Journal of Neurophysiology

Roger Cachope, Alberto E. Pereda

doi: 10.1152/jn.00165.2015pmid: 26019311

Abstract Opioid receptors were shown to modulate a variety of cellular processes in the vertebrate central nervous system, including synaptic transmission. While the effects of opioid receptors on chemically mediated transmission have been extensively investigated, little is known of their actions on gap junction-mediated electrical synapses. Here we report that pharmacological activation of mu-opioid receptors led to a long-term enhancement of electrical (and glutamatergic) transmission at identifiable mixed synapses on the goldfish Mauthner cells. The effect also required activation of both dopamine D1/5 receptors and postsynaptic cAMP-dependent protein kinase A, suggesting that opioid-evoked actions are mediated indirectly via the release of dopamine from varicosities known to be located in the vicinity of the synaptic contacts. Moreover, inhibitory inputs situated in the immediate vicinity of these excitatory synapses on the lateral dendrite of the Mauthner cell were not affected by activation of mu-opioid receptors, indicating that their actions are restricted to electrical and glutamatergic transmissions co-existing at mixed contacts. Thus, as their chemical counterparts, electrical synapses can be a target for the modulatory actions of the opioid system. Because gap junctions at these mixed synapses are formed by fish homologs of the neuronal connexin 36, which is widespread in mammalian brain, it is likely that this regulatory property applies to electrical synapses elsewhere as well. gap junction connexin 36 connexin 35 Mauthner cell dopamine auditory teleost Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords gap junction connexin 36 connexin 35 Mauthner cell dopamine auditory teleost Article Abstract MATERIAL AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Opioids potentiate electrical transmission at mixed synapses on the Mauthner cell Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Opioids potentiate electrical transmission at mixed synapses on the Mauthner cell Roger Cachope , Alberto E. Pereda Journal of Neurophysiology Jul 2015, 114 (1) 689-697; DOI: 10.1152/jn.00165.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Opioids potentiate electrical transmission at mixed synapses on the Mauthner cell Roger Cachope , Alberto E. Pereda Journal of Neurophysiology Jul 2015, 114 (1) 689-697; DOI: 10.1152/jn.00165.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons Nitric oxide/cGMP/PKG signaling pathway activated by M 1 -type muscarinic acetylcholine receptor cascade inhibits Na + -activated K + currents in Kenyon cells Show more Cellular and Molecular Properties of Neurons Related Articles Web of Science Scopus PubMed Google Scholar Cited By... No citing articles found. Web of Science (1) Scopus (2) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... 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C. R. Boychuk, K. Cs. Halmos, B. N. Smith

doi: 10.1152/jn.00209.2015pmid: 25995347

Abstract Autonomic dysregulation accompanies type-1 diabetes, and synaptic regulation of parasympathetic preganglionic motor neurons in the dorsal motor nucleus of the vagus (DMV) is altered after chronic hyperglycemia/hypoinsulinemia. Tonic gamma-aminobutyric acid A (GABA A ) inhibition prominently regulates DMV neuron activity, which contributes to autonomic control of energy homeostasis. This study investigated persistent effects of chronic hyperglycemia/hypoinsulinemia on GABA A receptor-mediated inhibition in the DMV after streptozotocin-induced type-1 diabetes using electrophysiological recordings in vitro, quantitative (q)RT-PCR, and immunohistochemistry. Application of the nonspecific GABA A receptor agonist muscimol evoked an outward current of significantly larger amplitude in DMV neurons from diabetic mice than controls. Results from application of 4,5,6,7-tetrahydroisoxazolo(5,4- c )pyridin-3-ol hydrochloride (THIP), a δ-subunit agonist, suggested that GABA A receptors containing δ-subunits contributed to the enhanced inducible tonic GABA current in diabetic mice. Sensitivity to THIP of inhibitory postsynaptic currents in DMV neurons from diabetic mice was also increased. Results from qRT-PCR and immunohistochemical analyses indicated that the altered GABAergic inhibition may be related to increased trafficking of GABA A receptors that contain the δ-subunit, rather than an expression change. Overall these findings suggest increased sensitivity of δ-subunit containing GABA A receptors after several days of hyperglycemia/hypoinsulinemia, which dramatically alters GABAergic inhibition of DMV neurons and could contribute to diabetic autonomic dysregulation. GABA tonic current diabetes Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords GABA tonic current diabetes Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Diabetes induces GABA receptor plasticity in murine vagal motor neurons Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Diabetes induces GABA receptor plasticity in murine vagal motor neurons C. R. Boychuk , K. Cs. Halmos , B. N. Smith Journal of Neurophysiology Jul 2015, 114 (1) 698-706; DOI: 10.1152/jn.00209.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Diabetes induces GABA receptor plasticity in murine vagal motor neurons C. R. Boychuk , K. Cs. Halmos , B. N. Smith Journal of Neurophysiology Jul 2015, 114 (1) 698-706; DOI: 10.1152/jn.00209.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section The rostral ventromedial medulla control of cutaneous vasomotion of paws and tail in the rat: implication for pain studies Compensatory plasticity in the olfactory epithelium: age, timing, and reversibility Mammalian target of rapamycin is required for phrenic long-term facilitation following severe but not moderate acute intermittent hypoxia Show more Control of Homeostasis Related Articles Web of Science Scopus PubMed Google Scholar Cited By... Inhibitory neurotransmission regulates vagal efferent activity and gastric motility Abstract Fulltext PDF Web of Science (2) Scopus (3) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... 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John R. Clay

doi: 10.1152/jn.00846.2014pmid: 26041831

Abstract The traditional method of recording ionic currents in neurons has been with voltage-clamp steps. Other waveforms such as action potentials (APs) can be used. The AP clamp method reveals contributions of ionic currents that underlie excitability during an AP (Bean BP. Nat Rev Neurosci 8: 451–465, 2007). A novel usage of the method is described in this report. An experimental recording of an AP from the literature is digitized and applied computationally to models of ionic currents. These results are compared with experimental AP-clamp recordings for model verification or, if need be, alterations to the model. The method is applied to the tetrodotoxin-sensitive sodium ion current, I Na , and the calcium ion current, I Ca , from suprachiasmatic nucleus (SCN) neurons (Jackson AC, Yao GL, Bean BP. J Neurosci 24: 7985–7998, 2004). The latter group reported voltage-step and AP-clamp results for both components. A model of I Na is constructed from their voltage-step results. The AP clamp computational methodology applied to that model compares favorably with experiment, other than a modest discrepancy close to the peak of the AP that has not yet been resolved. A model of I Ca was constructed from both voltage-step and AP-clamp results of this component. The model employs the Goldman-Hodgkin-Katz equation for the current-voltage relation rather than the traditional linear dependence of this aspect of the model on the Ca 2+ driving force. The long-term goal of this work is a mathematical model of the SCN AP. The method is general. It can be applied to any excitable cell. action potential clamp suprachiasmatic nucleus neurons mathematical models Goldman-Hodgkin-Katz View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords action potential clamp suprachiasmatic nucleus neurons mathematical models Goldman-Hodgkin-Katz Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Novel description of ionic currents recorded with the action potential clamp technique: application to excitatory currents in suprachiasmatic nucleus neurons Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Novel description of ionic currents recorded with the action potential clamp technique: application to excitatory currents in suprachiasmatic nucleus neurons John R. Clay Journal of Neurophysiology Jul 2015, 114 (1) 707-716; DOI: 10.1152/jn.00846.2014 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Novel description of ionic currents recorded with the action potential clamp technique: application to excitatory currents in suprachiasmatic nucleus neurons John R. Clay Journal of Neurophysiology Jul 2015, 114 (1) 707-716; DOI: 10.1152/jn.00846.2014 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section ATM protein is located on presynaptic vesicles and its deficit leads to failures in synaptic plasticity Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brain stem neurons Nitric oxide/cGMP/PKG signaling pathway activated by M 1 -type muscarinic acetylcholine receptor cascade inhibits Na + -activated K + currents in Kenyon cells Show more Cellular and Molecular Properties of Neurons Related Articles Web of Science PubMed Google Scholar Cited By... No citing articles found. Web of Science (1) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... 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Yaoguang Jiang, Dmitry Yampolsky, Gopathy Purushothaman, Vivien A. Casagrande

doi: 10.1152/jn.00068.2015pmid: 26019309

Abstract Fundamental to neuroscience is the understanding of how the language of neurons relates to behavior. In the lateral geniculate nucleus (LGN), cells show distinct properties such as selectivity for particular wavelengths, increments or decrements in contrast, or preference for fine detail versus rapid motion. No studies, however, have measured how LGN cells respond when an animal is challenged to make a perceptual decision using information within the receptive fields of those LGN cells. In this study we measured neural activity in the macaque LGN during a two-alternative, forced-choice (2AFC) contrast detection task or during a passive fixation task and found that a small proportion (13.5%) of single LGN parvocellular (P) and magnocellular (M) neurons matched the psychophysical performance of the monkey. The majority of LGN neurons measured in both tasks were not as sensitive as the monkey. The covariation between neural response and behavior (quantified as choice probability) was significantly above chance during active detection, even when there was no external stimulus. Interneuronal correlations and task-related gain modulations were negligible under the same condition. A bottom-up pooling model that used sensory neural responses to compute perceptual choices in the absence of interneuronal correlations could fully explain these results at the level of the LGN, supporting the hypothesis that the perceptual decision pool consists of multiple sensory neurons and that response fluctuations in these neurons can influence perception. thalamus vision perceptual decision choice probability Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords thalamus vision perceptual decision Choice probability Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Perceptual decision related activity in the lateral geniculate nucleus Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Perceptual decision related activity in the lateral geniculate nucleus Yaoguang Jiang , Dmitry Yampolsky , Gopathy Purushothaman , Vivien A. Casagrande Journal of Neurophysiology Jul 2015, 114 (1) 717-735; DOI: 10.1152/jn.00068.2015 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Perceptual decision related activity in the lateral geniculate nucleus Yaoguang Jiang , Dmitry Yampolsky , Gopathy Purushothaman , Vivien A. Casagrande Journal of Neurophysiology Jul 2015, 114 (1) 717-735; DOI: 10.1152/jn.00068.2015 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat Microstimulation of the lumbar DRG recruits primary afferent neurons in localized regions of lower limb Dissociating vestibular and somatosensory contributions to spatial orientation Show more Sensory Processing Related Articles Web of Science PubMed Google Scholar Cited By... Defining the V5/MT neuronal pool for perceptual decisions in a visual stereo-motion task Abstract Fulltext PDF The functional asymmetry of ON and OFF channels in the perception of contrast Abstract Fulltext PDF Web of Science (3) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Christina Z. Xia, Stacey Adjei, Daniel W. Wesson

doi: 10.1152/jn.00902.2014pmid: 26041832

Abstract Sensory systems must represent stimuli in manners dependent upon a wealth of factors, including stimulus intensity and duration. One way the brain might handle these complex functions is to assign the tasks throughout distributed nodes, each contributing to information processing. We sought to explore this important aspect of sensory network function in the mammalian olfactory system, wherein the intensity and duration of odor exposure are critical contributors to odor perception. This is a quintessential model for exploring processing schemes given the distribution of odor information by olfactory bulb mitral and tufted cells into several anatomically distinct secondary processing stages, including the piriform cortex (PCX) and olfactory tubercle (OT), whose unique contributions to odor coding are unresolved. We explored the coding of PCX and OT neuron responses to odor intensity and duration. We found that both structures similarly partake in representing descending intensities of odors by reduced recruitment and modulation of neurons. Additionally, while neurons in the OT adapt to odor exposure, they display reduced capacity to adapt to either repeated presentations of odor or a single prolonged odor presentation compared with neurons in the PCX. These results provide insights into manners whereby secondary olfactory structures may, at least in some cases, uniquely represent stimulus features. olfaction perception intensity learning adaptation Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords olfaction perception Intensity learning adaptation Article Abstract MATERIALS AND METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS ACKNOWLEDGMENTS REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Coding of odor stimulus features among secondary olfactory structures Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Coding of odor stimulus features among secondary olfactory structures Christina Z. Xia , Stacey Adjei , Daniel W. Wesson Journal of Neurophysiology Jul 2015, 114 (1) 736-745; DOI: 10.1152/jn.00902.2014 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Coding of odor stimulus features among secondary olfactory structures Christina Z. Xia , Stacey Adjei , Daniel W. Wesson Journal of Neurophysiology Jul 2015, 114 (1) 736-745; DOI: 10.1152/jn.00902.2014 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Taste coding of complex naturalistic taste stimuli and traditional taste stimuli in the parabrachial pons of the awake, freely licking rat Microstimulation of the lumbar DRG recruits primary afferent neurons in localized regions of lower limb Dissociating vestibular and somatosensory contributions to spatial orientation Show more Sensory Processing Related Articles Web of Science PubMed Google Scholar Cited By... Development of Odor Hedonics: Experience-Dependent Ontogeny of Circuits Supporting Maternal and Predator Odor Responses in Rats Abstract Fulltext PDF Web of Science (1) Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Bryan D. He, Alex Wein, Lav R. Varshney, Julius Kusuma, Andrew G. Richardson, Lakshminarayan Srinivasan

doi: 10.1152/jn.00623.2014pmid: 25904712

Abstract Efficient spike acquisition techniques are needed to bridge the divide from creating large multielectrode arrays (MEA) to achieving whole-cortex electrophysiology. In this paper, we introduce generalized analog thresholding (gAT), which achieves millisecond temporal resolution with sampling rates as low as 10 Hz. Consider the torrent of data from a single 1,000-channel MEA, which would generate more than 3 GB/min using standard 30-kHz Nyquist sampling. Recent neural signal processing methods based on compressive sensing still require Nyquist sampling as a first step and use iterative methods to reconstruct spikes. Analog thresholding (AT) remains the best existing alternative, where spike waveforms are passed through an analog comparator and sampled at 1 kHz, with instant spike reconstruction. By generalizing AT, the new method reduces sampling rates another order of magnitude, detects more than one spike per interval, and reconstructs spike width. Unlike compressive sensing, the new method reveals a simple closed-form solution to achieve instant (noniterative) spike reconstruction. The base method is already robust to hardware nonidealities, including realistic quantization error and integration noise. Because it achieves these considerable specifications using hardware-friendly components like integrators and comparators, generalized AT could translate large-scale MEAs into implantable devices for scientific investigation and medical technology. spike acquisition multielectrode arrays sub-Nyquist finite rate of innovation brain initiative Copyright © 2015 the American Physiological Society View Full Text Previous Next Back to top View this article with LENS What is LENS? About the Cover About the Cover This is a PDF-only article. The first page of the PDF of this article appears below. Table of Contents Back Matter (PDF) Ed Board (PDF) Keywords spike acquisition multielectrode arrays sub-Nyquist finite rate of innovation BRAIN initiative Article Abstract METHODS RESULTS DISCUSSION GRANTS DISCLOSURES AUTHOR CONTRIBUTIONS Appendix REFERENCES Figures & Data Info E-letters PDF Alert me when this article is cited Alert me if a correction is posted Email Thank you for your interest in spreading the word on Journal of Neurophysiology. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Generalized analog thresholding for spike acquisition at ultralow sampling rates Message Subject (Your Name) has sent you a message from Journal of Neurophysiology Message Body (Your Name) thought you would like to see the Journal of Neurophysiology web site. Your Personal Message Print Citation Tools Generalized analog thresholding for spike acquisition at ultralow sampling rates Bryan D. He , Alex Wein , Lav R. Varshney , Julius Kusuma , Andrew G. Richardson , Lakshminarayan Srinivasan Journal of Neurophysiology Jul 2015, 114 (1) 746-760; DOI: 10.1152/jn.00623.2014 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Request Permissions Share Generalized analog thresholding for spike acquisition at ultralow sampling rates Bryan D. He , Alex Wein , Lav R. Varshney , Julius Kusuma , Andrew G. Richardson , Lakshminarayan Srinivasan Journal of Neurophysiology Jul 2015, 114 (1) 746-760; DOI: 10.1152/jn.00623.2014 Permalink: Copy View Full Page PDF Tweet Widget Facebook Like Google Plus One Reddit CiteULike Mendeley StumbleUpon More in this TOC Section Air-Track: A real-world floating environment for active sensing in head-fixed mice Integration of autopatching with automated pipette and cell detection in vitro Optogenetic manipulation of neural circuits in awake marmosets. Show more Innovative Methodology Related Articles Web of Science PubMed Google Scholar Cited By... No citing articles found. Google Scholar Most Read Most Cited Theories of pain: from specificity to gate control Reward, Motivation, and Emotion Systems Associated With Early-Stage Intense Romantic Love Predictive Reward Signal of Dopamine Neurons Reward, Addiction, and Emotion Regulation Systems Associated With Rejection in Love The organization of the human cerebral cortex estimated by intrinsic functional connectivity More... GA_googleFillSlot("JN_tower_right_160x600"); Navigate Current Issue Articles in Press Archives Feedback Submit Subscribe Personal Alerts More Information About this Journal Information for Authors Submit a Manuscript Press Advertising AuthorChoice Calls for Papers Ethics Policy PubMed Central Policy Reprints and Permissions Institutional Administrators APS Publications News Follow APS Publications on Twitter American Physiological Society Journals Cell Physiology Advances in Physiology Education Comprehensive Physiology Endocrinology and Metabolism Gastrointestinal and Liver Physiology Heart and Circulatory Physiology Journal of Applied Physiology Journal of Neurophysiology Lung Cellular and Molecular Physiology Physiological Genomics Physiological Reviews Physiology Regulatory, Integrative and Comparative Physiology Renal Physiology Physiological Reports Legacy Content APS Select www.physiology.org Copyright © 2016 The American Physiological Society | Print ISSN: 0022-3077 | Online ISSN: 1522-1598

Aasef G. Shaikh

doi: 10.1152/jn.00430.2015pmid: 26220606

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