doi: 10.1080/00032718008077693pmid: N/A
Abstract This is a scanned image of the original Editorial Board page(s) for this issue.
Puttemans, F.; Vernaillen, M.; Massart, D. L.
doi: 10.1080/00032718008077694pmid: N/A
Abstract By using densitometry the method of Gutzeit, previously considered to be a semiquantitative method, attains a quantitative character. The entire method, digestion of the biological materials included, is characterised by a coefficient of variation of 14%. This procedure appears to be well suited for the determination of normal values of arsenic in urine.
Tanizawa, K.; Hirasawa, T.; Soda, K.
doi: 10.1080/00032718008077695pmid: N/A
Abstract Simple and sensitive colorimetric procedures for the measurement of several nitroalkanes have been developed. The methods are based on the oxidative denitrification of nitroalkanes by nitroalkane oxidase and the spectrophotometric determination of one of the reaction products: nitrite, carbonyl compounds and hydrogen peroxide. A linear relationship has been established between the absorbance of the colored products and the amount of nitroalkanes (0.01 – 0.1 μmol).
Balya, Dennis R.; Farrah, George H.
doi: 10.1080/00032718008077696pmid: N/A
Abstract Certain oils cause considerable interference in the determination of PCBs by gas chromatography with electron capture detection, requiring time-consuming sample clean-up procedures. Column chromatography, using small, radially-compressed silica columns, is used to isolate PCBs in various oil matrices, thus permitting quantitative analysis. Pure mineral oil, phosphate ester, glycol-base, and sulfonated mineral oils were studied.
doi: 10.1080/00032718008077697pmid: N/A
Abstract The raicroscale liquid chromatographic tecnnique was applied to gel perraination chromatography. As the results, the miniaturized GPC column requires smaller amounts of sample, packing materials and carrier solvent than those required with the ordinary GPC column, and it would be applicable to preparatory experiments to select the operation conditions for fractionation by GPC.
Garbagna, L.; Cojazzi, M.; Mussini, E.
doi: 10.1080/00032718008077698pmid: N/A
Abstract A very sensitive analytical technique is described for measuring phosphodiesterase (PDE) activity in mouse muscle, where levels of these enzymes are very low. After the action of PDE, a second enzyme, 5′nucleotidase, is employed to release inorganic phosphorus (Pi) which is assayed by a colorimetric method using malachite-green as dye solution. It is thus possible to measure very small amounts of Pi (0.1 – 0.5 μg) and to assay PDE activity with all the cyclic nucleotides even in the presence of methyl-xanthines. Phosphodiesterase assay in this manner gives a response that is linear with serial amounts of purified enzyme and different quantities of muscle homogenate.
Hoogewijs, Guido; Matterne, Johan; Massart, Desire L.
doi: 10.1080/00032718008077699pmid: N/A
Abstract Reversed-phase liquid chromatographic systems using a solid stationary phase (C, Q) have been studied in order to separate the most common pyrazolone derivatives. The possibilities of improving the separation by ion-pair formation have been investigated using 1-heptanesulfonate, octylsulfate and dioctylsulfosuc-cinate as ion-pairing anions and cetrimide as ion-pairing cation. It is shown that the retention of the ion-pairs is increased with increasing counterionconcentration only up to a certain limit not ionized molecules are decreasing with increasing counterion From thereon the capacity factors of both ion-pairs and not ionized molecules are decreasing with increasing counterionconcentration, probably due to adsorption of counterions to the stationary phase.
doi: 10.1080/00032718008077700pmid: N/A
Abstract A normal-phase HPLC system using a microparticulate silica column and a modified butyl chloride mobile phase was applied to the determination of acetaminophen in various dosage forms. The method is accurate, precise, stability-indicating and takes less than 30 minutes for most samples. Sample preparation consists of dissolving the drug from the matrix and dilution to an appropriate volume.
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