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This article discusses the current understanding of the role of free radicals and antioxidants in inflammatory processes and in ischemia reperfusion injury. It begins by describing the manifestations ...
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Abstract Neutrophils are pivotal in the pathogenesis of ischemia-reperfusion (I/R) injury leading to muscle damage. Firm adhesion of neutrophils to the endothelium is initiated by an interaction ...
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can bind to the venular wall at low shear rates. P-selectin neutrophils CD18 ischemia blood flow and the accompanying shear forces generated by blood moving within venules can exert a significant ...
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to healthy tissues can lead to unwanted disorders and pathologic conditions, including but not limited to ischemia-reperfusion injury, acute respiratory distress syndrome, and some types of arthritis ...
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forces (including hydrostatic pressure, cyclic stretch, and fluid shear stress) induced by the pulsatile blood pressure and flow ( Fig. 3 ). As a monolayer in direct contact with the flowing blood, ECs ...
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ischemia and 60 min reperfusion in the feline mesentery. Preconditioning (5 min ischemia/10 min reperfusion) prevented subsequent I/R-induced slow neutrophil rolling, neutrophil adhesion, and microvascular ...
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play a crucial role in the damage caused by ischemia–reperfusion in various organs ( Hisama et al., 1996; Daemen et al., 2000; Pockley et al., 2000 ). In canine skeletal muscle, Korthuis et al. (1988 ...
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This review focuses on the role of oxidative processes in atherosclerosis and its resultant cardiovascular events. There is now a consensus that atherosclerosis represents a state of heightened ...
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synthesis of PAF. Doubts remain regarding the relative importance of integrins and selectins in of s to endothelium ischemia and reperfusion, the role of different activating mediators, and the response ...