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The recent approval in the US and Europe of imatinib (Gleevac™) for patients with bcr/abl-positive chronic myelogenous leukemia and the considerable public interest in new anticancer drugs that take advantage of specific genetic defects that render the malignant cells more likely to respond to...
There are a number of ways in which surgery, radiation therapy, and more recently chemotherapy have been employed in the treatment of locally advanced cervical cancer. The evidence in favor of chemoradiation in cervical cancer was summarized in a meta-analysis of 19 trials which showed...
The most potent angiogenic cytokine is vascular endothelial growth factor (VEGF). A number of strategies have been developed to inhibit the activity of the VEGF molecule and its receptors. These strategies include gene therapy techniques that deliver antisense oligonucleotides, soluble VEGF...
Pain is a common symptom in patients with cancer, and requires careful assessment and appropriate therapy in order to improve quality of life. Treatment for pain requires modification in the presence of renal disease.
Fulvestrant (Faslodex®) is a novel estrogen receptor (ER) antagonist that competitively binds to the ER with a much greater affinity than that of tamoxifen. The downregulation of cellular levels of the ER protein results in complete abrogation of estrogen-sensitive gene transcription. This...
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