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Activation of signal transducers and activators of transcription 3 in the hippocampal CA1 region in a rat model of global cerebral ischemic preconditioning
Yagi, Takashi; Yoshioka, Hideyuki; Wakai, Takuma; Kato, Tatsuya; Horikoshi, Toru; Kinouchi, Hiroyuki
Follow Brain Research , Volume 1422
Elsevier – Nov 8, 2011The signal transducers and activators of transcription 3 (STAT3) has been suggested to have neuroprotective roles. However, its role in ischemic preconditioning (PC) is still obscure. In this study ...
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Cosmomycin C inhibits signal transducer and activator of transcription 3 (STAT3) pathways in MDA-MB-468 breast cancer cell
Kim, Jihoon; Lee, Yu-Jin; Shin, Dae-Seop; Jeon, Sun-Hee; Son, Kwang-Hee; Han, Dong Cho; Jung, Seung-Nam; Oh, Tae-Kwang; Kwon, Byoung-Mog
Follow Bioorganic & Medicinal Chemistry , Volume 19 (24)
Elsevier – Dec 15, 2011. 1 Introduction Signal transducer and activator of transcription proteins (STATs) are a family of latent cytoplasmic transcription factors that are activated by extracellular stimuli ...
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Mitochondrial DNA copy number is modulated by genetic variation in the signal transducer and activator of transcription 3 ( STAT3 )
Gianotti, Tomas Fernández; Castaño, Gustavo; Gemma, Carolina; Burgueño, Adriana L.; Rosselli, Maria Soledad; Pirola, Carlos J.; Sookoian, Silvia
Follow Metabolism , Volume 60 (8)
Elsevier – Aug 1, 2011that the signal transducer and activator of transcription 3 ( STAT3 ) is involved in the regulation of the mitochondrial function and is required for the optimal function of the electron transport chain ...
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Signal transducer and activator of transcription 3 pathway mediates genipin‐induced apoptosis in U266 multiple myeloma cells
Lee, Jang Choon; Ahn, Kwang Seok; Jeong, Soo‐Jin; Jung, Ji Hoon; Kwon, Tae‐Rin; Rhee, Yun‐Hee; Kim, Sun‐Hee; Kim, Si‐Young; Yoon, Hwi‐Joong; Zhu, Shudong; Chen, Chang‐Yan; Kim, Sung‐Hoon
Follow Journal of Cellular Biochemistry , Volume 112 (6)
Wiley – Apr 18, 2011It has drawn a lot of attention to target signal transducer and activator of transcription 3 (STAT3) as a potential strategy for cancer therapeutics. Using several myelogenous cell lines, the effect ...
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Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer
Proietti, Cecilia J.; Béguelin, Wendy; Flaqué María Celeste Díaz; Cayrol, Florencia; Rivas, Martín A.; Tkach, Mercedes; Charreau, Eduardo H.; Schillaci, Roxana; Elizalde, Patricia V.
Follow Steroids , Volume 76 (4)
Elsevier – Mar 1, 2011of action of PR. 1 Introduction Progesterone receptor (PR) and the signal transducer and activator of transcription 3 (Stat3) are major players in the breast cancer scenario. In its classical ...
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Cardioprotection by ischemic postconditioning is abolished in depressed rats: role of Akt and signal transducer and activator of transcription-3
Chuanjun, Zhuo; Ying, Wang; Xiaohui, Wang; Yufen, Wang; Yuhui, Chen
Follow Molecular and Cellular Biochemistry , Volume 346 (1)
Springer Journals – Jan 1, 2011and phosphorylated AKT and signal transducer and activator of transcription-3 (STAT-3) were measured. IPC signiï¬cantly prevented the hearts from myocardial ischemia/reperfusion injury by decreasing infarct size ...
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Activation of Janus kinase/signal transducer and activator of transcription 3 pathway by growth hormone-releasing hormone
Agnieszka, Siejka; Andrew, Schally; Nektarios, Barabutis
Follow Cellular and Molecular Life Sciences , Volume 67 (6)
Springer Journals – Mar 1, 2010therapies, one of us (A.V.S.) developed GHRH antagonists which have a strong antiproliferative activity in various experimental cancer models [3]. The inhibitory effect of these analogues is exerted in part ...
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A novel mutation in the signal transducer and activator of transcription 3 (STAT3) gene, in hyper-IgE syndrome
Papanastasiou, Anastasios D.; Mantagos, Stefanos; Papanastasiou, Dimitrios A.; Zarkadis, Ioannis K.
Follow Molecular Immunology , Volume 47 (7)
Elsevier – Apr 1, 2010, it was shown that heterozygous mutations in signal transducer and activator of transcription 3 (STAT3), can cause autosomal-dominant HIES. Here we identify and characterize a novel mutation in the DNA-binding ...
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Signal transducer and activator of transcription 3 is a transcriptional factor regulating the gene expression of SALL4
Bard, J. Dien; Gelebart, P.; Amin, H. M.; Young, L. C.; Ma, Y.; Lai, R.
Follow The FASEB Journal , Volume 23 (5): 1405
Fed of American Socs for Experimental Biology – May 1, 2009Both signal transducer and activator of transcription 3 (STAT3) and SALL4 are important in maintaining the pluripotent and self-renewal state of embryonic stem cells. We hypothesized that STAT3 ...
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Honokiol inhibits signal transducer and activator of transcription‐3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP‐1
Rajendran, Peramaiyan; Li, Feng; Shanmugam, Muthu K.; Vali, Shireen; Abbasi, Taher; Kapoor, Shweta; Ahn, Kwang Seok; Kumar, Alan Prem; Sethi, Gautam
Follow Journal of Cellular Physiology , Volume 227 (5)
Wiley – Jan 23, 2012The activation of signal transducers and activators of transcription 3 (STAT3) has been closely linked with the proliferation, survival, invasion, and angiogenesis of hepatocellular carcinoma (HCC ...
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