Diabetologia

Fang, C.; Dong, F.; Ren, B.; Epstein, P.; Ren, J.

doi: 10.1007/s00125-005-1940-ypmid: 16172869

These data indicate that oxidative stress may play an important role in cardiac contractile dysfunction associated with glucose intolerance and possibly related to alteration in insulin signalling at the receptor and post-receptor levels.

Kobayashi, Y.; Naruse, K.; Hamada, Y.; Nakashima, E.; Kato, K.; Akiyama, N.; Kamiya, H.; Watarai, A.; Nakae, M.; Oiso, Y.; Nakamura, J.

doi: 10.1007/s00125-005-1942-9pmid: 16195866

These observations suggest that C-peptide could prevent diabetic macroangiopathy by inhibiting smooth muscle cell growth and ameliorating glucose utilisation in smooth muscle cells. C-peptide may thus be a novel agent for treating diabetic macroangiopathy in patients with type 1 and type 2 diabetes.

Dunstan, D.; Salmon, J.; Owen, N.; Armstrong, T.; Zimmet, P.; Welborn, T.; Cameron, A.; Dwyer, T.; Jolley, D.; Shaw, J.

doi: 10.1007/s00125-005-1963-4pmid: 16211373

Increased TV viewing time was associated with an increased prevalence of the metabolic syndrome, while physical activity was associated with a reduced prevalence. Population strategies addressing the metabolic syndrome should focus on reducing sedentary behaviours such as TV viewing, as well as increasing physical activity.

Löfgren, P.; Hoffstedt, J.; Näslund, E.; Wirén, M.; Arner, P.

doi: 10.1007/s00125-005-1961-6pmid: 16222518

Body-weight-reduced obese women had low basal and catecholamine-stimulated adipocyte lipolysis, presumably due to adipose tissue hyperplasia. This could make an important contribution to body weight gain following weight loss. Adipocyte insulin resistance is secondary to obesity.

Arner, P.

doi: 10.1007/s00125-005-1956-3pmid: 16193286

Gao, R.; Ustinov, J.; Korsgren, O.; Otonkoski, T.

doi: 10.1007/s00125-005-1935-8pmid: 16193291

These results suggest that islet neogenesis in this culture system at least partly represents the de-differentiation of islet cells into a duct-cell-like phenotype, with further re-differentiation in appropriate conditions. The plasticity of differentiated human pancreatic cell types may thus be an important mechanism of human pancreas regeneration.

Weickert, M.; Mohlig, M.; Koebnick, C.; Holst, J.; Namsolleck, P.; Ristow, M.; Osterhoff, M.; Rochlitz, H.; Rudovich, N.; Spranger, J.; Pfeiffer, A.

doi: 10.1007/s00125-005-1941-xpmid: 16172868

Riggs, A.; Bernal-Mizrachi, E.; Ohsugi, M.; Wasson, J.; Fatrai, S.; Welling, C.; Murray, J.; Schmidt, R.; Herrera, P.; Permutt, M.

doi: 10.1007/s00125-005-1947-4pmid: 16215705

Hutchinson, D.; Chernogubova, E.; Dallner, O.; Cannon, B.; Bengtsson, T.

doi: 10.1007/s00125-005-1936-7pmid: 16160864

These results suggest a pathway where increases in cAMP mediated by β-adrenoceptors leads to activation of AMPK in brown adipocytes, which contributes in part to β-adrenoceptor-mediated increases in glucose uptake, an effect independent of the presence or function of UCP1.

Atkinson, M.; Rhodes, C.

doi: 10.1007/s00125-005-1957-2pmid: 16193285