Journal of Neurophysiology

Joachim Morrens

doi: 10.1152/jn.00751.2013pmid: 24572096

Abstract Dopamine midbrain neurons are well known for prediction error coding in a reward context. A recent report by Christopher Fiorillo ( Science 341: 546–549, 2013), however, suggests that these neurons behave markedly different when subjects get confronted with aversive, rather than appetitive, stimuli. Despite his findings being in line with indications of appetitive and aversive stimuli being processed by distinct neurotransmitter systems, they should still be interpreted with some caution due to a potential issue of recording location. dopamine reinforcement learning reward prediction error ventral tegmental area substantia nigra pars compacta Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords dopamine reinforcement learning reward prediction error ventral tegmental area substantia nigra pars compacta Article Abstract DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Dopamine neurons coding prediction errors in reward space, but not in aversive space: a matter of location? Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Dopamine neurons coding prediction errors in reward space, but not in aversive space: a matter of location? Joachim Morrens Journal of Neurophysiology Sep 2014, 112 (5) 1021-1024; DOI: 10.1152/jn.00751.2013 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Dopamine neurons coding prediction errors in reward space, but not in aversive space: a matter of location? Joachim Morrens Journal of Neurophysiology Sep 2014, 112 (5) 1021-1024; DOI: 10.1152/jn.00751.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Non-invasive brain stimulation enhances sustained muscle contractions by reducing neuromuscular fatigue: Implications for rehabilitation Neuromodulatory influence of norepinephrine during developmental experience-dependent plasticity A step towards understanding the human ventral visual pathway Show more Neuro Forum Related Articles Web of Science Scopus PubMed Google Scholar Cited By... No citing articles found. Web of Science (1) Scopus (1) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Jérôme Bourien, Yong Tang, Charlène Batrel, Antoine Huet, Marc Lenoir, Sabine Ladrech, Gilles Desmadryl, Régis Nouvian, Jean-Luc Puel, Jing Wang

doi: 10.1152/jn.00738.2013pmid: 24848461

Abstract Sound-evoked compound action potential (CAP), which captures the synchronous activation of the auditory nerve fibers (ANFs), is commonly used to probe deafness in experimental and clinical settings. All ANFs are believed to contribute to CAP threshold and amplitude: low sound pressure levels activate the high-spontaneous rate (SR) fibers, and increasing levels gradually recruit medium- and then low-SR fibers. In this study, we quantitatively analyze the contribution of the ANFs to CAP 6 days after 30-min infusion of ouabain into the round window niche. Anatomic examination showed a progressive ablation of ANFs following increasing concentration of ouabain. CAP amplitude and threshold plotted against loss of ANFs revealed three ANF pools: 1 ) a highly ouabain-sensitive pool, which does not participate in either CAP threshold or amplitude, 2 ) a less sensitive pool, which only encoded CAP amplitude, and 3 ) a ouabain-resistant pool, required for CAP threshold and amplitude. Remarkably, distribution of the three pools was similar to the SR-based ANF distribution (low-, medium-, and high-SR fibers), suggesting that the low-SR fiber loss leaves the CAP unaffected. Single-unit recordings from the auditory nerve confirmed this hypothesis and further showed that it is due to the delayed and broad first spike latency distribution of low-SR fibers. In addition to unraveling the neural mechanisms that encode CAP, our computational simulation of an assembly of guinea pig ANFs generalizes and extends our experimental findings to different species of mammals. Altogether, our data demonstrate that substantial ANF loss can coexist with normal hearing threshold and even unchanged CAP amplitude. auditory nerve fibers compound action potential computational modeling first spike latency ouabain Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords Auditory nerve fibers compound action potential computational modeling first spike latency Ouabain Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Contribution of auditory nerve fibers to compound action potential of the auditory nerve Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Contribution of auditory nerve fibers to compound action potential of the auditory nerve Jérôme Bourien , Yong Tang , Charlène Batrel , Antoine Huet , Marc Lenoir , Sabine Ladrech , Gilles Desmadryl , Régis Nouvian , Jean-Luc Puel , Jing Wang Journal of Neurophysiology Sep 2014, 112 (5) 1025-1039; DOI: 10.1152/jn.00738.2013 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Contribution of auditory nerve fibers to compound action potential of the auditory nerve Jérôme Bourien , Yong Tang , Charlène Batrel , Antoine Huet , Marc Lenoir , Sabine Ladrech , Gilles Desmadryl , Régis Nouvian , Jean-Luc Puel , Jing Wang Journal of Neurophysiology Sep 2014, 112 (5) 1025-1039; DOI: 10.1152/jn.00738.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat Microstimulation of the lumbar DRG recruits primary afferent neurons in localized regions of lower limb Dissociating vestibular and somatosensory contributions to spatial orientation Show more Sensory Processing Related Articles Web of Science Scopus PubMed Google Scholar Cited By... Auditory Brainstem Response Latency in Noise as a Marker of Cochlear Synaptopathy Abstract Fulltext PDF Aging after Noise Exposure: Acceleration of Cochlear Synaptopathy in "Recovered" Ears Abstract Fulltext PDF Web of Science (13) Scopus (14) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Natalia Dounskaia, Wanyue Wang

doi: 10.1152/jn.00082.2014pmid: 24872537

Abstract Redundancy of degrees of freedom (DOFs) during natural human movements is a central problem of motor control research. This study tests a novel interpretation that during arm movements, the DOF redundancy is used to support a preferred, simplified joint control pattern that consists of rotating either the shoulder or elbow actively and the other (trailing) joint predominantly passively by interaction and gravitational torques. We previously revealed the preference for this control pattern during nonredundant horizontal arm movements. Here, we studied whether this preference persists during movements with redundant DOFs and the redundancy is used to enlarge the range of directions in which this control pattern can be utilized. A free-stroke drawing task was performed that involved production of series of horizontal center-out strokes in randomly selected directions. Two conditions were used, with the arm's joints unconstrained (U) and constrained (C) to the horizontal plane. In both conditions, directional preferences were revealed and the simplified control pattern was used in the preferred and not in nonpreferred directions. The directional preferences were weaker and the range of preferred directions was wider in the U condition, with higher percentage of strokes performed with the simplified control pattern. This advantage was related to the usage of additional DOFs. We discuss that the simplified pattern may represent a feedforward control strategy that reduces the challenge of joint coordination caused by signal-dependent noise during movement execution. The results suggest a possibility that the simplified pattern is used during the majority of natural, seemingly complex arm movements. 3D arm movements optimal control interaction torque multijoint coordination neural control of movements Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords 3D arm movements optimal control interaction torque multijoint coordination neural control of movements Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following A preferred pattern of joint coordination during arm movements with redundant degrees of freedom Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools A preferred pattern of joint coordination during arm movements with redundant degrees of freedom Natalia Dounskaia , Wanyue Wang Journal of Neurophysiology Sep 2014, 112 (5) 1040-1053; DOI: 10.1152/jn.00082.2014 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share A preferred pattern of joint coordination during arm movements with redundant degrees of freedom Natalia Dounskaia , Wanyue Wang Journal of Neurophysiology Sep 2014, 112 (5) 1040-1053; DOI: 10.1152/jn.00082.2014 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section A sodium afterdepolarization in rat superior colliculus neurons and its contribution to population activity Regionally distinct cutaneous afferent populations contribute to reflex modulation evoked by stimulation of the tibial nerve during walking LRP predicts smooth pursuit eye movement onset during the ocular tracking of self-generated movements Show more Control of Movement Related Articles Web of Science Scopus PubMed Google Scholar Cited By... No citing articles found. Web of Science (4) Scopus (4) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... 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Krishnan Padmanabhan, Nathaniel N. Urban

doi: 10.1152/jn.00823.2013pmid: 24899672

Abstract Recent interest has emerged on the role of intrinsic biophysical diversity in neuronal coding. An important question in neurophysiology is understanding which voltage-gated ion channels are responsible for this diversity and how variable expression or activity of one class of ion channels across neurons of a single type affects they way populations carry information. In mitral cells in the olfactory bulb of mice, we found that biophysical diversity was conferred in part by 4-aminopyridine (4-AP)-sensitive potassium channels and reduced following block of those channels. When populations of mitral cells were stimulated with identical inputs, the diversity exhibited in their output spike patterns reduced with the addition of 4-AP, decreasing the stimulus information carried by ensembles of 15 neurons from 437 ± 15 to 397 ± 19 bits/s. Decreases in information were due to reduction in the diversity of population spike patterns generated in response to different features of the stimulus, suggesting that the coding capacity of a population can be altered by changes in the function of single ion channel types. biophysics coding diversity K v potassium channel olfaction Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords biophysics coding diversity Kv potassium channel olfaction Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Disrupting information coding via block of 4-AP-sensitive potassium channels Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Disrupting information coding via block of 4-AP-sensitive potassium channels Krishnan Padmanabhan , Nathaniel N. Urban Journal of Neurophysiology Sep 2014, 112 (5) 1054-1066; DOI: 10.1152/jn.00823.2013 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Disrupting information coding via block of 4-AP-sensitive potassium channels Krishnan Padmanabhan , Nathaniel N. Urban Journal of Neurophysiology Sep 2014, 112 (5) 1054-1066; DOI: 10.1152/jn.00823.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons Nitric oxide/cGMP/PKG signaling pathway activated by M 1 -type muscarinic acetylcholine receptor cascade inhibits Na + -activated K + currents in Kenyon cells Show more Cellular and Molecular Properties of Neurons Related Articles Web of Science Scopus PubMed Google Scholar Cited By... Diverse Representations of Olfactory Information in Centrifugal Feedback Projections Abstract Fulltext PDF Postnatal development attunes olfactory bulb mitral cells to high-frequency signaling Abstract Fulltext PDF Diverse cortical codes for scene segmentation in primate auditory cortex Abstract Fulltext PDF Web of Science (6) Scopus (4) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Anders S. Johansson, J. Andrew Pruszynski, Benoni B. Edin, Karl-Gunnar Westberg

doi: 10.1152/jn.00133.2014pmid: 24899675

Abstract Reflex responses in jaw-opening muscles can be evoked when a brittle object cracks between the teeth and suddenly unloads the jaw. We hypothesized that this reflex response is flexible and, as such, is modulated according to the instructed goal of biting through an object. Study participants performed two different biting tasks when holding a peanut half stacked on a chocolate piece between their incisors. In one task, they were asked to split the peanut half only (single-split task), and in the other task, they were asked to split both the peanut and the chocolate in one action (double-split task). In both tasks, the peanut split evoked a jaw-opening muscle response, quantified from electromyogram (EMG) recordings of the digastric muscle in a window 20–60 ms following peanut split. Consistent with our hypothesis, we found that the jaw-opening muscle response in the single-split trials was about twice the size of the jaw-opening muscle response in the double-split trials. A linear model that predicted the jaw-opening muscle response on a single-trial basis indicated that task settings played a significant role in this modulation but also that the presplit digastric muscle activity contributed to the modulation. These findings demonstrate that, like reflex responses to mechanical perturbations in limb muscles, reflex responses in jaw muscles not only show gain-scaling but also are modulated by subject intent. EMG jaw-opening reflex motor control reflex modulation trigeminal Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords EMG jaw-opening reflex motor control reflex modulation trigeminal Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Biting intentions modulate digastric reflex responses to sudden unloading of the jaw Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Biting intentions modulate digastric reflex responses to sudden unloading of the jaw Anders S. Johansson , J. Andrew Pruszynski , Benoni B. Edin , Karl-Gunnar Westberg Journal of Neurophysiology Sep 2014, 112 (5) 1067-1073; DOI: 10.1152/jn.00133.2014 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Biting intentions modulate digastric reflex responses to sudden unloading of the jaw Anders S. Johansson , J. Andrew Pruszynski , Benoni B. Edin , Karl-Gunnar Westberg Journal of Neurophysiology Sep 2014, 112 (5) 1067-1073; DOI: 10.1152/jn.00133.2014 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section A sodium afterdepolarization in rat superior colliculus neurons and its contribution to population activity Regionally distinct cutaneous afferent populations contribute to reflex modulation evoked by stimulation of the tibial nerve during walking LRP predicts smooth pursuit eye movement onset during the ocular tracking of self-generated movements Show more Control of Movement Related Articles Web of Science Scopus PubMed Google Scholar Cited By... Goal-dependent modulation of the long-latency stretch response at the shoulder, elbow, and wrist Abstract Fulltext PDF Web of Science (1) Scopus (1) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

David Souto, Dirk Kerzel

doi: 10.1152/jn.00810.2013pmid: 24920026

Abstract Involuntary ocular tracking responses to background motion offer a window on the dynamics of motion computations. In contrast to spatial attention, we know little about the role of feature-based attention in determining this ocular response. To probe feature-based effects of background motion on involuntary eye movements, we presented human observers with a balanced background perturbation. Two clouds of dots moved in opposite vertical directions while observers tracked a target moving in horizontal direction. Additionally, they had to discriminate a change in the direction of motion (±10° from vertical) of one of the clouds. A vertical ocular following response occurred in response to the motion of the attended cloud. When motion selection was based on motion direction and color of the dots, the peak velocity of the tracking response was 30% of the tracking response elicited in a single task with only one direction of background motion. In two other experiments, we tested the effect of the perturbation when motion selection was based on color, by having motion direction vary unpredictably, or on motion direction alone. Although the gain of pursuit in the horizontal direction was significantly reduced in all experiments, indicating a trade-off between perceptual and oculomotor tasks, ocular responses to perturbations were only observed when selection was based on both motion direction and color. It appears that selection by motion direction can only be effective for driving ocular tracking when the relevant elements can be segregated before motion onset. smooth pursuit eye movements feature-based attention attention motion eye movements Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords smooth pursuit eye movements feature-based attention attention motion eye movements Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Your Personal Message Print Citation Tools Ocular tracking responses to background motion gated by feature-based attention David Souto , Dirk Kerzel Journal of Neurophysiology Sep 2014, 112 (5) 1074-1081; DOI: 10.1152/jn.00810.2013 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Ocular tracking responses to background motion gated by feature-based attention David Souto , Dirk Kerzel Journal of Neurophysiology Sep 2014, 112 (5) 1074-1081; DOI: 10.1152/jn.00810.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat Microstimulation of the lumbar DRG recruits primary afferent neurons in localized regions of lower limb Dissociating vestibular and somatosensory contributions to spatial orientation Show more Sensory Processing Related Articles Web of Science PubMed Google Scholar Cited By... No citing articles found. Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Isabelle Bareither, Maximilien Chaumon, Fosco Bernasconi, Arno Villringer, Niko A. Busch

doi: 10.1152/jn.00550.2013pmid: 24872526

Abstract The cerebral cortex responds to stimuli of a wide range of intensities. Previous studies have demonstrated that undetectably weak somatosensory stimuli cause a functional deactivation or inhibition in somatosensory cortex. In the present study, we tested whether invisible visual stimuli lead to similar responses, indicated by an increase in EEG alpha-band power—an index of cortical excitability. We presented subliminal and supraliminal visual stimuli after estimating each participant's detection threshold. Stimuli consisted of peripherally presented small circular patches that differed in their contrast to a background consisting of a random white noise pattern. We demonstrate that subliminal and supraliminal stimuli each elicit specific neuronal response patterns. Supraliminal stimuli evoked an early, strongly phase-locked lower-frequency response representing the evoked potential and induced a decrease in alpha-band power from 400 ms on. By contrast, subliminal visual stimuli induced an increase of non-phase-locked power around 300 ms that was maximal within the alpha-band. This response might be due to an inhibitory mechanism, which reduces spurious visual activation that is unlikely to result from external stimuli. alpha-band EEG event-related synchronization oscillations subthreshold stimulation Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords alpha-band EEG event-related synchronization oscillations subthreshold stimulation Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Invisible visual stimuli elicit increases in alpha-band power Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Invisible visual stimuli elicit increases in alpha-band power Isabelle Bareither , Maximilien Chaumon , Fosco Bernasconi , Arno Villringer , Niko A. Busch Journal of Neurophysiology Sep 2014, 112 (5) 1082-1090; DOI: 10.1152/jn.00550.2013 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Invisible visual stimuli elicit increases in alpha-band power Isabelle Bareither , Maximilien Chaumon , Fosco Bernasconi , Arno Villringer , Niko A. Busch Journal of Neurophysiology Sep 2014, 112 (5) 1082-1090; DOI: 10.1152/jn.00550.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat Microstimulation of the lumbar DRG recruits primary afferent neurons in localized regions of lower limb Dissociating vestibular and somatosensory contributions to spatial orientation Show more Sensory Processing Related Articles Web of Science Scopus PubMed Google Scholar Cited By... Ongoing Alpha Activity in V1 Regulates Visually Driven Spiking Responses Abstract Fulltext PDF Imperceptible Somatosensory Stimulation Alters Sensorimotor Background Rhythm and Connectivity Abstract Fulltext PDF Decreased visual detection during subliminal stimulation Abstract Fulltext PDF Web of Science (2) Scopus (2) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... 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Christopher T. Frenz, Anne Hansen, Nicholas D. Dupuis, Nicole Shultz, Simon R. Levinson, Thomas E. Finger, Vincent E. Dionne

doi: 10.1152/jn.00154.2014pmid: 24872539

Abstract Olfactory sensory neurons (OSNs) fire spontaneously as well as in response to odor; both forms of firing are physiologically important. We studied voltage-gated Na + channels in OSNs to assess their role in spontaneous activity. Whole cell patch-clamp recordings from OSNs demonstrated both tetrodotoxin-sensitive and tetrodotoxin-resistant components of Na + current. RT-PCR showed mRNAs for five of the nine different Na + channel α-subunits in olfactory tissue; only one was tetrodotoxin resistant, the so-called cardiac subtype Na V 1.5. Immunohistochemical analysis indicated that Na V 1.5 is present in the apical knob of OSN dendrites but not in the axon. The Na V 1.5 channels in OSNs exhibited two important features: 1 ) a half-inactivation potential near −100 mV, well below the resting potential, and 2 ) a window current centered near the resting potential. The negative half-inactivation potential renders most Na V 1.5 channels in OSNs inactivated at the resting potential, while the window current indicates that the minor fraction of noninactivated Na V 1.5 channels have a small probability of opening spontaneously at the resting potential. When the tetrodotoxin-sensitive Na + channels were blocked by nanomolar tetrodotoxin at the resting potential, spontaneous firing was suppressed as expected. Furthermore, selectively blocking Na V 1.5 channels with Zn 2+ in the absence of tetrodotoxin also suppressed spontaneous firing, indicating that Na V 1.5 channels are required for spontaneous activity despite resting inactivation. We propose that window currents produced by noninactivated Na V 1.5 channels are one source of the generator potentials that trigger spontaneous firing, while the upstroke and propagation of action potentials in OSNs are borne by the tetrodotoxin-sensitive Na + channel subtypes. Na V 1.5 sodium channels window currents spontaneous firing olfactory sensory neurons olfaction Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords NaV1.5 sodium channels window currents spontaneous firing olfactory sensory neurons olfaction Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following NaV1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Na V 1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons Christopher T. Frenz , Anne Hansen , Nicholas D. Dupuis , Nicole Shultz , Simon R. Levinson , Thomas E. Finger , Vincent E. Dionne Journal of Neurophysiology Sep 2014, 112 (5) 1091-1104; DOI: 10.1152/jn.00154.2014 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Na V 1.5 sodium channel window currents contribute to spontaneous firing in olfactory sensory neurons Christopher T. Frenz , Anne Hansen , Nicholas D. Dupuis , Nicole Shultz , Simon R. Levinson , Thomas E. Finger , Vincent E. Dionne Journal of Neurophysiology Sep 2014, 112 (5) 1091-1104; DOI: 10.1152/jn.00154.2014 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons Nitric oxide/cGMP/PKG signaling pathway activated by M 1 -type muscarinic acetylcholine receptor cascade inhibits Na + -activated K + currents in Kenyon cells Show more Cellular and Molecular Properties of Neurons Related Articles Web of Science PubMed Google Scholar Cited By... No citing articles found. Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Idan Blank, Nancy Kanwisher, Evelina Fedorenko

doi: 10.1152/jn.00884.2013pmid: 24872535

Abstract What is the relationship between language and other high-level cognitive functions? Neuroimaging studies have begun to illuminate this question, revealing that some brain regions are quite selectively engaged during language processing, whereas other “multiple-demand” (MD) regions are broadly engaged by diverse cognitive tasks. Nonetheless, the functional dissociation between the language and MD systems remains controversial. Here, we tackle this question with a synergistic combination of functional MRI methods: we first define candidate language-specific and MD regions in each subject individually (using functional localizers) and then measure blood oxygen level-dependent signal fluctuations in these regions during two naturalistic conditions (“rest” and story-comprehension). In both conditions, signal fluctuations strongly correlate among language regions as well as among MD regions, but correlations across systems are weak or negative. Moreover, data-driven clustering analyses based on these inter-region correlations consistently recover two clusters corresponding to the language and MD systems. Thus although each system forms an internally integrated whole, the two systems dissociate sharply from each other. This independent recruitment of the language and MD systems during cognitive processing is consistent with the hypothesis that these two systems support distinct cognitive functions. functional connectivity language multiple demand system Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords functional connectivity language multiple demand system Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following A functional dissociation between language and multiple-demand systems revealed in patterns of BOLD signal fluctuations Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools A functional dissociation between language and multiple-demand systems revealed in patterns of BOLD signal fluctuations Idan Blank , Nancy Kanwisher , Evelina Fedorenko Journal of Neurophysiology Sep 2014, 112 (5) 1105-1118; DOI: 10.1152/jn.00884.2013 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share A functional dissociation between language and multiple-demand systems revealed in patterns of BOLD signal fluctuations Idan Blank , Nancy Kanwisher , Evelina Fedorenko Journal of Neurophysiology Sep 2014, 112 (5) 1105-1118; DOI: 10.1152/jn.00884.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Altered intrinsic connectivity of the auditory cortex in congenital amusia Novel method for functional brain imaging in awake minimally restrained rats The involvement of model-based but not model-free learning signals during observational reward learning in the absence of choice Show more Higher Neural Functions and Behavior Related Articles Web of Science Scopus PubMed Google Scholar Cited By... The modular and integrative functional architecture of the human brain Abstract Fulltext PDF Web of Science (7) Scopus (8) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Yudan Liu, Meghan Harding, Andrea Pittman, Jules Dore, Jörg Striessnig, Anjali Rajadhyaksha, Xihua Chen

doi: 10.1152/jn.00757.2013pmid: 24848473

Abstract Dopaminergic projections from the ventral tegmental area (VTA) constitute the mesolimbocortical system that underlies addiction and psychosis primarily as a result of increased dopaminergic transmission. Dopamine release is spike dependent. L-type calcium channels (LTCCs) play an important role in regulating firing activities, but the contribution of specific subtypes remains unclear. This article describes different functions of Ca v 1.2 and Ca v 1.3 subtypes in regulating firing properties with two transgenic mouse strains. For basal firing, Ca v 1.3-deficient (Ca v 1.3 −/− ) mice had a lower basal firing frequency. The dihydropyridine (DHP) channel blocker nifedipine reduced single-spike firing in mice expressing DHP-insensitive Ca v 1.2 channels (Ca v 1.2DHP −/− mice), confirming the significant contribution from the Ca v 1.3 subtype in basal firing. Moreover, the DHP channel activator ( S )-(−)-Bay K8644 and the non-DHP channel activator FPL 64176 converted firing patterns from single spiking to bursting in Ca v 1.2DHP −/− mice. Nifedipine inhibited burst firing induced by both activators, suggesting that Ca v 1.3 also serves an essential role in burst firing. However, FPL 64176 also induced bursting in Ca v 1.3 −/− mice. These results indicate that the Ca v 1.3 subtype is crucial to regulation of basal single-spike firing, while activation of both Ca v 1.2 and Ca v 1.3 can support burst firing of VTA neurons. action potential firing patterns calcium channel transgenic mouse patch-clamp recording Copyright © 2014 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords action potential firing patterns calcium channel transgenic mouse patch-clamp recording Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Cav1.2 and Cav1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Ca v 1.2 and Ca v 1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area Yudan Liu , Meghan Harding , Andrea Pittman , Jules Dore , Jörg Striessnig , Anjali Rajadhyaksha , Xihua Chen Journal of Neurophysiology Sep 2014, 112 (5) 1119-1130; DOI: 10.1152/jn.00757.2013 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Ca v 1.2 and Ca v 1.3 L-type calcium channels regulate dopaminergic firing activity in the mouse ventral tegmental area Yudan Liu , Meghan Harding , Andrea Pittman , Jules Dore , Jörg Striessnig , Anjali Rajadhyaksha , Xihua Chen Journal of Neurophysiology Sep 2014, 112 (5) 1119-1130; DOI: 10.1152/jn.00757.2013 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons Nitric oxide/cGMP/PKG signaling pathway activated by M 1 -type muscarinic acetylcholine receptor cascade inhibits Na + -activated K + currents in Kenyon cells Show more Cellular and Molecular Properties of Neurons Related Articles Web of Science Scopus PubMed Google Scholar Cited By... Ion Homeostasis in Rhythmogenesis: The Interplay Between Neurons and Astroglia Abstract Fulltext PDF Web of Science (8) Scopus (8) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598