Drugs

Finder, R.; Brogden, R.; Speight, T.; Avery, G.

doi: 10.2165/00003495-197713060-00001pmid: 324751

Viloxazine1, 2-(2-ethoxyphenoxymethyl)-2,3,5,6-tetrahydro-1, 4-oxazine, is structurally distinct from conventional tri- or tetra-cyclic antidepressants. In contrast to imipramine, it has minimal sedative anticholinergic or adrenergic effects in man; it acts in part like an amphetamine-type central stimulant though there is little evidence of dependence or non-durability of drug effects. Viloxazine is indicated for use in the treatment of all types of depression, and may be especially useful in the elderly if they have no history of proneness to nausea or if they have a tendency to delirium.

Cole, Peter

doi: 10.2165/00003495-197713060-00002pmid: 16738

There are four basic mechanisms by which allergic reactions to drugs occur: (I) immediate hypersensitivity in which drug as antigen combines with IgE antibody attached to receptors on mast cells in the respiratory tract or on circulating leucocytes; (2) cytotoxic reactions in which complement causes cell membrane rupture by becoming ‘fixed’ during a reaction between antidrug antibody and drug antigen attached to the cell membrane; (3) immune-complex mediated hypersensitivity where soluble drug antigen-antibody complexes are formed when the drug antigen is present in excess; and (4) delayed hypersensitivity in which thymus-derived (T-) lymphocytes become sensitised to a drug and cause tissue-damaging cytotoxic reactions when the drug is subsequently administered.

Holdaway, M.

doi: 10.2165/00003495-197713060-00004pmid: 862529

Fieve, Ronald

doi: 10.2165/00003495-197713060-00005pmid: 862530

Restiaux, N.

doi: 10.2165/00003495-197713060-00006pmid: 862531

Eadie, M.; Wade, D.; Ardagh, J.; Cridland, Marion; Holmes, C.; Cass, Noel; Robinson, R.

doi: 10.2165/00003495-197713060-00007pmid: N/A