American Journal of Psychiatry

Myron G. Sandifer, Jr.

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OLTMAN, JANE E.; FRIEDMAN, SAMUEL

doi: 10.1176/appi.ajp.116.9.848pmid: 14428837

JANE E. OLTMAN M.D. 1 , and SAMUEL FRIEDMAN M.D. 2 1 Clinical Director, Fairfield State Hospital, Newtown, Conn. 2 Assistant Superintendent, Fairfield State Hospital, Newtown, Conn. Marplan is a safe, effective drug in the treatment of depressive states. Good to excellent results were obtained in 70% of a series of 100 hospitalized patients suffering from depressive illnesses. Complications or side effects are minor.

CAHAN, ROBERT B.

doi: 10.1176/appi.ajp.116.9.838pmid: 13806782

ROBERT B. CAHAN M.D. 1 1 Norristown State Hospital, Norristown, Pa. Trifluoperazine is considered to be of limited usefulness and considerable toxicity in an elderly female population. The 8 patients with increased muscular rigidity having 4 of their number improved by Stelazine should be contrasted with the absence of psychiatric improvement among the 8 women with muscular weakness. Investigation of this phenomenon may reveal clues to the operation of trifluoperazine. On the positive side, no agranulocytic, hepatotoxic, or biliary static effects were noted. A therapeutic agent which can improve the ward management of one-fifth of the severely and chronically ill patients should be considered as part of the psychotherapeutic armamentarium.

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HIRAM K. JOHNSON

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IRENE S. FORREST and FRED M. FORREST

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C. E. SCHORER

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ANTHONY J. GRAFFEO

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WILFRED BLOOMBERG

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E. DOUGLASS

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