journal article
LitStream Collection
Production of vitamin B12 by microorganisms and its occurrence in plant tissues
2008 The Botanical Review
doi: 10.1007/BF02861845pmid: N/A
During the four years which have passed since the microbiological fermentation of vitamin B12 complex was first accomplished, major developments have occurred, and the production of vitamin B12 and its various complexes has become a major fermentation industry with substantial markets in human and animal nutrition. Factors which have contributed to the highly successful developmental work on the production of this vitamin include the isolation of cultures, the selection of media, a study of the optimum conditions of temperature, aeration and agitation necessary for largescale fermentation, and the establishment of suitable recovery processes for the fermentation broths. The natural occurrence of this vitamin appears to be attributable to microorganisms and algae instead of higher plants or animals.