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and systemic types, with the latter further stratified by the presence or absence of anaplastic lymphoma kinase (ALK) protein expression. Systemic ALCL is an aggressive subtype of mature NK-T cell lymphomas ...
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The normal functions of full‐length anaplastic lymphoma kinase (ALK) remain to be completely elucidated. Although considered to be important in neural development, recent studies in Drosophila also ...
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. Background In pediatric neuroblastoma (NBL), high anaplastic lymphoma kinase (ALK) levels appear to be correlated with an unfavorable prognosis, regardless of ALK mutation status. This suggests a therapeutic ...
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further supports the concept that SALL4 is biologically important in ALK + ALCL. Lastly, the expression of SALL4 was not dependent on the nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK)/STAT3 signaling ...
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Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase (RTK) involved in the genesis of several human cancers; indeed, ALK was initially identified in constitutively activated and oncogenic ...
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] . The consequence of this cytogenetic abnormality is the formation of an abnormal fusion protein, namely nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK) [17–21] . Extensive previous studies have shown that NPM ...
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Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase essentially and transiently expressed during development in specific regions of the central and peripheral nervous system. ALK ...
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The nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) fusion oncoprotein, formed by the t (2;5) chromosomal translocation in anaplastic large-cell lymphomas, has constitutive tyrosine kinase ...
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, we investigated the sensitivity of HGF- and MET-dependent AML cell lines to chemical inhibition of the MET kinase using the specific MET and anaplastic lymphoma receptor tyrosine kinase (ALK) inhibitor ...