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of the mononuclear phagocyte lineage fuse to form multinucleated giant cells and osteoclasts. Several lines of evidence suggest that P2 receptors, in particular P2X7, are involved in this process, although P2X7 ...
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will discuss the complex role of extracellular nucleotides in the regulation of DC function and the role of P2 receptors as possible tools to manipulate immune responses. Dendritic cells (DCs) activate ...
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express members of the P2 receptor superfamily. Human monocyte-derived dendritic cells are reported to express mRNA for P2Y1, P2Y2, P2Y4, P2Y5, P2Y6, P2Y10, P2Y11, and P2Y13 from the P2Y receptor side ...
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subtypes of P2 receptors in two lines of human intestinal epithelial cells. We have shown that the stimulation or dysfunction of the P2X1-7 receptors P2Y 1 and P2Y 2 may contribute, at least in part ...
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Activation of the P2X7 receptor (P2X7R) triggers a remarkably diverse array of membrane trafficking responses in leukocytes and epithelial cells. These responses result in altered profiles of cell ...
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by purinergic signalling in mononuclear cell differentiation and function. Among P2 receptors, P2X7 is a hot focus of investigation for its undisputed role in inflammasome activation and cytokine release ...
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(P2Y2, P2Y4, P2Y6, P2X subtypes and A1 receptors) and in glucagon-secreting cells (P2X7, A2 receptors). In the exocrine pancreas, acini release ATP and ATP-hydrolysing and ATP-generating enzymes. P2 ...
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only under severe pathophysiological conditions. There is now accruing evidence that in the absence of stimulation by exogenously-added ATP the P2X7 receptor may sustain cell growth, and may thus ...
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in uncovering some of the molecular mechanisms underlying dendrite development. I will also discuss the potential relevance of our studies to human neurological disorders. KS-003 Title: Understanding receptor ...