doi: 10.1093/labmed/20.9.605pmid: N/A
Article PDF first page preview Close This content is only available as a PDF. © American Society of Clinical Pathologists
doi: 10.1093/labmed/20.9.609pmid: N/A
Article PDF first page preview Close This content is only available as a PDF. © American Society of Clinical Pathologists
Mammen, Eberhard, F.;Fujii,, Yukihiko
doi: 10.1093/labmed/20.9.611pmid: N/A
Abstract In the last few years it has become apparent that certain alterations in the coagulation system predispose to thromboembolic diseases. Increased clotting or decreased fibrinolysis can be associated with such hypercoagulable states. Increased clotting is found in patients with major deficiencies in the regulators of the system. Antithrombin III, protein C, protein S, and heparin cofactor 11 abnormalities are associated with increased intravascular fibrin formation. These disorders may be congenital and are usually autosomal dominant. In most cases thrombosis is triggered by an outside event, such as trauma, surgery, or childbirth. Decreased fibrinolysis predisposing to thromboembolism is encountered in patients with plasminogen abnormalities, decreased tissue plasminogen activator release, or increased tissue plasminogen activator inhibitor levels. Some patients with factor XII or prekallikrein deficiencies also present with thrombosis. Both factors activate plasminogen intrinsically. The presence of a lupus anticoagulant or an anticardiolipin antibody also predisposes to thrombosis. These are acquired IgG or IgM antibodies directed against phospholipid moieties essential for the formation of clotting complexes. The mechanism by which they predispose to thrombosis is as yet uncertain. This content is only available as a PDF. © American Society of Clinical Pathologists
Podlasek, Stanley, J.;McPherson, Richard, A.
doi: 10.1093/labmed/20.9.617pmid: N/A
Abstract We report the case of a 67-year-old man who developed an autoantibody against lactate dehydrogenase (LD) in association with an episode of pericarditis following soon after myocardial infarction and streptokinase treatment. This anti-LD was shown to he an IgM antibody. The alteration in LD isoenzyme electrophoretic pattern caused by this IgM anti-LD was modified by treatment with dithiothreitol. The molecular size of the LD-antibody complex established by gel filtration was consistent with an LD-IgM interaction. This temporal association of an IgM anti-LD primary immune response after streptokinase infusion suggests that streptokinase may play an etiologic role in stimulating formation of anti-LD antibodies. This content is only available as a PDF. © American Society of Clinical Pathologists
Park, Choong, H.;Hixon, Deborah, L.;Cook, James, F.;Park, Tong, S.;Lyle, Janice, A.;Benedett, Coleen, T.
doi: 10.1093/labmed/20.9.620pmid: N/A
Abstract The efficacy of a new rapid (30-minute) latex agglutination test for group B streptococci (GBS) was compared with culture results using cervical, placental, and gastric aspirate specimens from 220 highrisk pregnant women and their infants. The overall colonization rate was 19.1%. Sensitivity, specificity, and positive and negative predictive values for any colonization in all specimens combined were 88.0%, 96.6%, 86.0%, and 97.2%, respectively, and were 97.4%, 96.4%, 86.0%, and 99.4%, respectively, for heavy colonization. This latex test is easy to perform and provides a rapid, cost-effective, and reliable method for detection of heavy GBS colonization in high-risk patients. This content is only available as a PDF. © American Society of Clinical Pathologists
Cramer, Adelbert, D.;Chogyoji,, Marilyn;Saxena,, Sunita;Appleman, Maria, D.;Wong, Edward, T.
doi: 10.1093/labmed/20.9.623pmid: N/A
Abstract The effectiveness of a macroscopic screening urinalysis, consisting of an assessment of turbidity and testing with a multiparameter dipstick, was evaluated as a basis for deciding whether to examine the urine sediment microscopically. The population studied consisted of 1,385 specimens collected over a 9-day sampling period that included inpatients and outpatients at a large municipal hospital. When the screening macroscopic urinalysis is negative, the microscopic examination of the sediment produces an extremely low yield and maybe omitted. The macroscopic screening urinalysis allows the labor-intensive microscopic examination of the urine sediment to be used selectively without adversely affecting patient care. This content is only available as a PDF. © American Society of Clinical Pathologists
Sarkozi,, Laszlo;Jacobs,, Ellis
doi: 10.1093/labmed/20.9.628pmid: N/A
Abstract Between 1965 and 1985, the Consumer Price Index for medical items increased 4.5 times in the United States. During the same 20 years, at our institution's chemistry laboratories, the productivity (reported as number of tests/technologist/year) increased from 14,000 to 73,500. When expressed in constant 1965 dollars, salary per test was reduced from $0.60 to $0.13, supplies cost per test from $0.09 to $0.06, and the total cost per test from $0.69 to $0.19. This content is only available as a PDF. © American Society of Clinical Pathologists
doi: 10.1093/labmed/20.9.632pmid: N/A
Abstract Data from a cross-sectional mail and telephone survey of medical laboratory technician (MLT) and medical technology (MT) graduates from Massachusetts colleges offering associate-degree MLT and/or baccalaureate MT programs were used to examine professional standing and to assess marital status and the presence of dependents as determinants of labor-force participation and professional retention. Employment among women MTs but not MLTs was related to marital status. Women's labor-force participation at both occupational levels was influenced by the presence of dependents. Among working graduates, retention in medical technology-related careers was associated with sex but not marital status or the presence of dependents. While employment and retention are high, 30% of these recent MLT and MT graduates are not in clinical laboratory practice. This content is only available as a PDF. © American Society of Clinical Pathologists
Sheridan,, Don;Kischer, C., Ward;Pindur,, Jana
doi: 10.1093/labmed/20.9.637pmid: N/A
Abstract A hand-made cutting device consisting of stainless steel razor blades separated by plastic shims provides macrosections of unfixed or fixed tissues with uniform thickness. The number of blades and the thickness of the shims may be varied. This content is only available as a PDF. © American Society of Clinical Pathologists
Blansit, Bryant, Douglas;Lobel, Steven, A.
doi: 10.1093/labmed/20.9.639pmid: N/A
Article PDF first page preview Close This content is only available as a PDF. © American Society of Clinical Pathologists
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