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Brockbank, John; Gladman, Dafna
doi: 10.2165/00003495-200262170-00004pmid: 12421102
Psoriatic arthritis (PsA) is considered to be one of the spondyloarthritides, and as such has both spinal and peripheral joint involvement. In 80% of patients, psoriasis usually precedes the development of arthritis.
Bygdeman, Marc; Danielsson, Kristina
doi: 10.2165/00003495-200262170-00005pmid: 12421103
Vacuum aspiration, either manual or electric, has for many years been the most commonly used method for termination of an early pregnancy. More recently, new medical methods have been developed which for many women are attractive alternatives to the surgical procedure. The compounds mainly used are prostaglandin analogues, methotrexate, and mifepristone in combination with a suitable prostaglandin analogue. However, only the last method has been registered for routine clinical use. The treatment schedule mainly used is mifepristone 200 to 600mg followed 36 to 48 hours later by oral misoprostol 0.4 to 0.6mg in pregnancies up to 49 days and vaginal gemeprost 1.0mg or misoprostol 0.8mg if the treatment period is extended to 63 days of amenorrhoea.
Culy, Christine; Keating, Gillian
doi: 10.2165/00003495-200262170-00013pmid: 12421111
Psoriatic Arthritis: Subcutaneous etanercept 25mg twice weekly significantly reduced arthritic disease activity and improved skin lesions in patients with psoriatic arthritis in two placebo-controlled trials of 12 and 24 weeks’ duration. Clinical response in these studies was measured according to two standard criteria: ACR criteria and the psoriatic arthritis response criteria (PsARC). Changes in psoriasis activity were also assessed in patients with plaque psoriasis involvement over ≥3% of their body surface area.
doi: 10.2165/00003495-200262170-00002pmid: 12421100
During the reproductive period, women generally have lower low-density lipoprotein (LDL) cholesterol and higher high-density lipoprotein cholesterol than age- and diet-matched men. However, these possibly antiatherogenic characteristics of lipoproteins are changed to a potentially atherogenic profile after menopause. Menopause-related changes in lipoprotein profile can be corrected by the administration of hormone replacement therapy (HRT). However, the results of recent studies did not show definite benefits of HRT on coronary heart disease-related mortality rates. On the other hand, several large-scale, long-term clinical trials provide evidence for efficacy and safety of HMG-CoA reductase inhibitors (statins) in both men and women. The results of 19 short-term clinical trials using simvastatin, pravastatin, fluvastatin or lovastatin in postmenopausal women are summarised and discussed. All these investigations reported significant reductions in both total and LDL cholesterol levels. The question of whether statin therapy results in a significant decrease in cardiovascular-related mortality rates along with a better quality of life in postmenopausal women remains to be investigated in large-scale, randomised, double-blind, placebo-controlled clinical trials.
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