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doi: 10.1111/j.1365-2133.1979.tb03565.xpmid: 427010
SUMMARYThe dermatosis described over 40 years ago by Sulzberger and Garbe is still being seen and is still without known cause, aetiology or pathogenetic mechanism. Its kaleidoscopic changes in clinical appearance cause it to mimic many other dermatoses. But in typical cases it can be recognized by an assemblage of clinical and histopathological characteristics and distinguished from other known dermatoses. Modern techniques may shed light upon its causal mechanism and either establish it as an entity or place it in nosological perspective.
doi: 10.1111/j.1365-2133.1979.tb03566.xpmid: 371654
SUMMARYThe lethal intestino‐cutaneous syndrome which we described in 1942 as malignant atrophic papulosis (MAP) has gained various other visceral sites. However, the cutaneous eruption remains the constant and pathognomonic symptom, which, despite its benign appearance harbours a serious prognosis because of the frequently very severe lesions in the small intestine, and sometimes of the nervous system.The very special histological structure shows zones of necrosis (dermal in the skin) due to vasculitis with a tendency to thrombosis, affecting the small vessels below the lesion, and with little or no inflammatory reaction, which differentiates it from other angiitis.The aetiology remains uncertain (?viral) and the treatment is disappointing although heparin appears to have been helpful occasionally.
doi: 10.1111/j.1365-2133.1979.tb03567.xpmid: 427011
SUMMARYThe first publication identifying acrodermatitis enteropathica as a definite disease (Danbolt & Gloss, 1942) is reviewed. Later studies are briefly surveyed, resulting in the recognition of the disease as a zinc deficiency which can be effectively corrected by administration of small oral doses of zinc.
doi: 10.1111/j.1365-2133.1979.tb03569.xpmid: 371656
SUMMARYPapular acrodermatitis of childhood (PAC), first recognized in Milan and described by Gianotti in 1955, is an infectious disease of childhood, of low infectivity, fairly widespread, and characterized by:1Non‐relapsing erythemato‐papular dermatitis localized to the face and limbs, lasting about 3 weeks.2Paracortical hyperplasia of lymph‐nodes.3Acute hepatitis, usually anicteric, which lasts at least 2 months and may progress to chronic liver disease.4Hepatitis B surface antigenaemia, subtype ayw, which may persist for a long time.PAC must be differentiated from other frequent papular or papulo‐vesicular acro‐located eruptions of unknown origin, which should be classified as ‘Papulo‐vesicular acro‐located syndrome’ until their aetiology is clarified.
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