journal article
LitStream Collection
Home
Lee, Amie Y.; Raz, Dan J.; He, Biao; Jablons, David M.
doi: 10.1002/cncr.22552pmid: 17348013
Malignant mesothelioma (MM) is a highly aggressive tumor with a very poor prognosis. The disease is largely unresponsive to conventional chemotherapy or radiotherapy, and most patients die within 10–17 months of the first symptoms. Novel, more effective therapeutic strategies are needed for this inexorably fatal disease. Improvement in our understanding of the molecular biology of MM has identified promising new candidates for targeted treatments. In this review the key molecular signaling pathways, including vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), Wnt, and the cell cycle control genes p53, pRb, and bcl‐2 that appear to play an important role in the pathogenesis of MM are explored. Cancer 2007. © 2007 American Cancer Society.
Lutz, Stephen T.; Chow, Edward L.; Hartsell, William F.; Konski, Andre A.
doi: 10.1002/cncr.22555pmid: 17330854
Radiotherapy commonly is employed to address symptoms in patients with symptoms caused by cancer. For this article, the authors reviewed data supporting the use of hypofractionated palliative radiotherapy. In addition to single‐fraction treatment for painful bony metastasis, the available literature suggested that courses of 2 to 14 external‐beam fractions may provide equivalent relief to longer course treatment in patients with a poor prognosis who have primary cancers of the lung, rectum, bladder, prostate, head and neck, spleen, and gynecologic system. Hypofractionated treatment delivers palliation that is time efficient, cost effective, and minimally toxic. Evidence suggests that the reluctance of radiation oncologists to provide single‐fraction treatment acts as a barrier to referrals from palliative care professionals. Collaboration in education, research, and patient advocacy will advance the common objectives of the 2 specialties and lead to an appropriate increase in the use of palliative hypofractionated radiotherapy. Cancer 2007. © 2007 American Cancer Society.
Zhang, Jun; Jia, Zhiliang; Li, Qiang; Wang, Liwei; Rashid, Asif; Zhu, Zhenggang; Evans, Douglas B.; Vauthey, Jean‐Nicolas; Xie, Keping; Yao, James C.
doi: 10.1002/cncr.22554pmid: 17340592
Lee, W. Robert; Bae, Kyoungwha; Lawton, Colleen; Gillin, Michael; Morton, Gerard; Firat, Selim; Baikadi, Madhava; Kuettel, Michael; Greven, Kathryn; Sandler, Howard
doi: 10.1002/cncr.22560pmid: 17340591
Showing 1 to 10 of 31 Articles