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This article reviews parameters of extrinsic uncoupling of oxidative phosphorylation (OxPhos) in mitochondria, based on induction of a proton leak across the inner membrane. The effects of classical ...
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Oxidative stress is implicated as an important molecular mechanism underlying fibrosis in a variety of organs, including the lungs. However, the causal role of reactive oxygen species (ROS) released ...
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the biosynthesis of ATP and the production of ROS. UCP2 activity leads to dissipation of the electrochemical potential difference and results in uncoupling of oxidation and phosphorylation, thus reduction of ATP ...
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a overdosing, which even resulted in several fatalities. Later on, it was demonstrated that DNP acted as an uncoupler of oxidative phosphorylation, while facilitating proton transport across the inner ...
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utilization under basal and oligomycin-inhibited conditions. This resulted in a decrease in cellular ATP levels consistent with compromised cellular function. This uncoupling of mitochondrial oxidative ...
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, thrombosis, vascular inflammation, and proliferation of vascular smooth muscle cells. Vascular oxidative stress with an increased production of reactive oxygen species (ROS) contributes to mechanisms ...
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and Singer, 1993 ). MPTP induces neurotoxicity in animal brains by a mechanism of mitochondria-oxidative stress-energy failure ( Fabre et al., 1999 ). Mice exposed to MPTP show reduction in levels ...
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. ► Current understanding of mechanism of electron transfer and interdomain interaction in NOS regulation is discussed. 1 Introduction 1.1 Biomedical significance of nitric oxide synthase (NOS ...
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Key mechanisms relating oxidative stress to longevity from an interespecies comparative approach are reviewed. Long-lived animal species show low rates of reactive oxygen species (ROS) generation ...