Clinical and Experimental Dermatology

Yip, Alphonsus; Roy, Nandini; Natkunarajah, Janakan

doi: 10.1093/ced/llaf128pmid: 40080679

To our knowledge, we report the first known case of neural trophic syndrome localized to the thoracic region, which we propose to term ‘thoracic trophic syndrome’. An 89-year-old woman presented with a persistent ulcerative wound on her chest, associated with radiation therapy from 30 years prior and worsened by chronic scratching. This case expands the spectrum of neural trophic syndromes beyond trigeminal and cervical locations, underscoring the need for diagnostic awareness in similar presentations.

Affleck, Andrew

doi: 10.1093/ced/llaf069pmid: 39918083

A personal account of a patient having formalin-fixed slow Mohs of a scalp dermatofibrosarcoma protuberans is given. The impact on her life is highlighted.

Li, Grace X; Sebaratnam, Deshan F

doi: 10.1093/ced/llaf008pmid: 39775837

A 5.5-month-old male, exclusively breastfed and born prematurely at 26 weeks, presented with a progressive facial and scrotal rash, unresponsive to general skin care, topical mupirocin and corticosteroids. On examination, the facial rash was well-demarcated and papulosquamous with a periorificial distribution. The scrotal rash was well-demarcated and erythematous with a conspicuous hyperpigmented margin.

Fleming, Sarah; Carthy, Kieran; Granahan, Aoife; Byrne, Berbie; Andrawis, Madonna; Drumm, Claire; Rafferty, Siobhan; Salim, Asad

doi: 10.1093/ced/llaf108pmid: 40071670

A healthy female patient presented with a rapidly evolving lesion on her left posterior arm. Of note, she had a significant history of sunbed exposure.

Weng, Pei-Chun; Chen, Kuang-Hua; Lin, Chien-Yio

doi: 10.1093/ced/llaf044pmid: 39918045

Cutaneous metastases account for 1–10% of all metastases. Carcinoma en cuirasse, a form of cutaneous metastasis, manifests with hardened and erythematous skin lesions and should be differentiated from other entities such as infection and dermatitis. Here, we present a case of metastatic breast cancer presenting as carcinoma en cuirasse, which was initially misdiagnosed as herpes zoster.

Ali, Omar M E; Haqiqi, Ala; Salem, Rana; Nasr, Batoul; Hampton, Philip

doi: 10.1093/ced/llaf039pmid: 39888350

We report the case of a 31-year-old Nigerian woman with a recurrent papulovesicular eruption. To the best of our knowledge, this represents one of the first known cases of this disease in skin of colour. We discuss the clinical and histopathological features, as well as relevant immunohistochemical markers.

Kan, Siyue; Yang, Lianjuan; Cai, Qing

doi: 10.1093/ced/llaf079pmid: 39980338

We report a woman with a 1-year history of asymptomatic and atrophic rash on her trunk. We describe the clinical presentation, mycological tests and histopathological examinations we performed to make a diagnosis.

Arora, Neha; Leszczynska, Maria; Preston, Allie; Furukawa, Betsy

doi: 10.1093/ced/llaf072pmid: 39920473

A 51-year-old man was evaluated for large plaques with numerous white to yellow firm papules on the bilateral posterior lower legs and abdomen along with multiple cream to yellow dermal papules on the toes. Past medical history included chronic gout with inconsistent medication adherence.

Yong, Ji Fung; Lai, Fei; Hackett, Caitriona; Tobin, Anne-Marie

doi: 10.1093/ced/llaf042pmid: 39880397

Itch, or pruritus, is a common and unpleasant sensation transmitted by both the peripheral and central nervous systems, sharing pathways with pain sensation. The itch pathway is complex, and itch is a perplexing symptom. We report a patient whose presentation following a spinal stroke highlights the potential mechanism of neuropathic itch, the challenges in managing chronic neuropathic itch and dysaesthesia and the importance of a holistic approach in treating patients who have these symptoms.

Gambichler, Thilo; Gencik, Martin; Schmidt, Jacqueline; Kekelyova, Patricia; Boms, Stefanie

doi: 10.1093/ced/llaf125pmid: 40257101

Netherton syndrome, including ichthyosis linearis circumflexa (ILC), is a very rare autosomal recessive disorder resulting from mutations in SPINK5, which encodes serine protease inhibitor Kazal-type 5 (SPINK5) [also known as lymphoepithelial Kazal-type-related inhibitor (LEKTI)]. Here, we report on a boy presenting with ILC and atopy but notably lacking hair shaft abnormalities, associated with novel frameshift variants in SPINK5.