Unusual presentation of herpes simplex virus infection in a boxer: ‘Boxing glove herpes’García‐García, Begoña; Galache‐Osuna, Cristina; Coto‐Segura, Pablo; Suárez‐Casado, Héctor; Mallo‐García, Susana; Jiménez, Jorge Santos‐Juanes
doi: 10.1111/j.1440-0960.2011.00815.xpmid: 23373892
ABSTRACT Herein, we describe a patient with lesions of cutaneous herpes simplex virus 1 (HSV‐1) infection over the knuckles of both hands in the context of an outbreak among boxers. Interestingly, the infection had an unusually long duration (4 weeks), and was not acquired directly through skin‐to‐skin contact, as it usually does among athletes (herpes gladiatorum). In our case, transmission was acquired through the use of shared boxing gloves contaminated by HSV‐1. To the best of our knowledge, herpes gladiatorum, or wrestler's herpes, has not been described previously in boxers and infection over the knuckles is not commonly reported.
Granuloma annulare‐like reaction to the bacillus Calmette‐Guerin vaccinationNomiyama, Tomoko; Takenaka, Hideya; Kishimoto, Saburo; Katoh, Norito
doi: 10.1111/j.1440-0960.2011.00814.xpmid: 23373894
ABSTRACT We report the case of a 6‐month‐old girl with a granuloma annulare (GA)‐like reaction to the bacillus Calmette‐Guerin (BCG) vaccination. The eruption developed at the vaccination site 1 month after vaccination and the lesion gradually disseminated over the body within 2 months. A biopsy specimen of the skin lesion showed degenerated collagen bundles surrounded by imperfect palisading histiocytes, lymphocytes and epithelioid cells in the dermis, which led to a diagnosis of GA‐like reaction as a secondary reaction to BCG inoculation. The eruption at the vaccination site and the scattered GA reaction resolved after 1 month of treatment with prednisolone valerate acetate ointment, leaving only pigmentation.
Oral erosive lichen planus associated with thymoma treated with etretinateMiyagaki, Tomomitsu; Sugaya, Makoto; Miyamoto, Akie; Nagata, Mayumi; Ichimura, Yohei; Mitsui, Hiroshi; Sato, Shinichi
doi: 10.1111/j.1440-0960.2011.00818.xpmid: 23373893
ABSTRACT A 68‐year‐old Japanese woman was referred to our hospital with a 1‐year history of multiple erosions on the oral mucosa and a few pruritic, bean‐sized, reddish‐blue plaques on the body. Based on physical examination, pathological findings, and immunofluorescence findings, a diagnosis of lichen planus (LP) was made. Computed tomography scan revealed a thymoma. After thymectomy, cutaneous LP lesions subsided spontaneously. Oral lesions responded well to oral etretinate therapy. We speculate that direct tissue injury by CD8+ T cells, activated by abnormal regulation of lymphocytes within the thymus, may cause LP.
A case of pityriasis rubra pilaris associated with membranous nephropathyLin, Chin‐Yun; Maurice, Paul DL; Cross, Nick B
doi: 10.1111/j.1440-0960.2011.00807.xpmid: 23373888
ABSTRACT Pityriasis rubra pilaris (PRP) is a rare idiopathic dermatosis which may be associated with autoimmune diseases, HIV infection, and internal malignancies. Its association with renal diseases is, however, much less recognized. We report a case of PRP with associated membranous nephropathy (MN), which resolved spontaneously with resolution of the dermatosis. This is only the second reported association between PRP and MN of which we are aware. Further reports of such an association will strengthen the evidence for the two conditions being linked and may thereby shed light on the pathogenesis of both PRP and MN.
Primary localized cutaneous nodular amyloidosis successfully treated with cyclophosphamideTong, Philip L; Walker, William A; Glancy, Ross J; Cooney, Julian P; Gebauer, Kurt
doi: 10.1111/j.1440-0960.2011.00770.xpmid: 23373889
ABSTRACT Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare subtype of localized cutaneous amyloidosis and can be associated with various connective tissue disorders. It can be difficult to treat and past therapies include surgical excision, dermabrasion, electrodessication and curettage, cryotherapy and laser therapy. We present a case of a middle‐aged woman with PLCNA associated with CREST (calcinosis, Raynaud phenomenon, oesophageal motility disorders, sclerodactyly and telangiectasia) syndrome and Sjögren's syndrome responding to cyclophosphamide with no new amyloid deposits and resolution of skin ulceration after many years of resistance to drug therapy. It is important to monitor these patients for progression into systemic amyloidosis.
Discoid lupus erythematosus at a site of previous injuryRuocco, Eleonora; Brunetti, Giampiero; Sangiuliano, Sonia; Caccavale, Stefano; Lo Schiavo, Ada
doi: 10.1111/j.1440-0960.2011.00786.xpmid: 23373890
ABSTRACT A 71‐year‐old man with three patches of discoid lupus erythematosus (DLE) confined to the right preauricular region drew our attention because of the unusual linear arrangement of the lesions. Twenty‐five years previously, the patient had suffered a trauma in the same area from falling off his motorcycle. We believe that, despite the great lapse in time, this injury may have facilitated the onset of DLE in the very same area, through long‐term destabilization of the local neuroimmune network. The case fits the recently coined concept of the immunocompromised district, a cutaneous region with altered immune control, more susceptible to harbouring opportunistic infections, tumours, and immune disorders.
High throughput investigative dermatology in 2012 and beyond: A new era beckonsGilmore, Stephen J
doi: 10.1111/j.1440-0960.2012.00883.xpmid: 22506776
ABSTRACT High throughput molecular biology began around the mid‐1990s with the introduction of microarrays – a technology that enabled investigators to quantify the cellular expression levels of tens of thousands of mRNA transcripts simultaneously. To date, a large number of microarray experiments have been performed in the investigation of RNA expression signatures in normal and pathological tissues. This review focuses on a next generation tool in high throughput investigation: RNA sequencing or RNA‐Seq, highlighting its advantages over traditional microarray investigation and discussing its utility in investigative dermatology. In contrast with the results obtained from microarray experiments, RNA‐Seq generates mRNA abundance counts, can identify novel transcripts and splice variants, and provides sequence resolution at the level of single base‐pairs. Implementing RNA‐Seq in the investigation of skin disease will yield novel insights into the pathogenesis of disease, will facilitate the discovery of new diseases and new mechanisms of disease, and will allow researchers to probe genetic disease in high resolution and with unprecedented efficiency.
Extramammary Paget's disease of the vulva: An annotated review of the current literatureDelport, Elsie Sophia
doi: 10.1111/j.1440-0960.2012.00898.xpmid: 22671146
ABSTRACT Extramammary Paget's disease is a rare and unusual neoplastic entity that presents mainly on apocrine gland‐bearing skin. The vulva is the most common site of involvement but any area of the anogenital skin can be affected. Due to its rarity, variable clinical course and deceptive histological appearance it has a high misdiagnosis rate and both gynaecologists and dermatologists have limited experience in its management. The significance of the disease lies in its association with underlying malignancy as well as its inherent ability to invade the dermis and metastasise. The management is notoriously complicated and recurrence rates are high despite aggressive surgeries. Several alternative modalities are being explored, with results that are often variable and unpredictable. This review summarises the histopathological, clinical and therapeutic features of extramammary Paget's disease of the vulva reported in recent years.