Psychiatric Disorders in the Families of Schizotypal SubjectsBattaglia,, Marco;Gasperini,, Mariangela;Sciuto,, Gabriella;Scherillo,, Patrizia;Diaferia,, Gluseppina;Bellodi,, Laura
doi: 10.1093/schbul/17.4.659pmid: 1805355
Abstract In a study of the families of 21 schizotypal patients, we found an increased morbidity risk for schizophrenia compared with that in the families of 21 nonschizotypal patients and 42 controls. The Axis I diagnoses did not influence the distribution of the morbidity risk in the families of the schizotypal patients. If the schizotypal subjects also had other personality disorders, the morbidity risk for schizophrenia among their relatives was lower, although not significantly. This content is only available as a PDF. © Oxford University Press
Negative Association Between Schizophrenia and Rheumatoid ArthritisVinogradov, Sophia; Gottesman, Irving I.; Moises, Hans W.; Nicol, Susan
doi: N/Apmid: N/A
Persuasive evidence has accumulated demonstrating a strong negative association between rheumatoid arthritis and schizophrenia at the population level. Explanations for this phenomenon have taken into consideration immunological, biochemical, and genetic factors. In this article, we examine these and other factors in closer detail. We then propose hypotheses at the molecular level that might account for the negative association between the two diseases. These hypotheses may provide clues for our colleagues in molecular biology as they search for candidate genes, “anti-genes,” and molecular mechanisms relevant to schizophrenia.
Negative Association Between Schizophrenia and Rheumatoid ArthritisVinogradov,, Sophia;Gottesman, Irving, I.;Moises, Hans, W.;Nicol,, Susan
doi: 10.1093/schbul/17.4.669pmid: 1805356
Abstract Persuasive evidence has accumulated demonstrating a strong negative association between rheumatoid arthritis and schizophrenia at the population level. Explanations for this phenomenon have taken into consideration immunological, biochemical, and genetic factors. In this article, we examine these and other factors in closer detail. We then propose hypotheses at the molecular level that might account for the negative association between the two diseases. These hypotheses may provide clues for our colleagues in molecular biology as they search for candidate genes, “anti-genes,” and molecular mechanisms relevant to schizophrenia. This content is only available as a PDF. © Oxford University Press
Two Types of Thought Disorder and Lateralized Neuropsychological DysfunctionSilverstein, Marshall L.; Marengo, Joanne T.; Fogg, Louis
doi: N/Apmid: N/A
This report examined positive and negative thought disorder in relation to medication status and cerebral lateralization measures obtained from the Halstead-Reitan Neuropsychological Battery and Wechsler Adult Intelligence Scale in a sample of 59 patients with schizophrenia, schizoaffective and manic disorders, and unspecified functional psychoses. Discriminant function analyses of comparable left- and right-hemisphere variables from the neuropsychological tests were examined for both types of thought disorder, in which presence or absence of psychotropic medications was included as a variable in each analysis. Results indicated a relationship between positive thought disorder and left- but not right-hemisphere variables. Both the left- and right-hemisphere variables were related to negative thought disorder, and these relationships were influenced by the global measures of verbal and performance IQ as well as by medication status. These findings provide qualified support for the left-hemisphere-dysfunction hypothesis, insofar as it is associated specifically with positive thought disorder. Diffuse or bilateral cerebral impairment is more characteristic of negative thought disorder; however, medication status is also equivalent to neuropsychological variables in influencing this relationship.
Two Types of Thought Disorder and Lateralized Neuropsychological DysfunctionSilverstein, Marshall L.; Marengo, Joanne T.; Fogg, Louis
doi: 10.1093/schbul/17.4.679pmid: 1805357
This report examined positive and negative thought disorder in relation to medication status and cerebral lateralization measures obtained from the Halstead-Reitan Neuropsychological Battery and Wechsler Adult Intelligence Scale in a sample of 59 patients with schizophrenia, schizoaffective and manic disorders, and unspecified functional psychoses. Discriminant function analyses of comparable left- and right-hemisphere variables from the neuropsychological tests were examined for both types of thought disorder, in which presence or absence of psychotropic medications was included as a variable in each analysis. Results indicated a relationship between positive thought disorder and left- but not right-hemisphere variables. Both the left- and right-hemisphere variables were related to negative thought disorder, and these relationships were influenced by the global measures of verbal and performance IQ as well as by medication status. These findings provide qualified support for the left-hemisphere-dysfunction hypothesis, insofar as it is associated specifically with positive thought disorder. Diffuse or bilateral cerebral impairment is more characteristic of negative thought disorder; however, medication status is also equivalent to neuropsychological variables in influencing this relationship.
Two Types of Thought Disorder and Lateralized Neuropsychological DysfunctionSilverstein, Marshall, L.;Marengo, Joanne, T.;Fogg,, Louis
doi: 10.1093/schbul/17.4.679pmid: 1805357
Abstract This report examined positive and negative thought disorder in relation to medication status and cerebral lateralization measures obtained from the Halstead-Reitan Neuropsychological Battery and Wechsler Adult Intelligence Scale in a sample of 59 patients with schizophrenia, schizoaffective and manic disorders, and unspecified functional psychoses. Discriminant function analyses of comparable left- and right-hemisphere variables from the neuropsychological tests were examined for both types of thought disorder, in which presence or absence of psychotropic medications was included as a variable in each analysis. Results indicated a relationship between positive thought disorder and left- but not right-hemisphere variables. Both the left- and right-hemisphere variables were related to negative thought disorder, and these relationships were influenced by the global measures of verbal and performance IQ as well as by medication status. These findings provide qualified support for the left-hemisphere-dysfunction hypothesis, insofar as it is associated specifically with positive thought disorder. Diffuse or bilateral cerebral impairment is more characteristic of negative thought disorder; however, medication status is also equivalent to neuropsychological variables in influencing this relationship. This content is only available as a PDF. © Oxford University Press
First Person Account: Living With SchizophreniaSmith,, Evelyn
doi: 10.1093/schbul/17.4.689pmid: 1805358
Abstract The article that follows is part of the Schizophrenia Bulletin's ongoing First Person Accounts series. We hope that mental health professionals—the Bulletin's primary audience—will take this opportunity to learn about the issues and difficulties confronted by consumers of mental health care. In addition, we hope that these accounts will give patients and families a better sense of not being alone in confronting the problems that can be anticipated by persons with serious emotional difficulties. We welcome other contributions from patients, ex-patients, or family members. Our major editorial requirement is that such contributions be clearly written and organized, and that a novel or unique aspect of schizophrenia be described, with special emphasis on points that will be important for professionals. Clinicians who see articulate patients, with experiences they believe should be shared, might encourage these patients to submit their articles to First Person Accounts, Division of Clinical Research, Schizophrenia Research Branch, NIMH, 5600 Fishers Lane, Rm. 10C-16, Rockville, MD 20857.—The Editors. This content is only available as a PDF. © Oxford University Press