American Journal of Psychiatry

Schubert, H; Fleischhacker, WW; Meise, U; Theohar, C

doi: N/Apmid: 6148895

Ten patients experiencing sudden opiate withdrawal received low doses of guanfacine. Improvement was noticeable within the first 4 days and was most evident in moderate to severe cases. The major effect was on autonomic

CHESTER SCHMIDT

doi: N/Apmid: N/A

Stern, SL; Dixon, KN; Nemzer, E; Lake, MD; Sansone, RA; Smeltzer, DJ; Lantz, S; Schrier, SS

doi: N/Apmid: 6592984

The authors determined the lifetime prevalence of affective disorder in the first- and second-degree relatives, excluding children, of 27 bulimic women who had never had anorexia nervosa and 27 women with no history of an eating disorder. Family diagnoses were made blind to the proband's diagnosis. The prevalence of affective disorder was 9% in the relatives of the bulimic probands and 10% in the relatives of the control probands, a nonsignificant difference. These findings are in contrast to reports of an increased prevalence of affective disorder in the relatives of patients

Liu, SJ; Wang, RI

doi: N/Apmid: 6486271

A methadone maintenance patient with a decreased plasma methadone level, possibly due to phenobarbital-induced acceleration of methadone biotransformation, experienced opioid withdrawal symptoms. This finding suggests that when phenobarbital is used with methadone the plasma

Rasmussen, SA

doi: N/Apmid: 6435460

Obsessive-compulsive patients with symptoms resistant to clomipramine were treated by lithium or L-tryptophan augmentation. The improvement noted supports the hypothesis that increasing serotonergic neurotransmission

D Ramchandani

doi: N/Apmid: N/A

Stoudemire, A; Miller, J; Schmitt, F; Logue, P; Shelton, D; Latson, G; Bennett, P

doi: N/Apmid: 6435458

The authors describe the clinical and pharmacologic management of a patient who developed an organic affective syndrome during a simulated deep-diving experiment. The physiological complexities of deep-diving research are reviewed, as well as the neuropsychiatric symptoms of the high pressure

HOWARD A. WINKLER

doi: N/Apmid: N/A

JK Witschy, GL Malone, and LD Holden

doi: N/Apmid: N/A

Price, LH; Charney, DS; Heninger, GR

doi: N/Apmid: 6091464

Three patients experienced yohimbine-induced manic symptoms. The authors discuss a possible neurobiological mechanism for this reaction to