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doi: 10.2165/00003495-199346060-00003pmid: 7510613
Calcium antagonists block calcium entry into cells, resulting in relaxation of smooth muscle and limitation of the cytotoxic effects of ischaemia in various organ systems. They are most frequently used for clinical conditions requiring vasodilatation, i.e. hypertension and Raynaud’s phenomenon, and this also suggests that the most common adverse effect of these drugs for noncardiovascular indications is an unwanted decline in blood pressure.
doi: 10.2165/00003495-199346060-00004pmid: 7510614
Ranitidine has been used for the treatment of millions of patients during the past 10 years. A small proportion of patients have developed a reaction to the drug shortly after the start of treatment, usually as a result of ‘individual idiosyncrasy’. Reactions during continuous, long term treatment with ranitidine are uncommon, so that maintenance treatment of the chronic peptic diseases with ranitidine for more than 10 years has not been associated with significant iatrogenic disease.
Saggar-Malik, Anand; Cappuccio, Francesco
doi: 10.2165/00003495-199346060-00005pmid: 7510615
Epidemiological and clinical studies suggest that low dietary potassium intake may have an important role in determining the development of diseases such as hypertension, and perhaps even stomach cancer, and that increased potassium intake may have beneficial effects in several other conditions Dietary adjustment or active potassium supplementation has been suggested as a natural less costly and safe method of increasing potassium levels, although active supplementation with tablets or solutions is not recommended in healthy people with normal serum potassium levels. However, increasing dietary potassium intake in the elderly and in patients with renal impairment must be considered with caution.
Kälviäinen, Reetta; Keränen, Tapani; Riekkinen, Paavo
doi: 10.2165/00003495-199346060-00006pmid: 7510609
There are several new antiepileptic drugs undergoing extensive clinical investigation. Five new drugs — vigabatrin, lamotrigine, gabapentin, felbamate and oxcarbazepine — appear to be the most widely tested and promising agents.
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