Journal of American Geriatrics Society

Sykes, Marguerite P.; Salem, Philip; Joffe, Bernard

doi: 10.1111/j.1532-5415.1971.tb02216.xpmid: 5153692

Topical 5‐fluorouracil (ointment) is an effective, inexpensive and safe remedy for solar and actinic keratoses. This form of therapy also seems to be indicated for patients with multiple and recurrent epitheliomas that have not responded well to surgery and/or x‐ray therapy. It is important to keep in mind the occasional variability in the effective dosage and the rare occurrence of a prolonged disfiguring reaction to treatment.

Haunz, E. A.; Cornatzer, W. E.; Luper, Miltza; Baldwin, Jerry J.

doi: 10.1111/j.1532-5415.1971.tb02217.xpmid: 5153693

Serum LDH isoenzyme fractions were evaluated in non‐diabetic control subjects, diet‐controlled diabetic patients and diabetic patients receiving chlorpropamide (Diabinese) in addition to diet. Statistically significant elevations of fraction I were observed in both the diet‐controlled and the chlorpropamide diet‐controlled diabetic groups when compared with the normal controls. Fraction III, however, showed a statistically significant decrease in activity in the two diabetic groups when compared with the normal controls. No significant changes were observed in the other fractions. The findings indicate that the diabetic state per se may elicit an increase in fraction I with a decrease in fraction III, and that chlorpropamide therapy has no effect on the relative concentrations of the various serum LDH isoenzymes. This evidence confirms a previous observation from this laboratory that liver function remains unaltered during chlorpropamide therapy and that the mild abnormalities reported here are in all likelihood peculiar to the diabetic state itself.

Pollitt, Jorge; Lee, Bak Moo

doi: 10.1111/j.1532-5415.1971.tb02218.xpmid: 5153694

The author reports a case of renal failure due to atheroembolism precipitated by translumbar aortography. When the abdominal aorta contains atheromatous plaques, there is great danger of producing showers of atheroemboli by this procedure.

Buckman, Gerald F.

doi: 10.1111/j.1532-5415.1971.tb02219.xpmid: 5153695

More attention should be paid to communication disorders in the geriatric population. Appropriate areas of referral to speech and hearing pathologists include aphasia and apraxia (so common after stroke), various dysarthrias (e.g., in parkinsonism), the requirements for esophageal artificial speech after laryngectomy, and presbycusis. Interdisciplinary cooperation will lead to complete rehabilitation services for all patients.

Cheraskin, E.; Ringsdorf, W. M.

doi: 10.1111/j.1532-5415.1971.tb02220.xpmid: 5153688

With a lamelleted sphere as a model, an analysis of the periphery of the human subject (symptoms and signs) is useful in providing a measure of the extent of disease. However, in itself, it has little utility in a predictive medicine program. In present multiple‐testing methods, correlation of the biochemical state with the symptoms and signs is the basis for making a diagnosis of classical disease. However, the predictive potential is limited. A predictive medicine program, to fulfill its true purpose, must view the total sphere in all its layers.

Kiveloff, Broino; Huber, Olive

doi: 10.1111/j.1532-5415.1971.tb02221.xpmid: 5153689

Brief, maximal isometric exercise of six seconds' duration, repeated three times daily for five to eight weeks may be associated with lowering of the blood pressure in hypertensive patients. In 8 subjects with hypertension there was a decrease of 16–42 mm Hg in systolic pressure and 2–24 mm in diastolic pressure. In 5 subjects receiving a constant dosage of hypotensive drugs, there was a decrease of 4–28 mm in systolic pressure and 2–14 mm in diastolic pressure. In 2 subjects previously treated with hypotensive drugs in whom isometric exercise was substituted for the drugs, normal blood pressure was maintained for eleven months.

Terplan, Martin

doi: 10.1111/j.1532-5415.1971.tb02222.xpmid: 5153690

Despite severe arterial insufficiency (with claudication) in both lower extremities, insertion of a cardiac pacemaker improved the distal circulation in a 76‐year‐old man with atrioventricular dissociation. This result suggests that when the cardiac condition requires insertion of a pacemaker, this procedure should antedate any arterial reconstruction in cases of severe peripheral vascular disease.

Case, Thomas C.

doi: 10.1111/j.1532-5415.1971.tb02223.xpmid: 5153691

doi: 10.1111/j.1532-5415.1971.tb02224.xpmid: N/A

doi: 10.1111/j.1532-5415.1971.tb02225.xpmid: N/A