based on which option will result in the largest reward. When given a choice between a smaller but immediate reward and a larger delayed reward, however, humans and animals often choose the smaller, an effect known as temporal discounting. Dopamine (DA) neurotransmission is central to reward processing and encodes delayed reward value. Impulsivity, the tendency to act without forethought, is associated with excessive discounting of rewards, which has been documented in patients with attention deficit hyperactivity disorder (ADHD). Both impulsivity and temporal discounting are linked to the dopaminergic system. Methylphenidate (MPH), which blocks the DA transporter and increases extracellular levels of DA in the basal ganglia and prefrontal cortex, is a primary treatment for ADHD and, at low doses, ameliorates impulsivity in both humans and animals. This study tested the hypothesis that low doses of MPH would decrease the discounting rate of rhesus monkeys performing an intertemporal choice task, suggesting a reduction in impulsivity. The results support this hypothesis and provide further evidence for the role of DA in temporal discounting and impulsive behavior. monkey impulsivity temporal discounting hyperbolic methylphenidate Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords monkey impulsivity temporal discounting hyperbolic methylphenidate Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ENDNOTE ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Decision making: effects of methylphenidate on temporal discounting in nonhuman primates Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Decision making: effects of methylphenidate on temporal discounting in nonhuman primates Abigail Z. Rajala , Rick L. Jenison , Luis C. Populin Journal of Neurophysiology Jul 2015, 114 (1) 70-79; DOI: 10.1152/jn.00278.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Decision making: effects of methylphenidate on temporal discounting in nonhuman primates Abigail Z. Rajala , Rick L. Jenison , Luis C. Populin Journal of Neurophysiology Jul 2015, 114 (1) 70-79; DOI: 10.1152/jn.00278.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Strategies for targeting primate neural circuits with viral vectors Voltage imaging to understand connections and functions of neuronal circuits Show more Call for Papers Related Articles Web of Science Scopus PubMed Google Scholar Cited By... No citing articles found. Web of Science (2) Scopus (2) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Jackson E. T. Smith, Vincent Beliveau, Alan Schoen, Jordana Remz, Chang'an A. Zhan, Erik P. Cook

doi: 10.1152/jn.00058.2015pmid: 25948867

Abstract The evolution of a visually guided perceptual decision results from multiple neural processes, and recent work suggests that signals with different neural origins are reflected in separate frequency bands of the cortical local field potential (LFP). Spike activity and LFPs in the middle temporal area (MT) have a functional link with the perception of motion stimuli (referred to as neural-behavioral correlation). To cast light on the different neural origins that underlie this functional link, we compared the temporal dynamics of the neural-behavioral correlations of MT spikes and LFPs. Wide-band activity was simultaneously recorded from two locations of MT from monkeys performing a threshold, two-stimuli, motion pulse detection task. Shortly after the motion pulse occurred, we found that high-gamma (100–200 Hz) LFPs had a fast, positive correlation with detection performance that was similar to that of the spike response. Beta (10–30 Hz) LFPs were negatively correlated with detection performance, but their dynamics were much slower, peaked late, and did not depend on stimulus configuration or reaction time. A late change in the correlation of all LFPs across the two recording electrodes suggests that a common input arrived at both MT locations prior to the behavioral response. Our results support a framework in which early high-gamma LFPs likely reflected fast, bottom-up, sensory processing that was causally linked to perception of the motion pulse. In comparison, late-arriving beta and high-gamma LFPs likely reflected slower, top-down, sources of neural-behavioral correlation that originated after the perception of the motion pulse. behavior cortex local field potential MT vision Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords behavior cortex local field potential MT vision Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Dynamics of the functional link between area MT LFPs and motion detection Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Dynamics of the functional link between area MT LFPs and motion detection Jackson E. T. Smith , Vincent Beliveau , Alan Schoen , Jordana Remz , Chang'an A. Zhan , Erik P. Cook Journal of Neurophysiology Jul 2015, 114 (1) 80-98; DOI: 10.1152/jn.00058.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Dynamics of the functional link between area MT LFPs and motion detection Jackson E. T. Smith , Vincent Beliveau , Alan Schoen , Jordana Remz , Chang'an A. Zhan , Erik P. Cook Journal of Neurophysiology Jul 2015, 114 (1) 80-98; DOI: 10.1152/jn.00058.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Strategies for targeting primate neural circuits with viral vectors Voltage imaging to understand connections and functions of neuronal circuits Show more Call for Papers Related Articles Web of Science PubMed Google Scholar Cited By... No citing articles found. Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Ziqiang Wei, Xiao-Jing Wang

doi: 10.1152/jn.00793.2014pmid: 25948870

Abstract Evaluation of confidence about one's knowledge is key to the brain's ability to monitor cognition. To investigate the neural mechanism of confidence assessment, we examined a biologically realistic spiking network model and found that it reproduced salient behavioral observations and single-neuron activity data from a monkey experiment designed to study confidence about a decision under uncertainty. Interestingly, the model predicts that changes of mind can occur in a mnemonic delay when confidence is low; the probability of changes of mind increases (decreases) with task difficulty in correct (error) trials. Furthermore, a so-called “hard-easy effect” observed in humans naturally emerges, i.e., behavior shows underconfidence (underestimation of correct rate) for easy or moderately difficult tasks and overconfidence (overestimation of correct rate) for very difficult tasks. Importantly, in the model, confidence is computed using a simple neural signal in individual trials, without explicit representation of probability functions. Therefore, even a concept of metacognition can be explained by sampling a stochastic neural activity pattern. decision confidence lateral intraparietal cortex line-attractor neural model Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords Decision confidence Lateral intraparietal cortex Line-attractor neural model Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Your Personal Message Print Citation Tools Confidence estimation as a stochastic process in a neurodynamical system of decision making Ziqiang Wei , Xiao-Jing Wang Journal of Neurophysiology Jul 2015, 114 (1) 99-113; DOI: 10.1152/jn.00793.2014 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Confidence estimation as a stochastic process in a neurodynamical system of decision making Ziqiang Wei , Xiao-Jing Wang Journal of Neurophysiology Jul 2015, 114 (1) 99-113; DOI: 10.1152/jn.00793.2014 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Computational modeling indicates that surface pressure can be reliably conveyed to tactile receptors even amidst changes in skin mechanics Strategies for targeting primate neural circuits with viral vectors Voltage imaging to understand connections and functions of neuronal circuits Show more Call for Papers Related Articles Web of Science Scopus PubMed Google Scholar Cited By... No citing articles found. Web of Science (4) Scopus (3) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598