Angewandte Chemie International Edition

Horne, W. Seth; Olsen, Christian A.; Beierle, John M.; Montero, Ana; Ghadiri, M. Reza

doi: 10.1002/anie.200805900pmid: 19267380

Fooling enzymes with mock amides: Analogues of apicidin, a cyclic‐tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4‐ or 1,5‐disubstituted 1,2,3‐triazole in place of a backbone amide bond to fix the bond in question in either a trans‐like or a cis‐like configuration. Thus, the binding affinity of distinct peptide conformations (see picture) could be probed. One analogue proved in some cases to be superior to apicidin as an HDAC inhibitor.

Beierle, John M.; Horne, W. Seth; van Maarseveen, Jan H.; Waser, Beatrice; Reubi, Jean Claude; Ghadiri, M. Reza

doi: 10.1002/anie.200805901pmid: 19266506

A would‐be amide: A 1,4‐disubstituted 1,2,3‐triazole was used as a surrogate for a trans amide bond to create a library of 16 diastereomeric pseudotetrapeptides as β‐turn mimetics. High‐resolution structural analysis indicated that these scaffolds adopt distinct, rigid, conformationally homogeneous β‐turn‐like structures (see example), some of which bind somatostatin receptor subtypes selectively, and some of which show broad‐spectrum activity.

Cao, Dapeng; Lan, Jianhui; Wang, Wenchuan; Smit, Berend

doi: 10.1002/anie.200900960pmid: 19466727

Quick on the uptake: A multiscale theoretical method predicts that the gravimetric adsorption capacities of H2 in Li‐doped covalent organic frameworks based on the building blocks shown (Li violet, H white, B pink, C green, O red, Si yellow) can reach nearly 7 % at T=298 K and p=100 bar, suggesting that these Li‐doped materials are promising adsorbents for hydrogen storage.

Schöffel, Julia; Rogachev, Andrey Yu.; DeBeer George, Serena; Burger, Peter

doi: 10.1002/anie.200901494pmid: 19466728

An N for Ir: The synthesis and X‐ray crystal structure of a late‐transition‐metal complex with a terminal nitrido ligand and its hydrogenation to the related amido complex are reported (see scheme).

Tsuruoka, Takaaki; Furukawa, Shuhei; Takashima, Yohei; Yoshida, Kaname; Isoda, Seiji; Kitagawa, Susumu

doi: 10.1002/anie.200901177pmid: 19472244

A growing attachment: Porous coordination polymer (PCP) nanorods are synthesized by modulation of the coordination equilibria between framework components, which regulates the rate of framework extension and crystal growth. Investigation of the crystal growth mechanism by TEM indicates that face‐selective modulation on the surfaces of PCP crystals enhances the anisotropic crystal growth of nanorods by an oriented attachment mechanism.

Wang, Naiwei; Matsumoto, Tsutomu; Ueno, Masaharu; Miyamura, Hiroyuki; Kobayashi, Shū

doi: 10.1002/anie.200900565pmid: 19466725

Golden capillaries: A gold‐immobilized capillary column reactor allows oxidation of alcohols to carbonyl compounds using molecular oxygen. These capillary columns (see picture) can be used for at least four days without loss of activity.

Zhang, Wei; Jin, Wusong; Fukushima, Takanori; Ishii, Noriyuki; Aida, Takuzo

doi: 10.1002/anie.200900756pmid: 19472240

The assembly line: Hexabenzocoronene amphiphiles appended with pyridyl‐terminated triethylene glycol side chains, in combination with trans‐(Pt(PhCN)2Cl2), lead to the formation of graphitic nanotubes. The structural features and dimensions of the nanotubes depend on the assembly conditions. A platinum(II)‐bridged cyclic dimer having two HBC units self‐assembles into a nanotubular structure.

Wu, Bohua; Hu, Dan; Kuang, Yinjie; Liu, Bo; Zhang, Xiaohua; Chen, Jinhua

doi: 10.1002/anie.200900899pmid: 19452506

Small beginnings: Metal nanoparticle/CNT nanohybrids are synthesized from carbon nanotubes (CNTs) functionalized with an ionic‐liquid polymer. The Pt and PtRu nanoparticles with narrow size distribution (average diameter: (1.3±0.4) nm for PtRu, (1.9±0.5) nm for Pt) are dispersed uniformly on the CNTs (see images) and show good performance in methanol electrooxidation.

Jiang, Zhong‐Xing; Liu, Xin; Jeong, Eun‐Kee; Yu, Yihua Bruce

doi: 10.1002/anie.200901005pmid: 19475598

Getting FIT: A bispherical 19F imaging tracer, 19FIT, was designed and synthesized. 19FIT is advantageous over perfluorocarbon‐based 19F imaging agents, as it is not retained in the organs and does not require complex formulation procedures. Imaging agents such as 19FIT can lead to 19F magnetic resonance imaging (MRI) playing an important role in drug therapy, analogous to the role played by 1H MRI in disease diagnosis.

Liu, Song; Li, Jianming; Shen, Qian; Cao, Yang; Guo, Xuefeng; Zhang, Guoming; Feng, Chaoqun; Zhang, Jin; Liu, Zhongfan; Steigerwald, Michael L.; Xu, Dongsheng; Nuckolls, Colin

doi: 10.1002/anie.200901018