Did you mean: transcription factor families muscle in on the myogenic program
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Skeletal muscle differentiation is regulated by transcription factors, including members of the myogenic regulatory factor (MRF) family and many signaling pathways. The JAK1 and JAK2 pathways ...
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transcription factor families are critical for the myogenic program. The differentiation of C2C12 myoblasts in vitro mimics many of the gene expression patterns seen in the embryo and thus represents an excellent ...
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Highlights ► CDA-II inhibits myogenic differentiation in a dose-dependent manner. ► CDA-II repressed expression of muscle transcription factors and structural proteins. ► CDA-II inhibited ...
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; L'Honore et al., 2007; Qiu et al., 2008; Shih et al., 2007a ). Indeed, Pitx2 can positively regulate Myf5 and MyoD expression, members of the myogenic regulatory factor (MRF) family of transcription factors ...
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of the IL-6 family, namely leukemia inhibitory factor (LIF; Refs. 2 , 11) and cardiotrophin-1 (CT-1; Ref. 17 ), have been reported to inhibit myogenic differentiation in skeletal muscle cells. The signal ...
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of genes coding myogenic regulatory factors and other related factors. Such myogenic regulatory factors (MRFs) are a family of muscle basic helix–loop–helix (bHLH) transcription factors comprised of Myf5 ...
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. © 2009 Wiley‐Liss, Inc. Skeletal muscle specification and differentiation are controlled by a family of transcription factors known as myogenic regulatory factors (MRFs) [Pownall et al., 2002 ; Blais et ...
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differentiation program. Therefore, these transcription factors were postulated to have a master regulatory role in the development of the skeletal muscle lineage (Weintraub et al. 1991). The MRFs family have been ...
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> Cellular differentiation is controlled by the activation or repression of specific target genes. The basic domain helix–loop–helix (bHLH) * family of transcription factors has been shown to regulate several ...