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doi: 10.2165/00003495-200666070-00003pmid: 16740006
When treating diabetic foot ulcers it is important to be aware of the natural history of the diabetic foot, which can be divided into five stages: stage 1, a normal foot; stage 2, a high risk foot; stage 3, an ulcerated foot; stage 4, an infected foot; and stage 5, a necrotic foot. This covers the entire spectrum of foot disease but emphasises the development of the foot ulcer as a pivotal event in stage 3, which demands urgent and aggressive management. Diabetic foot care in all stages needs multidisciplinary management to control mechanical, wound, microbiological, vascular, metabolic and educational aspects. Achieving good metabolic control of blood glucose, lipids and blood pressure is important in each stage, as is education to teach proper foot care appropriate for each stage.
Robinson, Dean; Keating, Gillian
doi: 10.2165/00003495-200666070-00007pmid: 16740010
▲ A new formulation of paclitaxel, 130-nanometre albumin-bound paclitaxel (nab™ -paclitaxel), solubilises hydrophobic paclitaxel and may increase paclitaxel delivery to tumour cells.
McKeage, Kate; Croom, Katherine
doi: 10.2165/00003495-200666070-00011pmid: 16740014
▴ Decitabine is a hypomethylating agent. Its action in DNA leads to the reactivation of tumour suppressor genes and the subsequent differentiation of cancer cells.
McCormack, Paul; Keating, Gillian
doi: 10.2165/00003495-200666070-00014pmid: 16740017
▴ Delapril/manidipine 30mg/10mg is a new oral, once-daily, fixed combination of an ACE inhibitor and a dihydropyridine calcium-channel antagonist for the treatment of essential hypertension.
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