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doi: 10.1084/jem.8.1.8pmid: 19867033
The facts collected in the third part of this paper justify the following conclusions: (1) All of the cardinal symptoms of Stokes-Adams disease may be duplicated by heart-block resulting from a lesion in or near the auriculo-ventricular bundle of His, and by this alone. (2) No typical case of Stokes-Adams disease has been described in which heart-block might not have been the cause of the trouble. (3) It can be shown that all cases of Stokes-Adams disease which have been studied by sufficiently accurate methods were cases of heart-block. (4) It would appear that heart-block without and with syncopal attacks are two stages of the same disease process.
doi: 10.1084/jem.8.1.64pmid: 19867031
The reparative process which follows the wide spread necrosis of the dog's liver caused by the injection of hæmagglutinative serum constitutes a chronic interstitial hepatitis of definite and constant character. This is not only a new type of experimental hepatic lesion, but is more definitely a cirrhosis than is any other experimental lesion hitherto described. It is of importance in explaining the histogenesis of cirrhosis, and incidentally various repair processes in the liver; but it does not aid in the elucidation of the etiology of cirrhosis in man, nor does it explain the peculiar arrangement of the new connective tissue in any form of human cirrhosis except possibly that associated with chronic passive congestion. It definitely demonstrates, however, that cirrhosis may follow extensive primary destructive lesions, a view not yet fully accepted, and supports the contention of Kretz that cirrhosis is essentially a reparative process.
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